{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:50:17Z","timestamp":1790769017997,"version":"4.1.0"},"reference-count":5,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T00:00:00Z","timestamp":1432080000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this Viewpoint, we summarize and discuss the recent serendipitous discovery of an astrocyte Kir4.1 potassium channel dysfunction in two mouse models of Huntington\u2019s disease (HD). Restoration of Kir4.1 channels within astrocytes in vivo attenuated neuronal dysfunction, some aspects of motor dysfunction and increased survival time in a HD mouse model. Overall, the data show that aspects of altered neuronal excitability associated with HD may be secondary to changes in astrocyte-mediated K+ homeostasis, thereby revealing a new striatal neural microcircuit mechanism in HD, and Kir4.1 channels and astrocytes as potential therapeutic targets for drug development.<\/jats:p>","DOI":"10.1021\/cn500100r","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T06:58:20Z","timestamp":1400569100000},"page":"494-496","source":"Crossref","is-referenced-by-count":33,"title":["Astrocytes and Huntington\u2019s Disease"],"prefix":"10.1021","volume":"5","author":[{"given":"Baljit S.","family":"Khakh","sequence":"first","affiliation":[{"name":"University of California, Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095-1751"]},{"name":"University of California, Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095-1751"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Sofroniew","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095-1751"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,5,20]]},"reference":[{"key":"2026090203273912000_cit1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nrd4164","article-title":"Does size matter in\nR&D productivity? If not, what does?","volume":"12","author":"Ringel","year":"2013","journal-title":"Nat.\nRev. Drug Discovery"},{"key":"2026090203273912000_cit2","doi-asserted-by":"crossref","first-page":"22480","DOI":"10.1073\/pnas.0911503106","article-title":"Expression of mutant huntingtin in mouse brain astrocytes causes\nage-dependent neurological symptoms","volume":"106","author":"Bradford","year":"2009","journal-title":"Proc. Natl.\nAcad. Sci. U.S.A."},{"key":"2026090203273912000_cit3","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nn.3691","article-title":"Astrocyte Kir4.1 ion channel deficits contribute to\nneuronal dysfunction in Huntington\u2019s disease model mice","volume":"17","author":"Tong","year":"2014","journal-title":"Nat. Neurosci."},{"key":"2026090203273912000_cit4","doi-asserted-by":"crossref","first-page":"14489","DOI":"10.1523\/JNEUROSCI.1256-12.2012","article-title":"Inflammatory mediators alter the\nastrocyte transcriptome and calcium signaling elicited by multiple\nG-protein-coupled receptors","volume":"32","author":"Hamby","year":"2012","journal-title":"J. Neurosci."},{"key":"2026090203273912000_cit5","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","article-title":"A transcriptome\ndatabase for astrocytes, neurons, and oligodendrocytes: a new resource\nfor understanding brain development and function","volume":"28","author":"Cahoy","year":"2008","journal-title":"J. Neurosci."}],"container-title":["ACS Chemical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cn500100r","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acncdm\/article-pdf\/5\/7\/494\/8640299\/cn500100r.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acncdm\/article-pdf\/5\/7\/494\/8640299\/cn500100r.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:27:42Z","timestamp":1788334062000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acncdm\/article\/5\/7\/494\/831983\/Astrocytes-and-Huntington-s-Disease"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,20]]},"references-count":5,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,5,20]]},"published-print":{"date-parts":[[2014,7,16]]}},"URL":"https:\/\/doi.org\/10.1021\/cn500100r","relation":{},"ISSN":["1948-7193"],"issn-type":[{"value":"1948-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,20]]}}}