{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:14:00Z","timestamp":1788513240331,"version":"build-2803163510"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:00:00Z","timestamp":1444780800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000145","name":"Alberta Innovates - Health Solutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P30-NS055022"],"award-info":[{"award-number":["P30-NS055022"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Low-voltage-activated (T-type) calcium channels are important regulators of the transmission of nociceptive information in the primary afferent pathway and finding ligands that modulate these channels is a key focus of the drug discovery field. Recently, we characterized a set of novel compounds with mixed cannabinoid receptor\/T-type channel blocking activity and examined their analgesic effects in animal models of pain. Here, we have built on these previous findings and synthesized a new series of small organic compounds. We then screened them using whole-cell voltage clamp techniques to identify the most potent T-type calcium channel inhibitors. The two most potent blockers (compounds 9 and 10) were then characterized using radioligand binding assays to determine their affinity for CB1 and CB2 receptors. The structure\u2013activity relationship and optimization studies have led to the discovery of a new T-type calcium channel blocker, compound 9. Compound 9 was efficacious in mediating analgesia in mouse models of acute inflammatory pain and in reducing tactile allodynia in the partial nerve ligation model. This compound was shown to be ineffective in Cav3.2 T-type calcium channel null mice at therapeutically relevant concentrations, and it caused no significant motor deficits in open field tests. Taken together, our data reveal a novel class of compounds whose physiological and therapeutic actions are mediated through block of Cav3.2 calcium channels.<\/jats:p>","DOI":"10.1021\/cn500206a","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T08:36:28Z","timestamp":1413275788000},"page":"277-287","source":"Crossref","is-referenced-by-count":45,"title":["Characterization of Novel Cannabinoid Based T-Type Calcium Channel Blockers\nwith Analgesic Effects"],"prefix":"10.1021","volume":"6","author":[{"given":"Chris","family":"Bladen","sequence":"first","affiliation":[{"name":"University of Calgary , , , ,","place":["Calgary, AB, Canada, T2N 1N4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"McDaniel","sequence":"additional","affiliation":[{"name":"The University of Montana , , , ,","place":["Missoula, Montana, United States, 59812"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius M.","family":"Gadotti","sequence":"additional","affiliation":[{"name":"University of Calgary , , , ,","place":["Calgary, AB, Canada, T2N 1N4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravil R.","family":"Petrov","sequence":"additional","affiliation":[{"name":"The University of Montana , , , ,","place":["Missoula, Montana, United States, 59812"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Daniel","family":"Berger","sequence":"additional","affiliation":[{"name":"University of Calgary , , , ,","place":["Calgary, AB, Canada, T2N 1N4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Diaz","sequence":"additional","affiliation":[{"name":"The University of Montana , , , ,","place":["Missoula, Montana, United States, 59812"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald W.","family":"Zamponi","sequence":"additional","affiliation":[{"name":"University of Calgary , , , ,","place":["Calgary, AB, Canada, T2N 1N4"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,10,14]]},"reference":[{"key":"2026090402071020200_cit1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.tins.2007.06.010","article-title":"Dendritic mechanisms controlling\nspike-timing-dependent synaptic plasticity","volume":"30","author":"Kampa","year":"2007","journal-title":"Trends Neurosci."},{"key":"2026090402071020200_cit2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4161\/chan.4.5.12874","article-title":"Splice-variant changes of the Ca(V)3.2 T-type calcium\nchannel mediate voltage-dependent facilitation and associate with\ncardiac hypertrophy and development","volume":"4","author":"David","year":"2010","journal-title":"Channels"},{"key":"2026090402071020200_cit3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yjmcc.2009.08.021","article-title":"Cardiac T-type Ca2+ channels in the heart","volume":"48","author":"Ono","year":"2010","journal-title":"J. Mol. Cell\nCardiol."},{"key":"2026090402071020200_cit4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ceca.2006.04.025","article-title":"Role of\nT-type Ca2+ channels\nin the heart","volume":"40","author":"Vassort","year":"2006","journal-title":"Cell calcium"},{"key":"2026090402071020200_cit5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1113\/jphysiol.2011.218768","article-title":"Control\nof firing\npatterns through modulation of axon initial segment T-type calcium\nchannels","volume":"590","author":"Bender","year":"2012","journal-title":"J. Physiol."},{"key":"2026090402071020200_cit6","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1523\/JNEUROSCI.4866-06.2007","article-title":"Cell-specific alterations of T-type calcium current\nin painful diabetic neuropathy enhance excitability of sensory neurons","volume":"27","author":"Jagodic","year":"2007","journal-title":"J. Neurosci."},{"key":"2026090402071020200_cit7","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/ana.21169","article-title":"Extended spectrum of idiopathic generalized epilepsies\nassociated with CACNA1H functional variants","volume":"62","author":"Heron","year":"2007","journal-title":"Ann. Neurol."},{"key":"2026090402071020200_cit8","doi-asserted-by":"crossref","first-page":"9681","DOI":"10.1074\/jbc.C400006200","article-title":"Gating Effects\nof Mutations in the Cav3.2 T-type Calcium Channel Associated with\nChildhood Absence Epilepsy","volume":"279","author":"Khosravani","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2026090402071020200_cit9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ana.20458","article-title":"Effects of Cav3.2\nchannel mutations linked to idiopathic\ngeneralized epilepsy","volume":"57","author":"Khosravani","year":"2005","journal-title":"Ann. Neurol."},{"key":"2026090402071020200_cit10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1523\/JNEUROSCI.5295-08.2009","article-title":"A Cav3.2\nT-type calcium channel point mutation has splice-variant-specific\neffects on function and segregates with seizure expression in a polygenic\nrat model of absence epilepsy","volume":"29","author":"Powell","year":"2009","journal-title":"J. Neurosci."},{"key":"2026090402071020200_cit11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00424-009-0772-x","article-title":"Role of voltage-gated\ncalcium channels\nin epilepsy","volume":"460","author":"Zamponi","year":"2010","journal-title":"Pflu\u0308gers Arch."},{"key":"2026090402071020200_cit12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejphar.2005.08.017","article-title":"The antihyperalgesic\neffects of the\nT-type calcium channel blockers ethosuximide, trimethadione, and mibefradil","volume":"521","author":"Barton","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"2026090402071020200_cit13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.emboj.7600515","article-title":"Silencing of the Cav3.2 T-type calcium\nchannel gene in sensory neurons demonstrates its major role in nociception","volume":"24","author":"Bourinet","year":"2005","journal-title":"EMBO J."},{"key":"2026090402071020200_cit14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1601-183X.2006.00268.x","article-title":"Attenuated\npain responses in mice lacking Ca(V)3.2 T-type channels","volume":"6","author":"Choi","year":"2007","journal-title":"Genes, Brain Behav."},{"key":"2026090402071020200_cit15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3959(03)00177-5","article-title":"Reversal of experimental neuropathic pain by T-type\ncalcium channel blockers","volume":"105","author":"Dogrul","year":"2003","journal-title":"Pain"},{"key":"2026090402071020200_cit16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1744-8069-9-32","article-title":"Analgesic\neffect of a mixed T-type channel inhibitor\/CB2 receptor agonist","volume":"9","author":"Gadotti","year":"2013","journal-title":"Mol. Pain"},{"key":"2026090402071020200_cit17","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1152\/jn.01031.2007","article-title":"Upregulation\nof the T-type calcium current in small\nrat sensory neurons after chronic constrictive injury of the sciatic\nnerve","volume":"99","author":"Jagodic","year":"2008","journal-title":"J. Neurophysiol."},{"key":"2026090402071020200_cit18","doi-asserted-by":"crossref","first-page":"e91467","DOI":"10.1371\/journal.pone.0091467","article-title":"CaV3.2 T-Type Calcium Channels in\nPeripheral Sensory\nNeurons Are Important for Mibefradil-Induced Reversal of Hyperalgesia\nand Allodynia in Rats with Painful Diabetic Neuropathy","volume":"9","author":"Obradovic","year":"2014","journal-title":"PloS One"},{"key":"2026090402071020200_cit19","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/ddr.20103","article-title":"T-type calcium channels:\nan emerging therapeutic target\nfor the treatment of pain","volume":"67","author":"Snutch","year":"2006","journal-title":"Drug Dev. Res."},{"key":"2026090402071020200_cit20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00424-014-1452-z","article-title":"Targeting\nof CaV3.2 T-type calcium channels in peripheral\nsensory neurons for the treatment of painful diabetic neuropathy","volume":"466","author":"Todorovic","year":"2014","journal-title":"Pflu\u0308gers Arch."},{"key":"2026090402071020200_cit21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainresrev.2008.12.021","article-title":"Role of\nvoltage-gated calcium channels in ascending pain pathways","volume":"60","author":"Zamponi","year":"2009","journal-title":"Brain Res. Rev."},{"key":"2026090402071020200_cit22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physrev.00018.2002","article-title":"Molecular\nphysiology of low-voltage-activated t-type calcium channels","volume":"83","author":"Perez-Reyes","year":"2003","journal-title":"Physiol. Rev."},{"key":"2026090402071020200_cit23","doi-asserted-by":"crossref","first-page":"13106","DOI":"10.1523\/JNEUROSCI.2919-09.2009","article-title":"T-type calcium channel inhibition\nunderlies the analgesic effects of the endogenous lipoamino acids","volume":"29","author":"Barbara","year":"2009","journal-title":"J. Neurosci."},{"key":"2026090402071020200_cit24","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s00424-013-1376-z","article-title":"Synthesis\nand Evaluation of 1,4-Dihydropyridine Derivatives with Calcium Channel\nBlocking Activity","volume":"466","author":"Bladen","year":"2013","journal-title":"Pflu\u0308gers Arch."},{"key":"2026090402071020200_cit25","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1093\/emboj\/20.24.7033","article-title":"Direct inhibition\nof T-type calcium channels by the endogenous cannabinoid anandamide","volume":"20","author":"Chemin","year":"2001","journal-title":"EMBO J."},{"key":"2026090402071020200_cit26","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ardp.200800079","article-title":"Synthesis and SAR study of T-type\ncalcium channel blockers. Part II","volume":"341","author":"Choe","year":"2008","journal-title":"Arch. Pharm."},{"key":"2026090402071020200_cit27","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/sj.bjp.0705944","article-title":"Identification of R(\u2212)-isomer\nof efonidipine as a selective blocker of T-type Ca2+ channels","volume":"143","author":"Furukawa","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"2026090402071020200_cit28","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.pain.2010.12.035","article-title":"A novel slow-inactivation-specific ion channel modulator\nattenuates neuropathic pain","volume":"152","author":"Hildebrand","year":"2011","journal-title":"Pain"},{"key":"2026090402071020200_cit29","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bmc.2006.09.051","article-title":"Novel T-type calcium\nchannel blockers: dioxoquinazoline\ncarboxamide derivatives","volume":"15","author":"Jo","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"2026090402071020200_cit30","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0026-895X(24)12129-3","article-title":"Synthesis and evaluation\nof a new class of nifedipine\nanalogs with T-type calcium channel blocking activity","volume":"61","author":"Kumar","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"2026090402071020200_cit31","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/jpet.108.145672","article-title":"Molecular pharmacology of human Cav3.2\nT-type Ca2+ channels: block by antihypertensives, antiarrhythmics,\nand their analogs","volume":"328","author":"Perez-Reyes","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090402071020200_cit32","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1097\/HJH.0b013e3283388045","article-title":"Benidipine,\na dihydropyridine L-type\/T-type calcium channel blocker, affords additive\nbenefits for prevention of cardiorenal injury in hypertensive rats","volume":"28","author":"Yamamoto","year":"2010","journal-title":"J. Hypertens."},{"key":"2026090402071020200_cit33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1124\/mol.109.059022","article-title":"CCR2 receptor ligands inhibit Cav3.2\nT-type calcium channels","volume":"77","author":"You","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"2026090402071020200_cit34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1744-8069-7-89","article-title":"Functional\ncharacterization and analgesic effects of mixed cannabinoid receptor\/T-type\nchannel ligands","volume":"7","author":"You","year":"2011","journal-title":"Mol. Pain"},{"key":"2026090402071020200_cit35","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1074\/jbc.M610033200","article-title":"Chemical determinants involved in\nanandamide-induced inhibition of T-type calcium channels","volume":"282","author":"Chemin","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2026090402071020200_cit36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.beem.2008.09.003","article-title":"Central side-effects of therapies\nbased on CB1 cannabinoid receptor agonists and antagonists: focus\non anxiety and depression","volume":"23","author":"Moreira","year":"2009","journal-title":"Best. Pract. Res.,\nClin. Endocrinol. Metab."},{"key":"2026090402071020200_cit37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00008877-200509000-00005","article-title":"A role for cannabinoid CB1 receptors\nin mood and anxiety disorders","volume":"16","author":"Witkin","year":"2005","journal-title":"Behav. Pharmacol."},{"key":"2026090402071020200_cit38","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.ejmech.2013.09.038","article-title":"Mastering tricyclic\nring systems for desirable functional cannabinoid activity","volume":"69","author":"Petrov","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"2026090402071020200_cit39","first-page":"F674","article-title":"A role for T-type\nCa2+ channels in the synergistic control of aldosterone\nproduction by ANG II and K+","volume":"276","author":"Chen","year":"1999","journal-title":"Am. J. Physiol."},{"key":"2026090402071020200_cit40","doi-asserted-by":"crossref","first-page":"11268","DOI":"10.1073\/pnas.1100869108","article-title":"T-type calcium\nchannels contribute to colonic hypersensitivity in a rat model of\nirritable bowel syndrome","volume":"108","author":"Marger","year":"2011","journal-title":"Proc. Natl. Acad.\nSci. U. S. A."},{"key":"2026090402071020200_cit41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1471-4159.2012.07667.x","article-title":"The T-type voltage-gated calcium channel as a molecular\ntarget of the novel cognitive enhancer ST101: Enhancement of long-term\npotentiation and CaMKII autophosphorylation in rat cortical slices","volume":"121","author":"Moriguchi","year":"2012","journal-title":"J. Neurochem."},{"key":"2026090402071020200_cit42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ceca.2006.04.024","article-title":"The role of peripheral T-type calcium channels in pain\ntransmission","volume":"40","author":"Jevtovic-Todorovic","year":"2006","journal-title":"Cell Calcium"},{"key":"2026090402071020200_cit43","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.2337\/db13-0813","article-title":"Reversal of neuropathic pain in diabetes\nby targeting glycosylation of Ca(V)3.2 T-type calcium channels","volume":"62","author":"Orestes","year":"2013","journal-title":"Diabetes"},{"key":"2026090402071020200_cit44","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1476-5381.2011.01256.x","article-title":"T-type voltage-gated calcium channels as targets for\nthe development of novel pain therapies","volume":"163","author":"Todorovic","year":"2011","journal-title":"Br.\nJ. Pharmacol."},{"key":"2026090402071020200_cit45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/jama.280.2.157","article-title":"Life-threatening interaction of mibefradil and beta-blockers with\ndihydropyridine calcium channel blockers","volume":"280","author":"Mullins","year":"1998","journal-title":"JAMA,\nJ. Am. Med. Assoc."},{"key":"2026090402071020200_cit46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1152\/physrev.00023.2013","article-title":"Calcium-permeable ion channels in pain signaling","volume":"94","author":"Bourinet","year":"2014","journal-title":"Physiol. Rev."},{"key":"2026090402071020200_cit47","doi-asserted-by":"crossref","first-page":"8766","DOI":"10.1523\/JNEUROSCI.2527-05.2005","article-title":"The endogenous\nredox agent L-cysteine induces T-type Ca2+ channel-dependent\nsensitization of a novel subpopulation of rat peripheral nociceptors","volume":"25","author":"Nelson","year":"2005","journal-title":"J. Neurosci."},{"key":"2026090402071020200_cit48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pain.2012.10.023","article-title":"State-dependent properties of a new\nT-type calcium channel blocker enhance Ca(V)3.2 selectivity and support\nanalgesic effects","volume":"154","author":"Francois","year":"2013","journal-title":"Pain"},{"key":"2026090402071020200_cit49","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuron.2014.03.016","article-title":"Neuronal Voltage-Gated Calcium Channels:\nStructure,\nFunction, and Dysfunction","volume":"82","author":"Simms","year":"2014","journal-title":"Neuron"},{"key":"2026090402071020200_cit50","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1074\/jbc.R400030200","article-title":"Mining the receptorome","volume":"280","author":"Armbruster","year":"2005","journal-title":"J. Biol.\nChem."},{"key":"2026090402071020200_cit51","doi-asserted-by":"crossref","first-page":"420","DOI":"10.2174\/138620708784911483","article-title":"Massively\nparallel screening of the receptorome","volume":"11","author":"Jensen","year":"2008","journal-title":"Comb.\nChem. High Throughput Screening"},{"key":"2026090402071020200_cit52","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.drudis.2006.06.012","article-title":"Screening the receptorome: an efficient\napproach for drug discovery and target validation","volume":"11","author":"Strachan","year":"2006","journal-title":"Drug Discovery Today"},{"key":"2026090402071020200_cit53","doi-asserted-by":"crossref","first-page":"20171","DOI":"10.1074\/jbc.M300581200","article-title":"Determinants of inhibition of transiently expressed\nvoltage-gated calcium channels by omega-conotoxins GVIA and MVIIA","volume":"278","author":"Feng","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2026090402071020200_cit54","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-2999(80)90515-4","article-title":"Intrathecal morphine in mice: A new technique","volume":"67","author":"Hylden","year":"1980","journal-title":"Eur. J. Pharmacol."},{"key":"2026090402071020200_cit55","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1744-8069-7-59","article-title":"Cellular prion protein protects from inflammatory and\nneuropathic pain","volume":"7","author":"Gadotti","year":"2011","journal-title":"Mol. Pain"},{"key":"2026090402071020200_cit56","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neuropharm.2011.08.018","article-title":"Depressive-like\nbehavior induced by tumor necrosis factor-alpha in mice","volume":"62","author":"Kaster","year":"2012","journal-title":"Neuropharmacology"},{"key":"2026090402071020200_cit57","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0304-3959(98)00045-1","article-title":"Partial sciatic nerve injury in the mouse as a model\nof neuropathic pain: Behavioral and neuroanatomical correlates","volume":"76","author":"Malmberg","year":"1998","journal-title":"Pain"}],"container-title":["ACS Chemical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cn500206a","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acncdm\/article-pdf\/6\/2\/277\/8041625\/cn500206a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acncdm\/article-pdf\/6\/2\/277\/8041625\/cn500206a.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:25:28Z","timestamp":1788510328000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acncdm\/article\/6\/2\/277\/783967\/Characterization-of-Novel-Cannabinoid-Based-T-Type"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,14]]},"references-count":57,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,10,14]]},"published-print":{"date-parts":[[2015,2,18]]}},"URL":"https:\/\/doi.org\/10.1021\/cn500206a","relation":{},"ISSN":["1948-7193"],"issn-type":[{"value":"1948-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,14]]}}}