{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:21:12Z","timestamp":1788470472566,"version":"build-2803163510"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2015,11,22]],"date-time":"2015-11-22T00:00:00Z","timestamp":1448150400000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1 R41 NS080278"],"award-info":[{"award-number":["1 R41 NS080278"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["SDG5280023"],"award-info":[{"award-number":["SDG5280023"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The functionalized amino acid, lacosamide ((R)-2), and the \u03b1-aminoamide, safinamide ((S)-3), are neurological agents that have been extensively investigated and have displayed potent anticonvulsant activities in seizure models. Both compounds have been reported to modulate voltage-gated sodium channel activity. We have prepared a series of chimeric compounds, (R)-7\u2013(R)-10, by merging key structural units in these two clinical agents, and then compared their activities with (R)-2 and (S)-3. Compounds were assessed for their ability to alter sodium channel kinetics for inactivation, frequency (use)-dependence, and steady-state activation and fast inactivation. We report that chimeric compounds (R)-7\u2013(R)-10 in catecholamine A-differentiated (CAD) cells and embryonic rat cortical neurons robustly enhanced sodium channel inactivation at concentrations far lower than those required for (R)-2 and (S)-3, and that (R)-9 and (R)-10, unlike (R)-2 and (S)-3, produce sodium channel frequency (use)-dependence at low micromolar concentrations. We further show that (R)-7\u2013(R)-10 displayed excellent anticonvulsant activities and pain-attenuating properties in the animal formalin model. Of these compounds, only (R)-7 reversed mechanical hypersensitivity in the tibial-nerve injury model for neuropathic pain in rats.<\/jats:p>","DOI":"10.1021\/cn5002182","type":"journal-article","created":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T11:51:23Z","timestamp":1416657083000},"page":"316-330","source":"Crossref","is-referenced-by-count":16,"title":["Chimeric Agents Derived from the Functionalized Amino\nAcid, Lacosamide, and the \u03b1-Aminoamide, Safinamide: Evaluation\nof Their Inhibitory Actions on Voltage-Gated Sodium Channels, and\nAntiseizure and Antinociception Activities and Comparison with Lacosamide\nand Safinamide"],"prefix":"10.1021","volume":"6","author":[{"given":"Ki Duk","family":"Park","sequence":"first","affiliation":[{"name":"University of North Carolina , , , ,","place":["Chapel Hill, North Carolina, United States, 27599"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"University of Arizona , , , ,","place":["Tucson, Arizona, United States, 85742"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik T.","family":"Dustrude","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine , , , ,","place":["Indianapolis, Indiana, United States, 46202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Arizona , , , ,","place":["Tucson, Arizona, United States, 85742"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Ripsch","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine , , , ,","place":["Indianapolis, Indiana, United States, 46202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fletcher A.","family":"White","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine , , , ,","place":["Indianapolis, Indiana, United States, 46202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Khanna","sequence":"additional","affiliation":[{"name":"University of Arizona , , , ,","place":["Tucson, Arizona, United States, 85742"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Kohn","sequence":"additional","affiliation":[{"name":"University of North Carolina , , , ,","place":["Chapel Hill, North Carolina, United States, 27599"]},{"name":"University of North Carolina , , , ,","place":["Chapel Hill, North Carolina, United States, 27599"]},{"name":"NeuroGate Therapeutics, Inc. , 150 Fayetteville Street, Suite 2300 , , ,","place":["Raleigh, North Carolina, United States, 27601"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,11,22]]},"reference":[{"key":"2026090316434611600_cit1","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1021\/jm100185c","article-title":"Merging the structural\nmotifs of functionalized amino acids and \u03b1-aminoamides: compounds\nwith significant anticonvulsant activities","volume":"53","author":"Salome","year":"2010","journal-title":"J. Med. Chem."},{"key":"2026090316434611600_cit2","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1021\/jm9508705","article-title":"Synthesis and anticonvulsant activities\nof N-benzyl-2-acetamidopropionamide derivatives","volume":"39","author":"Choi","year":"1996","journal-title":"J. Med. Chem."},{"key":"2026090316434611600_cit3","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1021\/jm970599m","article-title":"Synthesis and anticonvulsant\nactivity of a new class of 2-[(arylalkyl)amino]alkanamide derivatives","volume":"41","author":"Pevarello","year":"1998","journal-title":"J. Med. Chem."},{"key":"2026090316434611600_cit4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nrd2764","article-title":"Lacosamide","volume":"7","author":"Perucca","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"2026090316434611600_cit5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0022-3565(24)37430-0","article-title":"Preclinical\nevaluation of PNU-151774E as a novel anticonvulsant","volume":"285","author":"Fariello","year":"1998","journal-title":"J. Pharm. Exp. Therap."},{"key":"2026090316434611600_cit6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1468-1331.2012.03840.x","article-title":"Long-term\nefficacy and safety of safinamide as add-on therapy in early Parkinson\u2019s\ndisease","volume":"20","author":"Schapira","year":"2013","journal-title":"Eur. J. Neurol."},{"key":"2026090316434611600_cit7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1124\/mol.107.039867","article-title":"The investigational\nanticonvulsant lacosamide selectively enhances slow inactivation of\nvoltage-gated sodium channels","volume":"73","author":"Errington","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"2026090316434611600_cit8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1124\/jpet.107.133413","article-title":"Differential block\nof sensory neuronal voltage-gated sodium channels by lacosamide, lidocaine\nand carbamazepine","volume":"326","author":"Sheets","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090316434611600_cit9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1021\/cn100089b","article-title":"Development and characterization\nof novel derivatives of the antiepileptic drug lacosamide that exhibit\nfar greater enhancement in slow inactivation of voltage-gated sodium\nchannels","volume":"2","author":"Wang","year":"2011","journal-title":"ACS Chem. Neurosci."},{"key":"2026090316434611600_cit10","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0022-3565(24)38068-1","article-title":"Biochemical\nand electrophysiological\nstudies on the mechanism of action of PNU-151774E, a novel antiepileptic\ncompound","volume":"288","author":"Salvati","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090316434611600_cit11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1021\/cn200024z","article-title":"Merging structural\nmotifs of functionalized amino acids and \u03b1-aminoamides results\nin novel anticonvulsant compounds with significant effects on slow\nand fast inactivation of voltage-gated sodium channels and in the\ntreatment of neuropathic pain","volume":"2","author":"Wang","year":"2011","journal-title":"ACS Chem. Neurosci."},{"key":"2026090316434611600_cit12","first-page":"99","article-title":"General principles: Experimental\nselection, quantification, and evaluation\nof antiepileptic drugs","volume-title":"Antiepileptic Drugs","author":"White","year":"1995","edition":"4"},{"key":"2026090316434611600_cit13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.eplepsyres.2007.03.004","article-title":"Lacosamide, a novel\nanticonvulsant drug, shows efficacy with a wide safety margin in rodent\nmodels for epilepsy","volume":"74","author":"Stoehr","year":"2007","journal-title":"Epilepsy Res."},{"key":"2026090316434611600_cit14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/00001756-200003200-00002","article-title":"An animal model\nof neuropathic pain employing injury to the sciatic nerve branches","volume":"11","author":"Lee","year":"2000","journal-title":"NeuroReport"},{"key":"2026090316434611600_cit15","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1152\/jn.2000.84.6.2888","article-title":"Voltage-dependent ion channels in CAD cells: A catecholaminergic\nneuronal line that exhibits inducible differentiation","volume":"84","author":"Wang","year":"2000","journal-title":"J. Neurophysiol."},{"key":"2026090316434611600_cit16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0920-1211(01)00302-3","article-title":"Pharmacological\ncharacterization of the 6 Hz psychomotor seizure model of partial\nepilepsy","volume":"47","author":"Barton","year":"2001","journal-title":"Epilepsy Res."},{"key":"2026090316434611600_cit17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","article-title":"The formalin\ntest: An evaluation of the method","volume":"51","author":"Tjolsen","year":"1992","journal-title":"Pain"},{"key":"2026090316434611600_cit18","doi-asserted-by":"crossref","first-page":"5012","DOI":"10.1021\/ja00995a032","article-title":"A reinvestigation of the mixed anhydride\nmethod of peptide synthesis","volume":"89","author":"Anderson","year":"1967","journal-title":"J. Am. Chem. Soc."},{"key":"2026090316434611600_cit19","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1021\/jm00024a006","article-title":"Selective\nand potent monoamine oxidase\ntype B inhibitors: 2-substituted 5-aryltetrazole derivatives","volume":"38","author":"Lebreton","year":"1995","journal-title":"J. Med. Chem."},{"key":"2026090316434611600_cit20","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.1016\/j.bmc.2013.10.031","article-title":"Benzyloxybenzylammonium\nchlorides: Simple amine salts that display anticonvulsant activity","volume":"21","author":"Lee","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"2026090316434611600_cit21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-12-507701-9.50013-9","article-title":"Nuclear magnetic\nresonance analysis using chiral solvating agents","volume-title":"Asymmetric Synthesis-Analytical\nMethods","author":"Weisman","year":"1983"},{"key":"2026090316434611600_cit22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/1568026053386872","article-title":"Voltage gated ion channels: Targets\nfor anticonvulsant drugs","volume":"5","author":"Errington","year":"2005","journal-title":"Curr. Top. Med. Chem."},{"key":"2026090316434611600_cit23","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1021\/jm500707r","article-title":"Substituted N-(Biphenyl-4\u2032-yl)methyl (R)-2-acetamido-3-methoxypropionamides:\nPotent anticonvulsants that affect frequency (use)-dependence and\nslow inactivation of sodium channels","volume":"57","author":"Lee","year":"2014","journal-title":"J. Med.\nChem."},{"key":"2026090316434611600_cit24","doi-asserted-by":"crossref","first-page":"25296","DOI":"10.1074\/jbc.M110.128801","article-title":"In silico docking and\nelectrophysiological characterization\nof lacosamide binding sites on collapsin response mediator protein\n2 (CRMP-2) identifies a pocket important in modulating sodium channel\nslow inactivation","volume":"285","author":"Wang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2026090316434611600_cit25","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1021\/cn300129d","article-title":"Identification\nof the benzyloxyphenyl pharmacophore: A structural unit that promotes\nsodium channel slow inactivation","volume":"3","author":"King","year":"2012","journal-title":"ACS Chem.\nNeurosci."},{"key":"2026090316434611600_cit26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrn3404","article-title":"The NaV 1.7 sodium\nchannel from molecule to man","volume":"14","author":"Dib-Hajj","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"2026090316434611600_cit27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1146\/annurev.physiol.63.1.871","article-title":"Resurgence\nof sodium channel research","volume":"63","author":"Goldin","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"2026090316434611600_cit28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/pr.57.4.4","article-title":"International\nUnion of Pharmacology.\nXLVII. Nomenclature and structure-function relationships of voltage-gated\nsodium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharm. Rev."},{"key":"2026090316434611600_cit29","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0026-895X(25)09804-9","article-title":"Slow binding of phenytoin to inactivated\nsodium channels\nin rat hippocampal neurons","volume":"46","author":"Kuo","year":"1994","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"2026090316434611600_cit30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1124\/mol.113.088492","article-title":"Ranolazine reduces neuronal hyperexcitability\nby interacting with inactivated states of brain sodium channels","volume":"85","author":"Kahlig","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"2026090316434611600_cit31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1113\/jphysiol.1952.sp004719","article-title":"The dual effect of membrane potential on sodium conductance\nin the giant axon of Loligo","volume":"116","author":"Hodgkin","year":"1952","journal-title":"J. Physiol."},{"key":"2026090316434611600_cit32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1978.sp012485","article-title":"Slow inactivation\nof the sodium conductance in squid giant axons. Pronase resistance","volume":"283","author":"Rudy","year":"1978","journal-title":"J. Physiol."},{"key":"2026090316434611600_cit33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrn2148","article-title":"The action\npotential in mammalian central neurons","volume":"8","author":"Bean","year":"2007","journal-title":"Nat.\nRev. Neurosci."},{"key":"2026090316434611600_cit34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0896-6273(03)00360-X","article-title":"Subthreshold sodium\ncurrents and pacemaking of subthalamic\nneurons: Modulation by slow inactivation","volume":"39","author":"Do","year":"2003","journal-title":"Neuron"},{"key":"2026090316434611600_cit35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1385\/CBB:35:2:171","article-title":"Slow inactivation\nin voltage-gated sodium channels:\nMolecular substrates and contributions to channelopathies","volume":"35","author":"Vilin","year":"2001","journal-title":"Cell Biochem. Biophys."},{"key":"2026090316434611600_cit36","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1021\/jm4007092","article-title":"(Biphenyl-4-yl)methylammonium chlorides:\nPotent anticonvulsants that modulate Na+ currents","volume":"56","author":"Lee","year":"2013","journal-title":"J. Med. Chem."},{"key":"2026090316434611600_cit37","first-page":"191","article-title":"The NIH Anticonvulsant\nDrug Development (ADD) program: Preclinical anticonvulsant screening\nproject","volume-title":"Molecular\nand Cellular Targets for Antiepileptic Drugs","author":"Stables","year":"1997"},{"key":"2026090316434611600_cit38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3949\/ccjm.51.2.293","article-title":"Antiepileptic drug development program","volume":"51","author":"Porter","year":"1984","journal-title":"Cleveland Clin. Q."},{"key":"2026090316434611600_cit39","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jps.3030460322","article-title":"A note on a simple apparatus for detecting neurological\ndeficit in rats and mice","volume":"46","author":"Dunham","year":"1957","journal-title":"J. Am. Pharm. Assoc."},{"key":"2026090316434611600_cit40","first-page":"36","article-title":"General Principles: Discovery\nand Preclinical Development of Antiepileptic\nDrugs","volume-title":"Antiepileptic Drugs","author":"White","year":"2002","edition":"5"},{"key":"2026090316434611600_cit41","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1528-1157.1969.tb03838.x","article-title":"Laboratory\nevaluation of antiepileptic drugs: Review of laboratory methods","volume":"10","author":"Swinyard","year":"1969","journal-title":"Epilepsia"},{"key":"2026090316434611600_cit42","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1021\/jm901563p","article-title":"Synthesis and anticonvulsant\nactivities of (R)-N-(4\u2032-substituted)benzyl\n2-acetamido-3-methoxypropionamides","volume":"53","author":"Salome","year":"2010","journal-title":"J. Med.\nChem."},{"key":"2026090316434611600_cit43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0304-3959(77)90130-0","article-title":"The formalin\ntest: A quantitative study of the analgesic\neffects of morphine, meperidine, and brain stem stimulation in rats\nand cats","volume":"4","author":"Dubuisson","year":"1977","journal-title":"Pain"},{"key":"2026090316434611600_cit44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF02244551","article-title":"Standardization of the rat paw formalin test for the evaluation of\nanalgesics","volume":"104","author":"Wheeler-Aceto","year":"1991","journal-title":"Psychopharmacology"},{"key":"2026090316434611600_cit45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0304-3959(94)00095-V","article-title":"The formalin\ntest: Scoring properties\nof the first and second phases of the pain response in rats","volume":"60","author":"Abbott","year":"1995","journal-title":"Pain"},{"key":"2026090316434611600_cit46","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejpain.2005.04.002","article-title":"Lacosamide\ndisplays potent antinociceptive\neffects in animal models for inflammatory pain","volume":"10","author":"Stohr","year":"2006","journal-title":"Eur. J. Pain."},{"key":"2026090316434611600_cit47","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejphar.2005.01.030","article-title":"The anti-nociceptive\nagent ralfinamide inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive\nNa+ currents in dorsal root ganglion neurons","volume":"510","author":"Stummann","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"2026090316434611600_cit48","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/1742-2094-9-180","article-title":"The persistent\nrelease of HMGB1 contributes to tactile hyperalgesia in a rodent model\nof neuropathic pain","volume":"9","author":"Feldman","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"2026090316434611600_cit49","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/jnc.12070","article-title":"Suppression\nof pain-related behavior in two distinct rodent models of peripheral\nneuropathy by a homopolyarginine-conjugated CRMP2 peptide","volume":"124","author":"Ju","year":"2012","journal-title":"J. Neurochem."},{"key":"2026090316434611600_cit50","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1744-8069-3-38","article-title":"Delayed functional expression of\nneuronal chemokine receptors following focal nerve demyelination in\nthe rat: a mechanism for the development of chronic sensitization\nof peripheral nociceptors","volume":"3","author":"Bhangoo","year":"2007","journal-title":"Mol. Pain"},{"key":"2026090316434611600_cit51","doi-asserted-by":"crossref","first-page":"31375","DOI":"10.1074\/jbc.M109.009951","article-title":"An atypical role for collapsing response mediator protein\n2 (CRMP-2) in neurotransmitter release via interaction with presynaptic\nvoltage-gated Ca2+ channels","volume":"284","author":"Brittain","year":"2009","journal-title":"J. Biol.\nChem."},{"key":"2026090316434611600_cit52","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1016\/j.febslet.2012.09.022","article-title":"Cdk5-mediated phosphorylation\nof CRMP-2 enhances its interaction with CaV2.2","volume":"586","author":"Brittain","year":"2012","journal-title":"FEBS Lett."}],"container-title":["ACS Chemical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cn5002182","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acncdm\/article-pdf\/6\/2\/316\/8042051\/cn5002182.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acncdm\/article-pdf\/6\/2\/316\/8042051\/cn5002182.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:43:57Z","timestamp":1788468237000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acncdm\/article\/6\/2\/316\/784009\/Chimeric-Agents-Derived-from-the-Functionalized"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,22]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,11,22]]},"published-print":{"date-parts":[[2015,2,18]]}},"URL":"https:\/\/doi.org\/10.1021\/cn5002182","relation":{},"ISSN":["1948-7193"],"issn-type":[{"value":"1948-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,22]]}}}