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This study aimed to comprehensively assess the association between exposure to multiple PCPs and serum lipid profiles in healthy older adults and to explore underlying molecular pathways and biological mechanisms. We conducted a prospective panel study with five monthly follow-up surveys between September 2018 and January 2019 among 76 healthy older adults (60\u201369 years) in Jinan, China. This study measured urinary concentrations of PCPs, serum lipid markers, and multiomics profiles (transcriptomics, lipidomics, and metabolomics). We employed linear mixed-effects models to analyze exposure-outcome associations and integrated multiomics data with causal inference testing and Ingenuity Pathway Analysis to identify mediating biomolecules and biological mechanisms. Additional analyses examined the relationships of PCP exposures with inflammatory cytokines, oxidative stress biomarkers, and electrocardiographic (ECG) parameters to provide functional support for the identified pathways and their associated phenotypic consequences. Four PCPs [Benzophenone-2 (BP-2), Benzophenone-3 (BP-3), 4-Hydroxy benzophenone (4-OHBP), and Ethyl p-Hydroxybenzoate (EtP)] were significantly associated with altered serum lipid profiles. Multiomics analyses suggested their convergence on a PPAR-centered immunometabolic network, with S100 signaling identified as a novel activation pathway. Specifically, BP-2 was associated with patterns consistent with IL-4\/IL-13-mediated alternative macrophage activation, while PPAR appeared to be involved in inflammatory polarization and metabolic reprogramming. Cytokine analysis revealed associations between BP-2 and key inflammatory mediators (e.g., IL-1\u03b2), oxidative stress assessment linked BP-2 exposure to elevated markers of oxidative damage (e.g., 8-PGF2\u03b1), and ECG analysis associated BP-2 exposure with altered cardiac electrophysiology (e.g., QRS duration). These multifaceted findings suggest associations between PCP exposures and serum lipid profiles, and highlight the potential contribution to cardiovascular risk. Our findings provide integrated, multilayered evidence suggesting associations between exposure to PCPs and alterations in serum lipid profiles in older adults, bridging exposure profiles, biomolecular perturbations, and subclinical functional changes. These results serve as a hypothesis-generating theoretical foundation that, pending confirmation in larger studies or experimental validation, advances the understanding of environmental metabolic disruption in aging populations.<\/jats:p>","DOI":"10.1021\/ehp.6c00011","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:57:48Z","timestamp":1783011468000},"page":"624-638","source":"Crossref","is-referenced-by-count":1,"title":["Multiomics Insights\nLinking Personal Care Products\nExposure to Serum Lipid Profiles in Older Adults: The China BAPE Study"],"prefix":"10.1021","volume":"134","author":[{"given":"Yongjun","family":"Situ","sequence":"first","affiliation":[{"name":"Southern Medical University , , , ,","place":["Guangzhou, Guangdong, China, 510515"]},{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Guo","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Guangzhou Center for Disease Control and Prevention (Guangzhou Health Supervision Institute) , , ,","place":["Guangzhou, Guangdong, China, 510440"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Ren","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Southeast University , , , ,","place":["Nanjing, Jiangsu, China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankun","family":"Qian","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlong","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Cheeloo College of Medicine, Shandong University , , , ,","place":["Jinan, Shandong, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Cheeloo College of Medicine, Shandong University , , , ,","place":["Jinan, Shandong, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwen","family":"Tang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Nanjing Medical University , , , ,","place":["Nanjing, Jiangsu, China, 211166"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Cheeloo College of Medicine, Shandong University , , , ,","place":["Jinan, Shandong, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Nanjing Medical University , , , ,","place":["Nanjing, Jiangsu, China, 211166"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liang","sequence":"additional","affiliation":[{"name":"Southern Medical University , , , ,","place":["Guangzhou, Guangdong, China, 510515"]},{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglei","family":"Qi","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyue","family":"Shao","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Cheeloo College of Medicine, Shandong University , , , ,","place":["Jinan, Shandong, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2809-7110","authenticated-orcid":true,"given":"Hongyang","family":"Cui","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"National Institute of Environmental Health, Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 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