{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:46:55Z","timestamp":1791838015287,"version":"4.3.4"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"the CAMS Innovation Fund for Medical Sciences","award":["2025-I2M-XHXX-177"],"award-info":[{"award-number":["2025-I2M-XHXX-177"]}]},{"name":"the Science and Technology Projects of Xizang Autonomous Region, China","award":["XZ202501ZY0072"],"award-info":[{"award-number":["XZ202501ZY0072"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>With the intensification of climate change, temperature variability (TV), a critical climatic dimension, is projected to increase. As a climate-sensitive disease, ischemic stroke may be affected by temperature variability; however, the evidence on the ischemic stroke burdens of short-term temperature variability in a changing climate remains unknown, especially accounting for long-term exposure adaptation. Based on a nationally representative, multicenter data set of over 1.6 million individual-level, hourly data on ischemic stroke onset from 2015 to 2022, we adopted a case-crossover study design to evaluate the association between short-term exposure to TV and ischemic stroke onset using conditional logistic regression. Furthermore, we took the long-term TV adaptation into account to derive the modified nonlinear exposure-response function and evaluated the ischemic stroke burden under different climate change scenarios. Short-term exposure to TV was positively associated with the risk of ischemic stroke onset, and long-term TV significantly modified the effects with populations living in regions of persistently high TV being more vulnerable. The ischemic stroke cases attributable to TV have more than doubled from 2000 to 2020. Under the high-emission scenario (SSP5-8.5), the attributable fraction of ischemic stroke is projected to increase substantially (19\u201358%) by the end of the century, particularly in vulnerable regions such as Southwest and South China. These findings demonstrate that individuals have limited adaptive capacity to temperature variability. Incorporating temperature variability into climate\u2013health risk assessments, public health preparedness, and mitigation strategies will be essential to safeguard populations in an increasingly unstable climate system.<\/jats:p>","DOI":"10.1021\/ehp.6c00173","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:02:08Z","timestamp":1790344928000},"page":"715-725","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the Burden of\nIschemic Stroke Attributable\nto Temperature Variation under Climate Change Scenarios Accounting\nfor Long-Term Adaptation"],"prefix":"10.1021","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2315-7679","authenticated-orcid":true,"given":"Zhaoyang","family":"Pan","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8066-0175","authenticated-orcid":true,"given":"Hailu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100730"]},{"name":"Henan Key Laboratory of Chronic Disease Management, Fuwai Central China Cardiovascular Hospital, Henan Cardiovascular Disease Center (Central China Subcenter of National Center for Cardiovascular Diseases), Central China Fuwai Hospital of Zhengzhou University, Henan Provincial Cardiovascular Hospital , No. 1 Fuwai Road, Zhengdong New District , ,","place":["Zhengzhou, China, 451464"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewei","family":"Xie","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-3685","authenticated-orcid":true,"given":"Linhong","family":"Pang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-9747","authenticated-orcid":true,"given":"Zijun","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Complex Severe and Rare Diseases , ,","place":["Beijing, China, 100730"]},{"name":"Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , ,","place":["Beijing, China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]},{"name":"National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]},{"name":"National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiao","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]},{"name":"National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University , ,","place":["Beijing, China, 100071"]},{"name":"Chinese Academy of Medical Sciences , , ,","place":["Beijing, China, 100071"]},{"name":"Chinese Institute for Brain Research , ,","place":["Beijing, China, 102206"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Rao","sequence":"additional","affiliation":[{"name":"Central South University , , ,","place":["Changsha, China, 410078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjia","family":"Guan","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , , ,","place":["Beijing, China, 100071"]},{"name":"Chinese Academy of Medical Sciences , , ,","place":["Beijing, China, 100071"]},{"name":"Chinese Institute for Brain Research , ,","place":["Beijing, China, 102206"]},{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200031"]},{"name":"Capital Medical University , , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2026101215564640800_cit1","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1038\/s41591-023-02438-w","article-title":"Climate change and\nhealth: three grand challenges","volume":"29","author":"Campbell-Lendrum","year":"2023","journal-title":"Nat. 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