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E.","year":"2007"},{"key":"ref154\/cit154","volume-title":"Report on Carcinogens, Fifteenth ed.","author":"NTP","year":"2021"},{"key":"ref155\/cit155","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-10-9"},{"key":"ref156\/cit156","volume-title":"Living healthily in a chemical world","author":"EEA","year":"2020"},{"key":"ref157\/cit157","volume-title":"Inventory of existing EBD, HIA, exposure and exposure-effect data for chemicals prioritized in PARC","author":"Buekers J.","year":"2023"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1206154"},{"key":"ref159\/cit159","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2011.10.048"},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14111359"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.02.023"},{"key":"ref162\/cit162","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.114308"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2018.12.042"},{"key":"ref164\/cit164","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4323"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4326"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2873"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4324"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30275-3"},{"key":"ref169\/cit169","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110666"},{"key":"ref170\/cit170","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2017.11.004"},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.1175\/BAMS-D-21-0314.1"},{"key":"ref172\/cit172","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2016.04.081"},{"key":"ref173\/cit173","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2015.12.017"},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.3c00633"},{"key":"ref175\/cit175","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110874"},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2023.114139"},{"key":"ref177\/cit177","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2021.113704"},{"key":"ref178\/cit178","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-7-S1-S12"},{"key":"ref179\/cit179","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.120084"},{"key":"ref180\/cit180","doi-asserted-by":"crossref","unstructured":"Schullehner, J.; Donat, C.; Crippa, A.; Chambers, T.; Sigsgaard, T.; Villanueva, C. M.\n                      Overview of systematic reviews and exposure-response functions on nitrate in drinking water and colorectal cancer\n                      , ISEE Conference Abstracts, 2024.","DOI":"10.1289\/isee.2024.0453"},{"key":"ref181\/cit181","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-021-01501-1"},{"key":"ref182\/cit182","doi-asserted-by":"publisher","DOI":"10.1177\/18333583221106509"},{"key":"ref183\/cit183","volume-title":"Morbidity statistics in the EU. Report on pilot studies \u2013 2023 ed.","author":"Eurostat","year":"2024"},{"key":"ref184\/cit184","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17699"},{"key":"ref185\/cit185","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz169"},{"key":"ref186\/cit186","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16224474"},{"key":"ref187\/cit187","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2014.08.034"},{"key":"ref188\/cit188","doi-asserted-by":"publisher","DOI":"10.3390\/w15122185"},{"key":"ref189\/cit189","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-018-0310-y"},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.109464"},{"key":"ref191\/cit191","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18052375"},{"key":"ref192\/cit192","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107178"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2022.120828"},{"key":"ref194\/cit194","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1283087"},{"key":"ref195\/cit195","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/74.2.325"},{"key":"ref196\/cit196","first-page":"71","volume":"2","author":"Collins J. J.","year":"1998","journal-title":"Scandinavian J. Work, Environ. Health"},{"key":"ref197\/cit197","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.5.316"},{"key":"ref198\/cit198","unstructured":"NCI. Bioassay of 1,\n2-dichloroethane for possible carcinogenicity. In\n                      National Cancer Institute carcinogenesis technical report series\n                      , 1978; Vol. 55, pp 1\u2013103."},{"key":"ref199\/cit199","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105974"},{"key":"ref200\/cit200","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-015-0690-y"},{"key":"ref201\/cit201","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99688-w"},{"key":"ref202\/cit202","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.115239"},{"key":"ref203\/cit203","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02232-6"},{"key":"ref204\/cit204","doi-asserted-by":"publisher","DOI":"10.1007\/s11869-024-01619-x"},{"key":"ref205\/cit205","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-13536-y"},{"key":"ref206\/cit206","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.137832"},{"key":"ref207\/cit207","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-022-01963-y"},{"key":"ref208\/cit208","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-1093-0"},{"key":"ref209\/cit209","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030666"},{"key":"ref210\/cit210","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-27345-x"},{"key":"ref211\/cit211","unstructured":"HEI. Systematic Review\nand Meta-Analysis of Selected Health Effects of Long-Term Exposure\nto Traffic-Related Air Pollution. In\n                      HEI Special\nReport 23\n                      2022."},{"key":"ref212\/cit212","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.120215"},{"key":"ref213\/cit213","unstructured":"Anderson, H.; Atkinson, R.; Bremner, S.; Carrington, J.; Peacock, J. Quantitative systematic review of short term associations between ambient air pollution (particulate matter, ozone, nitrogen dioxide, sulphur dioxide and carbon monoxide), and mortality and morbidity. In\n                      Report to Department of Health revised following first review\n                      2007."},{"key":"ref214\/cit214","doi-asserted-by":"publisher","DOI":"10.23749\/mdl.v111i1.8967"},{"key":"ref215\/cit215","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-023-01748-1"},{"key":"ref216\/cit216","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph110404449"},{"key":"ref217\/cit217","doi-asserted-by":"publisher","DOI":"10.23749\/mdl.v114i5.15065"},{"key":"ref218\/cit218","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.116362"},{"key":"ref219\/cit219","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-023-28592-9"},{"key":"ref220\/cit220","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2021.113904"},{"key":"ref221\/cit221","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-022-00464-3"},{"key":"ref222\/cit222","doi-asserted-by":"publisher","DOI":"10.1289\/EHP11112"},{"key":"ref223\/cit223","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1295"},{"key":"ref224\/cit224","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00808-4"}],"container-title":["Environment & Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/envhealth.4c00277","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/envhealth.4c00277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:12:35Z","timestamp":1758269555000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/envhealth.4c00277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":223,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,19]]}},"alternative-id":["10.1021\/envhealth.4c00277"],"URL":"https:\/\/doi.org\/10.1021\/envhealth.4c00277","relation":{},"ISSN":["2833-8278","2833-8278"],"issn-type":[{"value":"2833-8278","type":"print"},{"value":"2833-8278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]}}}