{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:56:49Z","timestamp":1792796209985,"version":"4.5.0"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202312275"],"award-info":[{"award-number":["tsqn202312275"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22376215"],"award-info":[{"award-number":["22376215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20618"],"award-info":[{"award-number":["U22A20618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MD071"],"award-info":[{"award-number":["ZR2023MD071"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yantai Special Supporting Funds for Leading Talents above Provincial Level"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Health"],"published-print":{"date-parts":[[2026,6,19]]},"DOI":"10.1021\/envhealth.5c00503","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:58:41Z","timestamp":1769518721000},"page":"1227-1240","source":"Crossref","is-referenced-by-count":1,"title":["Exploring Toxicological Mechanisms of Typical PFAS-Induced NAFLD through Integrated Computational Toxicology and AOP Frameworks"],"prefix":"10.1021","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-0835","authenticated-orcid":true,"given":"Fei","family":"Li","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security","place":["Yantai, China"]},{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security","place":["Yantai, China"]},{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences","place":["Yantai, China"]},{"name":"School of Pharmacy","place":["Yantai, China"]},{"name":"Binzhou Medical University","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security","place":["Yantai, China"]},{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences","place":["Yantai, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security","place":["Yantai, China"]},{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Ji","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security","place":["Yantai, China"]},{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4042-8103","authenticated-orcid":true,"given":"Huifeng","family":"Wu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security","place":["Yantai, China"]},{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0273-8"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107251"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108235"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094807"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114836"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-018-0094-1"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c04855"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117642"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2015.12.024"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.126361"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b02259"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.04.052"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.6b00260"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106824"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/awwa.1073"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b00829"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117436"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-024-01865-5"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.123937"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11120965"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.138208"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-023-26941-2"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-0872-7"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111036"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2019.01.017"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310798"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2020.104797"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1289\/EHP6233"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134337"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.109053"},{"key":"ref31\/cit31","unstructured":"OECD. 2018. Users\u2019\nHandbook supplement\nto the guidance document for developing and assessing adverse outcome\npathways. https:\/\/www.oecd.org\/en\/publications\/users-handbook-supplement-to-the-guidance-document-for-developing-and-assessing-adverse-outcome-pathways_5jlv1m9d1g32-en.html (accessed 2 December 2025)."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2024.153955"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.0c09196"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/etc.4124"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx097"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.174450"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.173420"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.eehl.2024.08.002"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.170679"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.02.017"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-97670-4"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.122109"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00702"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-4-2"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102849"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/jm0401560"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0109"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.638536"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00006.2013"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47635-2"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2022.08.004"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6613827"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.149"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082199"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2024.153862"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202400598"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.89568"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01036-7"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03003-w"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4020249"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b01714"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2025.110318"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.160087"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101428"}],"container-title":["Environment & Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/envhealth.5c00503","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/envhealth.5c00503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:11:16Z","timestamp":1781856676000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/envhealth.5c00503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,19]]}},"alternative-id":["10.1021\/envhealth.5c00503"],"URL":"https:\/\/doi.org\/10.1021\/envhealth.5c00503","relation":{},"ISSN":["2833-8278","2833-8278"],"issn-type":[{"value":"2833-8278","type":"print"},{"value":"2833-8278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]}}}