{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T15:26:13Z","timestamp":1787412373250,"version":"build-2736575974"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073597"],"award-info":[{"award-number":["82073597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241086"],"award-info":[{"award-number":["82241086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diesel exhaust (DE), as a principal contributor to traffic-related air pollution, poses significant public and occupational health risks. The lung microbiome could be shaped by inhaled pollutants, which play a crucial role in sustaining pulmonary health. Our prior study found a lower abundance of airway Prevotella nanceiensis (P.nan.) in DE-exposed individuals. Here, in this study, live P.nan. and its bacterial extracellular vesicles (BEVs) alleviated lung damage under inhaled DE exposure, accompanied by reduced neutrophil infiltration and activation. Notably, DE triggered lipid droplet accumulation in the lung, mitigated by the live P.nan.\/BEVs intervention. Additionally, inhibitors targeting lipid oxidation, synthesis, and transport attenuated neutrophil activation in response to diesel exhaust particle (DEP) stimulation. Moreover, the intervention of BEVs resulted in decreased levels of inflammatory mediators, neutrophil recruitment-associated chemokines, and lipid-related genes. This study highlights live P.nan.\/BEVs\u2019 protective role against DE-induced lung injury, implicating neutrophil recruitment and lipid metabolism as key mechanisms and offering potential therapeutic avenues.<\/jats:p>","DOI":"10.1021\/envhealth.5c00648","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T17:05:44Z","timestamp":1776359144000},"page":"1790-1803","source":"Crossref","is-referenced-by-count":1,"title":["Live Airway\n                    <i>Prevotella<\/i>\n                    Attenuated\nDiesel Exhaust-Induced Lung Injury and Neutrophil Activation via Bacterial\nExtracellular Vesicles"],"prefix":"10.1021","volume":"4","author":[{"given":"Bojia","family":"Wang","sequence":"first","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Cai","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4660-7150","authenticated-orcid":true,"given":"Qixiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2759-0827","authenticated-orcid":true,"given":"Hongna","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmei","family":"Piao","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, China, 266011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-7616","authenticated-orcid":true,"given":"Menghui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"issue":"7655","key":"2026082211084731800_cit1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nature22086","article-title":"Impacts and mitigation of excess\ndiesel-related NO(x) emissions in 11 major vehicle markets","volume":"545","author":"Anenberg","year":"2017","journal-title":"Nature"},{"issue":"8","key":"2026082211084731800_cit2","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3109\/08958371003758823","article-title":"Diesel\nexhaust particulate (DEP) and nanoparticle exposures: what do DEP\nhuman clinical studies tell us about potential human health hazards\nof nanoparticles?","volume":"22","author":"Hesterberg","year":"2010","journal-title":"Inhal. Toxicol."},{"key":"2026082211084731800_cit3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.taap.2019.01.010","article-title":"Time-course\neffects of antioxidants and phase II enzymes\non diesel exhaust particles-induced oxidative damage in the mouse\nlung","volume":"366","author":"Zheng","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"2026082211084731800_cit4","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1002\/jat.2925","article-title":"Obese mice are resistant\nto eosinophilic airway inflammation induced by diesel exhaust particles","volume":"34","author":"Yanagisawa","year":"2014","journal-title":"J. Appl. 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