{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:10:18Z","timestamp":1789744218015,"version":"4.0.1"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241087"],"award-info":[{"award-number":["82241087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373618"],"award-info":[{"award-number":["82373618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["824B2100"],"award-info":[{"award-number":["824B2100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Indium tin oxide (ITO) particles, widely utilized in electronics and energy technologies, pose significant pulmonary risks due to occupational exposure during manufacturing. While emerging evidence links ITO to severe lung pathologies, critical gaps persist in understanding size-dependent effects and molecular mechanisms. This study systematically investigates the size-dependent effects of nanoscale ITO (N-ITO) and submicron-scale ITO (U-ITO) on pulmonary toxicity, focusing on ferroptosis as a key mechanism. In vivo, repeated oropharyngeal exposure of mice to ITO (3.6 and 36 mg\/kg) induced dose-dependent lung inflammation and ferroptosis, marked by lipid peroxidation, Fe2+ accumulation, and dysregulation of Gpx4 and Scl7a11 proteins, with pulmonary macrophages identified as primary targets. In vitro, THP-1 macrophages exposed to 6.25\u201325 \u03bcg\/mL ITO exhibited size-dependent cytotoxicity, inflammation, and ferroptotic hallmarks. Mechanistically, ITO-triggered ferroptosis promoted HMGB1 secretion and nuclear translocation, which activated the RAGE\/p38MAPK pathway, amplifying inflammatory responses. Notably, N-ITO induced stronger ferroptosis and inflammation than U-ITO, correlating with enhanced macrophage uptake due to its nanoscale dimensions. Integrating these findings, we propose an Adverse Outcome Pathway (AOP) framework for ITO-induced lung injury, which cellular uptake may serve as the molecular initiating event and link ferroptosis-driven high mobility group protein B1 (HMGB1) release, RAGE\/p38MAPK activation, and chronic inflammation to adverse pulmonary outcomes. This study underscores the necessity of size-specific occupational exposure limits for ITO nanoparticles and provides a mechanistic foundation for risk assessment and management strategies in occupational settings.<\/jats:p>","DOI":"10.1021\/envhealth.5c00667","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:03:45Z","timestamp":1777597425000},"page":"1910-1929","source":"Crossref","is-referenced-by-count":0,"title":["Role of Cellular-Ferroptosis-Mediated\nHMGB1 Nuclear\nTranslocation in Indium-Tin-Oxide-Nanoparticle-Induced Inflammatory\nLung Injury"],"prefix":"10.1021","volume":"4","author":[{"given":"Yueyue","family":"Mu","sequence":"first","affiliation":[{"name":"Southeast University , , ,","place":["Nanjing, China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Wu","sequence":"additional","affiliation":[{"name":"Southeast University , , ,","place":["Nanjing, China, 210009"]},{"name":"China Railway Shanghai Bureau Group Co., Ltd. Shanghai Railway Center for Disease Control and Prevention , ,","place":["Shanghai, China, 200040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Ding","sequence":"additional","affiliation":[{"name":"Southeast University , , ,","place":["Nanjing, China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Pang","sequence":"additional","affiliation":[{"name":"Southeast University , , ,","place":["Nanjing, China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Cao","sequence":"additional","affiliation":[{"name":"Southeast University , , ,","place":["Nanjing, China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qu","sequence":"additional","affiliation":[{"name":"Southeast University , , ,","place":["Nanjing, China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haopeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Southeast University , , ,","place":["Nanjing, China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Southeast University , , ,","place":["Nanjing, China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-9754","authenticated-orcid":true,"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Southeast University , , ,","place":["Nanjing, China, 210009"]},{"name":"Southeast University , , ,","place":["Nanjing, China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"issue":"22","key":"2026091808071451200_cit1","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1063\/1.118761","article-title":"Triple-junction amorphous silicon\nalloy solar cell with 14.6% initial and 13.0% stable conversion efficiencies","volume":"70","author":"Yang","year":"1997","journal-title":"Appl. Phys. Lett."},{"issue":"4","key":"2026091808071451200_cit2","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1021\/cr050149z","article-title":"Conjugated polymer-based organic\nsolar cells","volume":"107","author":"Gu\u0308nes","year":"2007","journal-title":"Chem Rev"},{"issue":"4","key":"2026091808071451200_cit3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nnano.2008.418","article-title":"Bottom-up\ngrowth of fully transparent contact layers\nof indium tin oxide nanowires for light-emitting devices","volume":"4","author":"O\u2019Dwyer","year":"2009","journal-title":"Nat Nanotechnol"},{"issue":"10","key":"2026091808071451200_cit4","doi-asserted-by":"publisher","first-page":"8026","DOI":"10.1021\/nn2025836","article-title":"Three-dimensional\nnanobranched indium-tin-oxide anode for organic solar cells","volume":"5","author":"Yu","year":"2011","journal-title":"ACS Nano"},{"issue":"2","key":"2026091808071451200_cit5","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/23\/2\/025706","article-title":"Low-temperature\nsynthesis of indium\ntin oxide nanowires as the transparent electrodes for organic light\nemitting devices","volume":"23","author":"Kee","year":"2012","journal-title":"Nanotechnology"},{"issue":"9","key":"2026091808071451200_cit6","first-page":"39","article-title":"Preparation and\nCharacteristics of ITO Thin Films","volume":"24","author":"Rongsheng","year":"2005","journal-title":"Electron.\nCompon. Mater."},{"issue":"3","key":"2026091808071451200_cit7","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3390\/biom11030419","article-title":"Assessment\nof Occupational Exposure to Indium Dust for Indium-Tin-Oxide Manufacturing\nWorkers","volume":"11","author":"Kim","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"2026091808071451200_cit8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1136\/oem.2006.029124","article-title":"Exposure to\nhardly soluble indium compounds in ITO\nproduction and recycling plants is a new risk for interstitial lung\ndamage","volume":"65","author":"Hamaguchi","year":"2008","journal-title":"Occup Environ Med"},{"issue":"5","key":"2026091808071451200_cit9","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1378\/chest.13-2484","article-title":"Five-year\ncohort study:\nemphysematous progression of indium-exposed workers","volume":"146","author":"Nakano","year":"2014","journal-title":"Chest"},{"issue":"3","key":"2026091808071451200_cit10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1539\/joh.10-0057-OA","article-title":"Inhalation carcinogenicity and chronic toxicity\nof indium-tin oxide in rats and mice","volume":"53","author":"Nagano","year":"2011","journal-title":"J Occup\nHealth"},{"issue":"5","key":"2026091808071451200_cit11","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and\nfunctions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"2026091808071451200_cit12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev-bioeng-062117-121224","article-title":"Mechanobiology\nof Macrophages: How\nPhysical Factors Coregulate Macrophage Plasticity and Phagocytosis","volume":"21","author":"Jain","year":"2019","journal-title":"Annu Rev Biomed Eng"},{"issue":"1","key":"2026091808071451200_cit13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41418-018-0179-3","article-title":"Programmed\nNecrosis and Disease:We\ninterrupt your regular programming to bring you necroinflammation","volume":"26","author":"Kim","year":"2019","journal-title":"Cell Death Differ."},{"issue":"2","key":"2026091808071451200_cit14","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bbrc.2019.01.090","article-title":"The release and activity\nof HMGB1 in ferroptosis","volume":"510","author":"Wen","year":"2019","journal-title":"Biochem. Biophys. Res.\nCommun."},{"issue":"24","key":"2026091808071451200_cit15","doi-asserted-by":"publisher","first-page":"6294","DOI":"10.3390\/ijms20246294","article-title":"High Mobility Group Box 1 and TLR4 Signaling Pathway in Gnotobiotic\nPiglets Colonized\/Infected with L. amylovorus, L. mucosae, E. coli\nNissle 1917 and S. Typhimurium","volume":"20","author":"Splichal","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2026091808071451200_cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1676941","article-title":"Involvement of HMGB1-mediated\nferroptosis in systemic diseases","volume":"13","author":"Lv","year":"2025","journal-title":"Front. Cell\nDev. Biol."},{"issue":"3","key":"2026091808071451200_cit17","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/etc.34","article-title":"Adverse outcome pathways: a conceptual framework\nto support ecotoxicology research and risk assessment","volume":"29","author":"Ankley","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"issue":"11","key":"2026091808071451200_cit18","doi-asserted-by":"publisher","first-page":"3477","DOI":"10.1007\/s00204-017-2045-3","article-title":"Adverse\noutcome pathways: opportunities, limitations\nand open questions","volume":"91","author":"Leist","year":"2017","journal-title":"Arch. Toxicol."},{"issue":"9","key":"2026091808071451200_cit19","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1021\/envhealth.5c00053","article-title":"Integrating\nDisease Data and Toxicology Studies to Uncover the Mechanisms of Indium\nTin Oxide (ITO) Nanoparticle-Induced Pulmonary Fibrosis and Develop\nan Adverse Outcome Pathway (AOP) Framework","volume":"3","author":"Zhang","year":"2025","journal-title":"Environment & Health"},{"issue":"1\u20132","key":"2026091808071451200_cit20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2533\/chimia.2019.55","article-title":"Artificial Lysosomal Platform to\nStudy Nanoparticle\nLong-term Stability","volume":"73","author":"MilosevicAc","year":"2019","journal-title":"Chimia (Aarau)"},{"issue":"1","key":"2026091808071451200_cit21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12989-017-0193-5","article-title":"Reduction of pulmonary\ntoxicity of metal oxide nanoparticles by phosphonate-based surface\npassivation","volume":"14","author":"Cai","year":"2017","journal-title":"Part Fibre Toxicol."},{"issue":"6","key":"2026091808071451200_cit22","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1530\/REP-09-0247","article-title":"Inflammatory\npathways\nin female reproductive health and disease","volume":"138","author":"Jabbour","year":"2009","journal-title":"Reproduction"},{"issue":"5","key":"2026091808071451200_cit23","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.778","article-title":"The N6-methyladenosine\nmodification enhances ferroptosis resistance\nthrough inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma","volume":"12","author":"Liu","year":"2022","journal-title":"Clin. Transl. Med."},{"issue":"51","key":"2026091808071451200_cit24","doi-asserted-by":"publisher","first-page":"15716","DOI":"10.1021\/acs.jafc.1c05393","article-title":"T-2 Toxin Induces Ferroptosis by\nIncreasing Lipid Reactive Oxygen Species (ROS) and Downregulating\nSolute Carrier Family 7 Member 11 (SLC7A11)","volume":"69","author":"Wang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"2026091808071451200_cit25","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.901565","article-title":"Post-Translational\nModification of\nGPX4 is a Promising Target for Treating Ferroptosis-Related Diseases","volume":"9","author":"Cui","year":"2022","journal-title":"Front Mol Biosci"},{"key":"2026091808071451200_cit26","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin\nresistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu. Rev. Physiol."},{"issue":"45","key":"2026091808071451200_cit27","doi-asserted-by":"publisher","first-page":"53671","DOI":"10.1021\/acsami.1c18061","article-title":"Targeting Ferroptosis by Polydopamine\nNanoparticles Protects Heart against Ischemia\/Reperfusion Injury","volume":"13","author":"Zhang","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"issue":"12","key":"2026091808071451200_cit28","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.3390\/cells10123323","article-title":"Post-Translational\nModification of\nHMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation","volume":"10","author":"Andersson","year":"2021","journal-title":"Cells"},{"issue":"10","key":"2026091808071451200_cit29","doi-asserted-by":"publisher","first-page":"Fso828","DOI":"10.2144\/fsoa-2022-0052","article-title":"Reappraisal of oxidized\nHMGB1 as a mediator and biomarker","volume":"8","author":"Pirnie","year":"2022","journal-title":"Future Sci\nOA"},{"key":"2026091808071451200_cit30","doi-asserted-by":"publisher","first-page":"w13256","DOI":"10.4414\/smw.2011.13256","article-title":"Cell death\nin the pathogenesis of immune-mediated diseases: the role of HMGB1\nand DAMP-PAMP complexes","volume":"141","author":"Pisetsky","year":"2011","journal-title":"Swiss Med Wkly"},{"key":"2026091808071451200_cit31","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/716481","article-title":"ATF3 Protects against\nLPS-Induced Inflammation in Mice\nvia Inhibiting HMGB1 Expression","volume":"2013","author":"Lai","year":"2013","journal-title":"Evid. Based\nComplementaryAltern. Med."},{"issue":"4","key":"2026091808071451200_cit32","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1159\/000430320","article-title":"Escin Increases the\nSurvival Rate of LPS-Induced Septic\nMice Through Inhibition of HMGB1 Release from Macrophages","volume":"36","author":"Cheng","year":"2015","journal-title":"Cell Physiol Biochem"},{"issue":"1\u20132","key":"2026091808071451200_cit33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s11010-015-2396-0","article-title":"HMGB1 binding\nto receptor for advanced\nglycation end products enhances inflammatory responses of human bronchial\nepithelial cells by activating p38 MAPK and ERK1\/2","volume":"405","author":"Liang","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"4","key":"2026091808071451200_cit34","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1159\/000495651","article-title":"Ectodomain\nShedding of RAGE and TLR4 as a Negative Feedback Regulation in High-Mobility\nGroup Box 1-Activated Aortic Endothelial Cells","volume":"51","author":"Yang","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"10","key":"2026091808071451200_cit35","doi-asserted-by":"publisher","first-page":"6244","DOI":"10.4049\/jimmunol.0900390","article-title":"HMGB1 enhances\nthe proinflammatory\nactivity of lipopolysaccharide by promoting the phosphorylation of\nMAPK p38 through receptor for advanced glycation end products","volume":"183","author":"Qin","year":"2009","journal-title":"J Immunol"},{"issue":"1","key":"2026091808071451200_cit36","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/2052-4374-25-24","article-title":"Subclinical interstitial\nlung damage in workers exposed\nto indium compounds","volume":"25","author":"Choi","year":"2013","journal-title":"Ann Occup Environ Med"},{"issue":"1","key":"2026091808071451200_cit37","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/ajim.22402","article-title":"Interstitial lung\ndisorders in the indium workers of\nKorea: an update study for the relationship with biological exposure\nindices","volume":"58","author":"Choi","year":"2015","journal-title":"Am J Ind Med"},{"issue":"4","key":"2026091808071451200_cit38","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1164\/ajrccm.182.4.578","article-title":"Pulmonary alveolar\nproteinosis in workers at an indium processing\nfacility","volume":"182","author":"Lison","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"2026091808071451200_cit39","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1539\/joh.10-0053-BR","article-title":"Pulmonary toxicity in mice by 2-\nand 13-week inhalation exposures to indium-tin oxide and indium oxide\naerosols","volume":"53","author":"Nagano","year":"2011","journal-title":"J Occup Health"},{"issue":"1","key":"2026091808071451200_cit40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.5487\/TR.2014.30.1.055","article-title":"Studies on the toxicity\nand distribution of indium compounds according to particle size in\nsprague-dawley rats","volume":"30","author":"Lim","year":"2014","journal-title":"Toxicol Res"},{"issue":"2","key":"2026091808071451200_cit41","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.jfma.2020.08.009","article-title":"Case reports\nof indium lung disease\nin Taiwan","volume":"120","author":"Tsao","year":"2021","journal-title":"J Formos Med Assoc"},{"issue":"1","key":"2026091808071451200_cit42","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13000-023-01303-1","article-title":"A case report of Indium lung with progressive emphysema\nand fibrosis underwent lung unilateral transplantation 20 years after\nthe end of the exposure","volume":"18","author":"Inoue","year":"2023","journal-title":"Diagn. Pathol."},{"issue":"1","key":"2026091808071451200_cit43","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12989-022-00510-w","article-title":"Pulmonary effects of\nexposure to indium and its compounds: cross-sectional survey of exposed\nworkers and experimental findings in rodents","volume":"19","author":"Liu","year":"2022","journal-title":"Part. Fibre Toxicol."},{"issue":"7","key":"2026091808071451200_cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e28364","article-title":"Plumbagin induces ferroptosis\nin colon cancer cells by regulating p53-related SLC7A11 expression","volume":"10","author":"Wang","year":"2024","journal-title":"Heliyon"},{"key":"2026091808071451200_cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.146460","article-title":"Sinapine induced\nferroptosis in non-small cell lung cancer cells by upregulating transferrin\/transferrin\nreceptor and downregulating SLC7A11","volume":"827","author":"Shao","year":"2022","journal-title":"Gene"},{"issue":"6","key":"2026091808071451200_cit46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001393","article-title":"Comparative\nanalysis\nof proteome and transcriptome variation in mouse","volume":"7","author":"Ghazalpour","year":"2011","journal-title":"PLoS Genet"},{"issue":"11","key":"2026091808071451200_cit47","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.3390\/genes14112065","article-title":"Workability\nof mRNA Sequencing for Predicting Protein Abundance","volume":"14","author":"Ponomarenko","year":"2023","journal-title":"Genes (Basel)"},{"key":"2026091808071451200_cit48","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence\nthe macrophage m1-m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front.\nImmunol."},{"key":"2026091808071451200_cit49","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.lfs.2018.03.058","article-title":"Titanium dioxide nanoparticle stimulating pro-inflammatory\nresponses\nin vitro and in vivo for inhibited cancer metastasis","volume":"202","author":"Zhao","year":"2018","journal-title":"Life Sci"},{"issue":"5","key":"2026091808071451200_cit50","doi-asserted-by":"publisher","first-page":"919","DOI":"10.3390\/polym14050919","article-title":"Evaluation of the\nPerformance of\na ZnO-Nanoparticle-Coated Hydrocolloid Patch in Wound Healing","volume":"14","author":"Le","year":"2022","journal-title":"Polymers (Basel)"},{"key":"2026091808071451200_cit51","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3824593","article-title":"Investigation of Cytotoxicity, Oxidative Stress,\nand Inflammatory Responses of Tantalum Nanoparticles in THP-1-Derived\nMacrophages","volume":"2020","author":"Zhang","year":"2020","journal-title":"Mediators Inflamm."},{"issue":"2","key":"2026091808071451200_cit52","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3109\/03602532.2013.873450","article-title":"Porcine\nbrain microvessel\nendothelial cells show pro-inflammatory response to the size and composition\nof metallic nanoparticles","volume":"46","author":"Trickler","year":"2014","journal-title":"Drug Metab Rev"},{"issue":"11","key":"2026091808071451200_cit53","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23190","article-title":"Hepcidin regulates neuronal ferroptosis:\nA mechanism for postoperative cognitive dysfunction","volume":"36","author":"Shen","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"3","key":"2026091808071451200_cit54","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41419-020-2384-5","article-title":"\u2033Iron\nfree\u2033 zinc oxide nanoparticles with ion-leaking properties\ndisrupt intracellular ROS and iron homeostasis to induce ferroptosis","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"2026091808071451200_cit55","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1021\/envhealth.5c00251","article-title":"PM2.5 Induced Iron Accumulation-Associated\nHepatocyte Toxicity and\nMice Liver Injury via Activation of Ferroptosis and Pyroptosis","volume":"4","author":"Yan","year":"2026","journal-title":"Environment & Health"},{"issue":"1","key":"2026091808071451200_cit56","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s12672-023-00691-6","article-title":"Tetrandrine\ncitrate suppresses lung adenocarcinoma growth via SLC7A11\/GPX4-mediated\nferroptosis","volume":"14","author":"Mo","year":"2023","journal-title":"Discovery Oncol."},{"key":"2026091808071451200_cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.149274","article-title":"Gigantol exerts anti-lung\ncancer activity by inducing\nferroptosis via SLC7A11-GPX4 axis","volume":"690","author":"Chen","year":"2024","journal-title":"Biochem.\nBiophys. Res. Commun."},{"key":"2026091808071451200_cit58","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/978-1-4939-8931-7_8","article-title":"Alarmin Detection in Senescent Cells","volume":"1896","author":"Kim","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"2026091808071451200_cit59","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00441-010-1033-1","article-title":"High-mobility group\nbox 1 (HMGB1) as a master regulator of innate immunity","volume":"343","author":"Castiglioni","year":"2011","journal-title":"Cell Tissue Res"},{"key":"2026091808071451200_cit60","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.3389\/fimmu.2020.01189","article-title":"Immunological Significance\nof HMGB1 Post-Translational\nModification and Redox Biology","volume":"11","author":"Kwak","year":"2020","journal-title":"Front. Immunol."},{"issue":"5","key":"2026091808071451200_cit61","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1159\/000358696","article-title":"Resveratrol reduces the proinflammatory effects\nand lipopolysaccharide-\ninduced expression of HMGB1 and TLR4 in RAW264.7 cells","volume":"33","author":"Yang","year":"2014","journal-title":"Cell Physiol Biochem"},{"issue":"3","key":"2026091808071451200_cit62","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1111\/liv.15811","article-title":"Ferritinophagy-mediated\nferroptosis facilitates methotrexate-induced\nhepatotoxicity by high-mobility group box 1 (HMGB1)","volume":"44","author":"Wang","year":"2024","journal-title":"Liver Int"},{"issue":"6894","key":"2026091808071451200_cit63","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1\nby necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"issue":"51","key":"2026091808071451200_cit64","doi-asserted-by":"publisher","first-page":"39888","DOI":"10.1074\/jbc.M110.128348","article-title":"High mobility group box 1 release\nfrom hepatocytes during ischemia and reperfusion injury is mediated\nby decreased histone deacetylase activity","volume":"285","author":"Evankovich","year":"2010","journal-title":"J.\nBiol. Chem."},{"issue":"1","key":"2026091808071451200_cit65","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s10020-020-00224-9","article-title":"The \u03b17 nicotinic\nacetylcholine receptor agonist GTS-21 improves bacterial clearance\nin mice by restoring hyperoxia-compromised macrophage function","volume":"26","author":"Sitapara","year":"2020","journal-title":"Mol. Med."},{"issue":"24","key":"2026091808071451200_cit66","doi-asserted-by":"publisher","first-page":"21671","DOI":"10.1021\/acs.jmedchem.4c01912","article-title":"Targeting\nHMGB1 and Its Interaction with Receptors: Challenges and Future Directions","volume":"67","author":"Shen","year":"2024","journal-title":"J. Med. Chem."},{"issue":"3","key":"2026091808071451200_cit67","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.bbrc.2020.04.127","article-title":"Identification\nof the hallmarks of necroptosis and ferroptosis by transmission electron\nmicroscopy","volume":"527","author":"Miyake","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"21","key":"2026091808071451200_cit68","doi-asserted-by":"publisher","first-page":"7311","DOI":"10.3390\/molecules27217311","article-title":"Therapeutic Potential of Targeting the HMGB1\/RAGE Axis\nin Inflammatory Diseases","volume":"27","author":"Singh","year":"2022","journal-title":"Molecules"},{"key":"2026091808071451200_cit69","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3389\/fnins.2018.00628","article-title":"HMGB1: A Common Biomarker\nand Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive\nDysfunction","volume":"12","author":"Paudel","year":"2018","journal-title":"Front. Neurosci."},{"issue":"11","key":"2026091808071451200_cit70","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1002\/ajmg.a.36181","article-title":"Perspectives on RAGE signaling and\nits role in cardiovascular\ndisease","volume":"161a","author":"Cohen","year":"2013","journal-title":"Am J Med Genet A"},{"issue":"2","key":"2026091808071451200_cit71","doi-asserted-by":"publisher","first-page":"E155","DOI":"10.1073\/pnas.1522288113","article-title":"Critical\nrole of RAGE\nand HMGB1 in inflammatory heart disease","volume":"113","author":"Bangert","year":"2016","journal-title":"Proc\nNatl Acad Sci U S A"},{"key":"2026091808071451200_cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109005","article-title":"HMGB1\/RAGE pro-inflammatory\naxis promotes vascular endothelial cell apoptosis in limb ischemia\/reperfusion\ninjury","volume":"116","author":"Mi","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"2026091808071451200_cit73","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1089\/ped.2017.0846","article-title":"HMGB1 Binding\nto the RAGE Receptor Contributes to the Pathogenesis of Asthma","volume":"31","author":"Li","year":"2018","journal-title":"Pediatric Allergy Immunology and Pulmonology"}],"container-title":["Environment &amp; Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/envhealth.5c00667","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ehnea2\/article-pdf\/4\/9\/1910\/62999025\/envhealth.5c00667.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ehnea2\/article-pdf\/4\/9\/1910\/62999025\/envhealth.5c00667.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:52:45Z","timestamp":1789743165000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ehnea2\/article\/4\/9\/1910\/5068513\/Role-of-Cellular-Ferroptosis-Mediated-HMGB1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":73,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,4,30]]},"published-print":{"date-parts":[[2026,9,18]]}},"URL":"https:\/\/doi.org\/10.1021\/envhealth.5c00667","relation":{},"ISSN":["2833-8278"],"issn-type":[{"value":"2833-8278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}