{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:04:48Z","timestamp":1789747488855,"version":"4.0.1"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ60520"],"award-info":[{"award-number":["2025JJ60520"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019092","name":"Science Fund for Distinguished Young Scholars of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ2082"],"award-info":[{"award-number":["2024JJ2082"]}],"id":[{"id":"10.13039\/501100019092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42277438"],"award-info":[{"award-number":["42277438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Changsha Natural Science Foundation","award":["Kq2502043"],"award-info":[{"award-number":["Kq2502043"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cooking oil fumes (COFs), a major source of indoor air pollutants, are responsible for approximately 90% of indoor particulate matter emissions. Trans,trans-2,4-decadienal (tt-DDE), the predominant aldehyde in COFs, exhibits established mutagenic and carcinogenic potential. Although CHRFAM7A remains to be validated as a cardiovascular therapeutic target, accumulating evidence positions it as a novel modulator of the cardiovascular pathophysiology. This study explored the protective mechanisms of CHRFAM7A against the tt-DDE-induced vascular injury. First, inhalation of tt-DDE was observed to elevate blood pressure, an effect attributed to associated endothelial cell damage. Additionally, we found that CHRFAM7A-transgenic mice exhibit significant resistance to tt-DDE-induced systolic hypertension and endothelial dysfunction. Mechanistically, the observed protection was attributed to the STAT3\/HO-1 pathway activation. Moreover, in vitro revealed that tt-DDE promotes KLF5-driven inflammatory responses through METTL3-dependent m6A modification, effects that were mitigated by CHRFAM7A overexpression. Notably, inhibition of HO-1 could abolish CHRFAM7A-mediated regulation of METTL3-dependent KLF5 translation. Collectively, these results identify CHRFAM7A as a molecular safeguard against tt-DDE-induced vascular pathology, functioning through coordinated regulation of the STAT3\/HO-1\/METTL3 signaling. This work thus provides new therapeutic insights for cardiovascular disorders associated with COF exposure.<\/jats:p>","DOI":"10.1021\/envhealth.5c00703","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T14:48:34Z","timestamp":1779461314000},"page":"2055-2068","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Mechanisms\nof Indoor Environmental Pollution\ntt-DDE-Induced Blood Pressure Elevation and the Protective Role of\nHuman-Specific Gene CHRFAM7A"],"prefix":"10.1021","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-134X","authenticated-orcid":true,"given":"Siwen","family":"Li","sequence":"first","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Su","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Fang","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzi","family":"Ye","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemei","family":"Liu","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchang","family":"Wang","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-1227","authenticated-orcid":true,"given":"Fang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"issue":"10397","key":"2026091808071526000_cit1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, Regional, and National Burden of Diabetes from 1990 to 2021,\nwith Projections of Prevalence to 2050: a Systematic Analysis for\nthe Global Burden of Disease Study 2021","volume":"402","author":"GBD 2021 Diabetes Collaborators.","year":"2023","journal-title":"Lancet"},{"issue":"22","key":"2026091808071526000_cit2","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.117.032380","article-title":"Status of Hypertension in China: Results from the China Hypertension\nSurvey, 2012\u20132015","volume":"137","author":"Wang","year":"2018","journal-title":"Circulation"},{"issue":"9","key":"2026091808071526000_cit3","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cjca.2023.07.002","article-title":"Impact of Environmental\nFactors on Hypertension and Associated Cardiovascular Disease","volume":"39","author":"Rios","year":"2023","journal-title":"Canadian journal of cardiology"},{"issue":"49","key":"2026091808071526000_cit4","doi-asserted-by":"publisher","first-page":"74688","DOI":"10.1007\/s11356-022-21113-0","article-title":"Maternal Exposure\nto Cooking Oil Fumes During Pregnancy and Autistic-like Behaviors\nin Chinese Preschoolers","volume":"29","author":"Yang","year":"2022","journal-title":"Environ. Sci. Pollut\nRes. Int."},{"key":"2026091808071526000_cit5","doi-asserted-by":"publisher","first-page":"133151","DOI":"10.1016\/j.chemosphere.2021.133151","article-title":"Effects of Household Cooking with\nClean Energy on the Risk for Hypertension\namong Women in Beijing","volume":"289","author":"Liu","year":"2022","journal-title":"Chemosphere"},{"key":"2026091808071526000_cit6","doi-asserted-by":"publisher","first-page":"104933","DOI":"10.1016\/j.tiv.2020.104933","article-title":"Trans, trans-2,4-decadienal (tt-DDE), a Composition\nof Cooking Oil\nFumes, Induces Oxidative Stress and Endoplasmic Reticulum Stress in\nHuman Corneal Epithelial Cells","volume":"68","author":"Yan","year":"2020","journal-title":"Toxicol. 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Leukoc Biol."},{"issue":"3","key":"2026091808071526000_cit30","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s10753-020-01398-4","article-title":"CHRFAM7A Overexpression\nAttenuates\nCerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis\nMediated by the NLRP3\/Caspase-1 pathway","volume":"44","author":"Cao","year":"2021","journal-title":"Inflammation"},{"issue":"1","key":"2026091808071526000_cit31","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/jcmm.17630","article-title":"Up-regulation of the\nHuman-specific CHRFAM7A gene Protects against Renal Fibrosis in Mice\nwith Obstructive Nephropathy","volume":"27","author":"Zhou","year":"2023","journal-title":"J. Cell. 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Pharmacol."},{"issue":"2","key":"2026091808071526000_cit38","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.bbadis.2017.10.021","article-title":"Regulatory Crosstalk between KLF5,\nmiR-29a and Fbw7\/CDC4 Cooperatively Promotes Atherosclerotic Development","volume":"1864","author":"Zheng","year":"2018","journal-title":"Biochim Biophys Acta Mol. Basis Dis"},{"key":"2026091808071526000_cit39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.molimm.2024.03.007","article-title":"KLF5-mediated Pyroptosis of Airway\nEpithelial Cells Leads to Airway Inflammation in Asthmatic Mice through\nthe miR-182\u20135p\/TLR4 axis","volume":"170","author":"Lin","year":"2024","journal-title":"Mol. Immunol."},{"key":"2026091808071526000_cit40","doi-asserted-by":"publisher","first-page":"113503","DOI":"10.1016\/j.ecoenv.2022.113503","article-title":"Paraquat-induced Oxidative\nStress Regulates N6-methyladenosine m6A Modification of Long Noncoding\nRNAs in Neuro-2a cells","volume":"237","author":"Su","year":"2022","journal-title":"Ecotoxicol Environ.\nSaf"},{"issue":"4","key":"2026091808071526000_cit41","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1021\/es203376x","article-title":"Concentrations and\nComposition Profiles of Benzotriazole UV Stabilizers in Municipal\nSewage Sludge in China","volume":"46","author":"Ruan","year":"2012","journal-title":"Environ. Sci. 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Med."}],"container-title":["Environment &amp; Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/envhealth.5c00703","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ehnea2\/article-pdf\/4\/9\/2055\/66262401\/envhealth.5c00703.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ehnea2\/article-pdf\/4\/9\/2055\/66262401\/envhealth.5c00703.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:10:26Z","timestamp":1789744226000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ehnea2\/article\/4\/9\/2055\/5232884\/Molecular-Mechanisms-of-Indoor-Environmental"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":42,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5,22]]},"published-print":{"date-parts":[[2026,9,18]]}},"URL":"https:\/\/doi.org\/10.1021\/envhealth.5c00703","relation":{},"ISSN":["2833-8278"],"issn-type":[{"value":"2833-8278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]}}}