{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:15:50Z","timestamp":1792034150914,"version":"4.4.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"19","license":[{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Using seawater for toilet flushing may introduce high levels of bromide and iodide into a city\u2019s sewage treatment works, and result in the formation of brominated and iodinated disinfection byproducts (DBPs) during chlorination to disinfect sewage effluents. In a previous study, the authors\u2019 group has detected the presence of many brominated DBPs and identified five new aromatic brominated DBPs in chlorinated saline sewage effluents. The presence of brominated DBPs in chlorinated saline effluents may pose adverse implications for marine ecology. In this study, besides the detection and identification of another seven new aromatic halogenated DBPs in a chlorinated saline sewage effluent, their developmental toxicity was evaluated using the marine polychaete Platynereis dumerilii. For comparison, the developmental toxicity of some commonly known halogenated DBPs was also examined. The rank order of the developmental toxicity of 20 halogenated DBPs was 2,5-dibromohydroquinone &amp;gt; 2,6-diiodo-4-nitrophenol \u2265 2,4,6-triiodophenol &amp;gt; 4-bromo-2-chlorophenol \u2265 4-bromophenol &amp;gt; 2,4-dibromophenol \u2265 2,6-dibromo-4-nitrophenol &amp;gt; 2-bromo-4-chlorophenol &amp;gt; 2,6-dichloro-4-nitrophenol &amp;gt; 2,4-dichlorophenol &amp;gt; 2,4,6-tribromophenol &amp;gt; 3,5-dibromo-4-hydroxybenzaldehyde &amp;gt; bromoform \u2265 2,4,6-trichlorophenol &amp;gt; 2,6-dibromophenol &amp;gt; 2,6-dichlorophenol &amp;gt; iodoacetic acid \u2265 tribromoacetic acid &amp;gt; bromoacetic acid &amp;gt; chloroacetic acid. On the basis of developmental toxicity data, a quantitative structure\u2013activity relationship (QSAR) was established. The QSAR involved two physical\u2013chemical property descriptors (log P and pKa) and two electronic descriptors (the lowest unoccupied molecular orbital energy and the highest occupied molecular orbital energy) to indicate the transport, biouptake, and biointeraction of these DBPs. It can well predict the developmental toxicity of most of the DBPs tested.<\/jats:p>","DOI":"10.1021\/es401841t","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T13:20:50Z","timestamp":1378905650000},"page":"10868-10876","source":"Crossref","is-referenced-by-count":580,"title":["Comparative Developmental Toxicity of New Aromatic\nHalogenated DBPs in a Chlorinated Saline Sewage Effluent to the Marine\nPolychaete\n                    <i>Platynereis dumerilii<\/i>"],"prefix":"10.1021","volume":"47","author":[{"given":"Mengting","family":"Yang","sequence":"first","affiliation":[{"name":"The Hong Kong University of Science and Technology , , Hong Kong SAR ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangru","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Hong Kong University of Science and Technology , , Hong Kong SAR ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,9,11]]},"reference":[{"key":"2026081802132442800_cit1","volume-title":"Engineering and\nCosts of Dual Water Supply Systems","author":"Tang","year":"2007"},{"issue":"21","key":"2026081802132442800_cit2","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1021\/es9015124","article-title":"Covariation and photoinactivation\nof traditional and\nnovel indicator organisms and human viruses at a sewage-impacted marine\nbeach","volume":"43","author":"Boehm","year":"2009","journal-title":"Environ. 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Technol."},{"key":"2026081802132442800_cit8","unstructured":"Hong Kong 2030:\nPlanning Vision and Strategy \u2013 Strategic Environmental\nAssessment; No. CE25\/2001; Planning Department\nof the Government of the Hong Kong SAR: Hong Kong, 2007; http:\/\/www.epd.gov.hk\/epd\/SEA\/eng\/file\/FinalSEAReport.pdf."},{"issue":"19","key":"2026081802132442800_cit9","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1016\/j.watres.2005.08.033","article-title":"DBP formation\nin breakpoint chlorination\nof wastewater","volume":"39","author":"Yang","year":"2005","journal-title":"Water Res."},{"issue":"9","key":"2026081802132442800_cit10","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.watres.2009.02.033","article-title":"Effect of bromide on\nthe formation of disinfection by-products during wastewater chlorination","volume":"43","author":"Sun","year":"2009","journal-title":"Water Res."},{"issue":"21","key":"2026081802132442800_cit11","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.1021\/es901611m","article-title":"Occurrence\nof disinfection byproducts in United States wastewater treatment plant\neffluents","volume":"43","author":"Krasner","year":"2009","journal-title":"Environ. 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Technol."},{"issue":"8","key":"2026081802132442800_cit13","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1016\/j.watres.2013.02.036","article-title":"Formation\nof new brominated\ndisinfection byproducts during chlorination of saline sewage effluents","volume":"47","author":"Ding","year":"2013","journal-title":"Water Res."},{"issue":"6","key":"2026081802132442800_cit14","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1021\/es1034427","article-title":"Formation and decomposition of new and unknown polar brominated disinfection\nbyproducts during chlorination","volume":"45","author":"Zhai","year":"2011","journal-title":"Environ. 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Mutagen."},{"issue":"6","key":"2026081802132442800_cit17","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1021\/es051602r","article-title":"Modulation of the cytotoxicity and genotoxicity of\nthe drinking water disinfection byproduct iodoacetic acid by suppressors\nof oxidative stress","volume":"40","author":"Cemeli","year":"2006","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"2026081802132442800_cit18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1021\/es030477l","article-title":"Halonitromethane\ndrinking water disinfection\nbyproducts: Chemical characterization and mammalian cell cytotoxicity\nand genotoxicity","volume":"38","author":"Plewa","year":"2004","journal-title":"Environ. Sci. 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Sci. Technol."},{"issue":"6","key":"2026081802132442800_cit49","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1021\/es303762p","article-title":"Cytotoxicity\nand oxidative damage induced by halobenzoquinones to T24 bladder cancer\ncells","volume":"47","author":"Du","year":"2013","journal-title":"Environ. Sci. 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