{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:48:12Z","timestamp":1790862492056,"version":"4.1.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2013,11,19]]},"DOI":"10.1021\/es403818e","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T13:46:26Z","timestamp":1381758386000},"page":"12753-12760","source":"Crossref","is-referenced-by-count":402,"title":["Metagenomic Profiles of Antibiotic Resistance Genes (ARGs) between Human Impacted Estuary and Deep Ocean Sediments"],"prefix":"10.1021","volume":"47","author":[{"given":"Baowei","family":"Chen","sequence":"first","affiliation":[{"name":"Department\rof Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Environmental\rBiotechnology Laboratory, The University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximei","family":"Liang","sequence":"additional","affiliation":[{"name":"South China Sea Institute of Oceanology, Chinese\rAcademy of Sciences, Guangzhou 510301, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yu","sequence":"additional","affiliation":[{"name":"Environmental\rBiotechnology Laboratory, The University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Environmental\rBiotechnology Laboratory, The University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Li","sequence":"additional","affiliation":[{"name":"Department\rof Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"issue":"5944","key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1126\/science.1176950","volume":"325","author":"Sommer M. O.","year":"2009","journal-title":"Science"},{"issue":"4","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/jac\/dkp255","volume":"64","author":"Livermore D. M.","year":"2009","journal-title":"J. Antimicrob. Chemoth."},{"issue":"5759","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1126\/science.1120800","volume":"311","author":"D\u2019Costa V. M.","year":"2006","journal-title":"Science"},{"issue":"6098","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.1220761","volume":"337","author":"Forsberg K. J.","year":"2012","journal-title":"Science"},{"issue":"5","key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.coph.2008.04.008","volume":"8","author":"Baltz R. H.","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"issue":"5872","key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1155157","volume":"320","author":"Dantas G.","year":"2008","journal-title":"Science"},{"issue":"6099","key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.1219385","volume":"337","author":"Cordero O. X.","year":"2012","journal-title":"Science"},{"issue":"3","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrmicro1614","volume":"5","author":"Wright G. D.","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"issue":"8","key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1517\/17460441.2010.497535","volume":"5","author":"Wright G. D.","year":"2010","journal-title":"Expert. Opin. Drug. Dis."},{"issue":"7365","key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10388","volume":"477","author":"D\u2019Costa V. M.","year":"2011","journal-title":"Nature"},{"issue":"4","key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"e34953","DOI":"10.1371\/journal.pone.0034953","volume":"7","author":"Bhullar K.","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1021\/ja908850p","volume":"132","author":"Toth M.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"issue":"3","key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s00248-008-9431-6","volume":"57","author":"Brown M. G.","year":"2009","journal-title":"Microbial. Ecol."},{"issue":"5910","key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/302725a0","volume":"302","author":"Hughes V. M.","year":"1983","journal-title":"Nature"},{"issue":"3","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM197001152820302","volume":"282","author":"Davis C. E.","year":"1970","journal-title":"New. Engl. J. Med."},{"issue":"2","key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"e8989","DOI":"10.1371\/journal.pone.0008989","volume":"5","author":"Thaller M. C.","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1021\/es901221x","volume":"44","author":"Knapp C. W.","year":"2010","journal-title":"Environ. Sci. Technol."},{"issue":"11","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"e48325","DOI":"10.1371\/journal.pone.0048325","volume":"7","author":"Durso L. M.","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"e48000","DOI":"10.1371\/journal.pone.0048000","volume":"7","author":"Port J. A.","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.watres.2013.02.042","volume":"47","author":"Chen B. W.","year":"2013","journal-title":"Water Res."},{"issue":"3","key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00253-008-1829-z","volume":"82","author":"Zhang X. X.","year":"2009","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"3","key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.envpol.2006.05.038","volume":"145","author":"Xu W. H.","year":"2007","journal-title":"Environ. Pollut."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.chemosphere.2013.03.044","volume":"92","author":"Liang X. M.","year":"2013","journal-title":"Chemosphere"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"D443","DOI":"10.1093\/nar\/gkn656","volume":"37","author":"Liu B.","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"18","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"10197","DOI":"10.1021\/es4017365","volume":"47","author":"Yang Y.","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"8","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/bioinformatics\/btp105","volume":"25","author":"Moura A.","year":"2009","journal-title":"Bioinformatics"},{"issue":"10","key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"e26041","DOI":"10.1371\/journal.pone.0026041","volume":"6","author":"Zhang T.","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/003335491212700103","volume":"127","author":"Landers T. F.","year":"2012","journal-title":"Public Health Rep."},{"issue":"3","key":"ref29\/cit29","first-page":"321","volume":"30","author":"Zinner S. H.","year":"2007","journal-title":"New Microbiol."},{"issue":"12","key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1128\/aem.54.12.2916-2923.1988","volume":"54","author":"Fredrickson J. K.","year":"1988","journal-title":"Appl. Environ. Microb."},{"issue":"2","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s101260000067","volume":"3","author":"Kurusu Y.","year":"2001","journal-title":"Mar. Biotechnol."},{"issue":"10","key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1021\/jo1002054","volume":"75","author":"Hughes C. C.","year":"2010","journal-title":"J. Org. Chem."},{"issue":"1","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/mr.59.1.143-169.1995","volume":"59","author":"Amann R. I.","year":"1995","journal-title":"Microbiol. Rev."},{"issue":"5","key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0022-2836(03)00662-4","volume":"330","author":"Tenson T.","year":"2003","journal-title":"J. Mol. Biol."},{"issue":"19","key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1128\/JB.183.19.5639-5644.2001","volume":"183","author":"Kobayashi N.","year":"2001","journal-title":"J. Bacteriol."},{"issue":"4","key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1365-2958.2011.07744.x","volume":"81","author":"Modali S. D.","year":"2011","journal-title":"Mol. Microbiol."},{"issue":"9","key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1128\/JB.00028-12","volume":"194","author":"Shin S. H.","year":"2012","journal-title":"J. Bacteriol."},{"issue":"2","key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2958.2010.07330.x","volume":"78","author":"Husain F.","year":"2010","journal-title":"Mol. Microbiol."},{"issue":"1","key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1128\/AAC.00715-09","volume":"54","author":"Padilla E.","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1574-6968.1996.tb07983.x","volume":"135","author":"Lacroix F. J. C.","year":"1996","journal-title":"Fems. Microbiol. Lett."},{"issue":"12","key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1073\/pnas.68.12.3223","volume":"68","author":"Stone K. J.","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"11","key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1021\/bi00735a014","volume":"12","author":"Hsuchen C. C.","year":"1973","journal-title":"Biochemistry"},{"issue":"1","key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1128\/AAC.8.1.95","volume":"8","author":"Schindler P. R.","year":"1975","journal-title":"Antimicrob. Agents Ch."},{"issue":"29","key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"30106","DOI":"10.1074\/jbc.M401701200","volume":"279","author":"El Ghachi M.","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"42","key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"13370","DOI":"10.1021\/bi048551f","volume":"43","author":"Gatzeva-Topalova P. Z.","year":"2004","journal-title":"Biochemistry"},{"issue":"6","key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.str.2005.03.018","volume":"13","author":"Gatzeva-Topalova P. Z.","year":"2005","journal-title":"Structure"},{"issue":"1","key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-1119(96)00323-X","volume":"179","author":"Silver S.","year":"1996","journal-title":"Gene"},{"issue":"4","key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s007750050053","volume":"1","author":"Rosen B. P.","year":"1996","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.biochem.73.011303.074104","volume":"73","author":"Koronakis V.","year":"2004","journal-title":"Annu. Rev. Biochem."},{"issue":"5","key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"e38208","DOI":"10.1371\/journal.pone.0038208","volume":"7","author":"Taylor D. L.","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1517\/13543784.10.8.1409","volume":"10","author":"Ryan B. M.","year":"2001","journal-title":"Exp. Opin. Invest. Drugs"},{"issue":"9","key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/ismej.2013.60","volume":"7","author":"Zhou A. F.","year":"2013","journal-title":"ISME J."},{"issue":"1","key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/01490458909377849","volume":"7","author":"Fredrickson J. K.","year":"1989","journal-title":"Geomicrobiol. J."},{"issue":"19","key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1021\/es101657s","volume":"44","author":"Storteboom H.","year":"2010","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1021\/es102473z","volume":"45","author":"Graham D. W.","year":"2011","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"ref56\/cit56","first-page":"172","volume":"43","author":"Song J. S.","year":"2005","journal-title":"J. Microbiol."},{"issue":"2","key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.drup.2004.02.003","volume":"7","author":"Hall B. G.","year":"2004","journal-title":"Drug Resist. Update"},{"issue":"21","key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"11541","DOI":"10.1021\/es302657r","volume":"46","author":"Pruden A.","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"9","key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1021\/es204665b","volume":"46","author":"Negreanu Y.","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"9","key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1073\/pnas.1222743110","volume":"110","author":"Zhu Y. G.","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"16","key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"8672","DOI":"10.1021\/es3018607","volume":"46","author":"Shah S. Q. A.","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1086\/514916","volume":"27","author":"Baquero F.","year":"1998","journal-title":"Clin. Infect. Dis."},{"issue":"2","key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1365-2796.2002.01026.x","volume":"252","author":"Normark B. H.","year":"2002","journal-title":"J. Intern. Med."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1086\/514917","volume":"27","author":"Maiden M. C. J.","year":"1998","journal-title":"Clin. Infect. Dis."},{"issue":"9","key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s000180050021","volume":"56","author":"Mazel D.","year":"1999","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11274-012-1190-3","volume":"29","author":"Pu X. Y.","year":"2013","journal-title":"World J. Microb. Biot."},{"issue":"1","key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1469-0691.2006.01492.x","volume":"13","author":"Woodford N.","year":"2007","journal-title":"Clin. Microbiol. Infec."},{"issue":"7","key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1128\/AAC.44.7.1771-1777.2000","volume":"44","author":"Martinez J. L.","year":"2000","journal-title":"Antimicrob. Agents Ch."},{"issue":"10","key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1128\/AAC.48.10.3806-3812.2004","volume":"48","author":"Doublet B.","year":"2004","journal-title":"Antimicrob. Agents Ch."},{"issue":"4","key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1096\/fj.09-144972","volume":"24","author":"Venturini C.","year":"2010","journal-title":"Faseb. J."}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/es403818e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T18:05:30Z","timestamp":1680717930000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/es403818e"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,4]]},"references-count":70,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2013,11,19]]}},"alternative-id":["10.1021\/es403818e"],"URL":"https:\/\/doi.org\/10.1021\/es403818e","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,4]]}}}