{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:28:06Z","timestamp":1789021686918,"version":"build-2803163510"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2014,6,3]]},"DOI":"10.1021\/es500750w","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T01:21:37Z","timestamp":1399598497000},"page":"6409-6418","source":"Crossref","is-referenced-by-count":82,"title":["Identifying Early Urinary Metabolic Changes with Long-Term Environmental Exposure to Cadmium by Mass-Spectrometry-Based Metabolomics"],"prefix":"10.1021","volume":"48","author":[{"given":"Yanhong","family":"Gao","sequence":"first","affiliation":[{"name":"Guangdong Provincial Center for Disease Control and Prevention, 160 Qunxian Road, Panyu, Guangzhou, Guangdong 511430, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghai","family":"Lu","sequence":"additional","affiliation":[{"name":"Saw\rSwee Hock School of Public Health, National University of Singapore (NUS), 16 Medical Drive, Singapore 117597, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaomin","family":"Huang","sequence":"additional","affiliation":[{"name":"Saw\rSwee Hock School of Public Health, National University of Singapore (NUS), 16 Medical Drive, Singapore 117597, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Gao","sequence":"additional","affiliation":[{"name":"NUS\rEnvironmental Research Institute (NERI), National University of Singapore (NUS), 5A Engineering Drive 1, Singapore 117411, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxia","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Center for Disease Control and Prevention, 160 Qunxian Road, Panyu, Guangzhou, Guangdong 511430, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongning","family":"Wu","sequence":"additional","affiliation":[{"name":"China National Center for Food Safety Risk Assessment (CFSA), 7 Panjiayuan Nanli, Beijing 100021, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Center for Disease Control and Prevention, 160 Qunxian Road, Panyu, Guangzhou, Guangdong 511430, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Center for Disease Control and Prevention, 160 Qunxian Road, Panyu, Guangzhou, Guangdong 511430, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuying","family":"Tang","sequence":"additional","affiliation":[{"name":"Jinan University, 601 Huangpu West Avenue, Tianhe, Guangzhou, Guangdong 510632, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guian","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinan University, 601 Huangpu West Avenue, Tianhe, Guangzhou, Guangdong 510632, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yang","sequence":"additional","affiliation":[{"name":"Jinan University, 601 Huangpu West Avenue, Tianhe, Guangzhou, Guangdong 510632, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Center for Disease Control and Prevention, 160 Qunxian Road, Panyu, Guangzhou, Guangdong 511430, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Chen","sequence":"additional","affiliation":[{"name":"Jinan University, 601 Huangpu West Avenue, Tianhe, Guangzhou, Guangdong 510632, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Institute of Public Health, 160 Qunxian Road, Panyu, Guangzhou, Guangdong 511430, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Institute of Public Health, 160 Qunxian Road, Panyu, Guangzhou, Guangdong 511430, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Institute of Public Health, 160 Qunxian Road, Panyu, Guangzhou, Guangdong 511430, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Center for Disease Control and Prevention, 160 Qunxian Road, Panyu, Guangzhou, Guangdong 511430, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfen","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Center for Disease Control and Prevention, 160 Qunxian Road, Panyu, Guangzhou, Guangdong 511430, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon Nam","family":"Ong","sequence":"additional","affiliation":[{"name":"Saw\rSwee Hock School of Public Health, National University of Singapore (NUS), 16 Medical Drive, Singapore 117597, Singapore"},{"name":"NUS\rEnvironmental Research Institute (NERI), National University of Singapore (NUS), 5A Engineering Drive 1, Singapore 117411, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"issue":"2","key":"ref1\/cit1","first-page":"103","volume":"27","author":"Anetor J. I.","year":"2012","journal-title":"Niger. J. Physiol. Sci."},{"issue":"5","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1023\/B:BIOM.0000045731.75602.b9","volume":"17","author":"Bernard A.","year":"2004","journal-title":"BioMetals"},{"issue":"2","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1289\/ehp.1103699","volume":"120","author":"Liang Y.","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1289\/ehp.0901234","volume":"118","author":"Satarug S.","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"9","key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1289\/ehp.1306607","volume":"121","author":"Chaumont A.","year":"2013","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00420-012-0757-5","volume":"86","author":"Ikeda M.","year":"2013","journal-title":"Int. Arch. Occup. Environ. Health"},{"issue":"10","key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1289\/ehp.11452","volume":"116","author":"Gallagher C. M.","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1465-9921-11-53","volume":"11","author":"Lin Y. S.","year":"2010","journal-title":"Respir. Res."},{"issue":"2","key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1179\/oeh.2007.13.2.202","volume":"13","author":"Huff J.","year":"2007","journal-title":"Int. J. Occup. Environ. Health"},{"issue":"10","key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"A296","DOI":"10.1289\/ehp.1307376","volume":"121","author":"Adams S. V.","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref11\/cit11","unstructured":"World Health Organization (WHO). Cadmium.International Programme on Chemical Safety: Environmental Health Criteria (EHC);WHO:Geneva, Switzerland, 1992; Vol.134."},{"issue":"4","key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/csr.105","volume":"12","author":"Frost S.","year":"2005","journal-title":"Corp. Soc. Responsib. Environ. Manage."},{"issue":"1","key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1539\/joh.44.15","volume":"44","author":"Zhang G.","year":"2002","journal-title":"J. Occup. Health"},{"key":"ref14\/cit14","first-page":"1","author":"J\u00e4rup L.","year":"1998","journal-title":"Scand. J. Work, Environ. Health"},{"issue":"8","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"e2373","DOI":"10.1371\/journal.pntd.0002373","volume":"7","author":"Cui L.","year":"2013","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"4","key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s11306-011-0364-6","volume":"8","author":"Lu Y.","year":"2012","journal-title":"Metabolomics"},{"issue":"3","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1139\/er-2013-0011","volume":"21","author":"Lankadurai B. P.","year":"2013","journal-title":"Environ. Rev."},{"issue":"1","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11306-008-0152-0","volume":"5","author":"Bundy J. G.","year":"2009","journal-title":"Metabolomics"},{"issue":"1","key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1741-7015-10-61","volume":"10","author":"Ellis J. K.","year":"2012","journal-title":"BMC Med."},{"issue":"4","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.3390\/ijerph110403661","volume":"11","author":"Suvagandha D.","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"36","key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1021\/jf402043m","volume":"61","author":"Lu Y.","year":"2013","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/mas.20316","volume":"30","author":"Xu F.","year":"2011","journal-title":"Mass Spectrom. Rev."},{"issue":"8","key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1021\/pr070183p","volume":"6","author":"Gika H. G.","year":"2007","journal-title":"J. Proteome Res."},{"issue":"4","key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1021\/ac051705s","volume":"78","author":"Wagner S.","year":"2006","journal-title":"Anal. Chem."},{"issue":"9","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1039\/c3mb70138g","volume":"9","author":"Wen T.","year":"2013","journal-title":"Mol. Biosyst."},{"key":"ref26\/cit26","volume-title":"Atlas of the Ecological Environmental Geochemistry of China","author":"Li J.","year":"1999"},{"key":"ref27\/cit27","first-page":"002","volume":"6","author":"Wang M.","year":"2006","journal-title":"Chin. J. Food Hyg."},{"issue":"3","key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s002449910050","volume":"38","author":"Paschal D.","year":"2000","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"5","key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/ki.2010.165","volume":"78","author":"Waikar S. S.","year":"2010","journal-title":"Kidney Int."},{"issue":"5","key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1373\/clinchem.2004.032292","volume":"50","author":"Miller R. C.","year":"2004","journal-title":"Clin. Chem."},{"issue":"3","key":"ref31\/cit31","first-page":"154","volume":"6","author":"Kanter M.","year":"2009","journal-title":"Eur. J. Gen. Med."},{"issue":"1","key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0895-3988(09)60014-3","volume":"22","author":"Kataranovski M.","year":"2009","journal-title":"Biomed. Environ. Sci."},{"issue":"10","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1093\/clinchem\/38.10.1933","volume":"38","author":"Perrone R. D.","year":"1992","journal-title":"Clin. Chem."},{"issue":"2","key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1124\/jpet.105.085613","volume":"314","author":"Deguchi T.","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s00216-012-6636-9","volume":"405","author":"Boelaert J.","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"issue":"2","key":"ref36\/cit36","first-page":"328","volume":"21","author":"Gargah T.","year":"2010","journal-title":"Saudi J. Kidney Dis. Transplant."},{"issue":"5","key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10534-010-9329-x","volume":"23","author":"Cuypers A.","year":"2010","journal-title":"BioMetals"},{"issue":"7","key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1289\/ehp.97105712","volume":"105","author":"Yang C.","year":"1997","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11011-006-9041-2","volume":"22","author":"Pederzolli C. D.","year":"2007","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/mas.20109","volume":"26","author":"DiMarco T.","year":"2007","journal-title":"Mass Spectrom. Rev."},{"issue":"3","key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.taap.2009.01.029","volume":"238","author":"Liu J.","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"8","key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-7847.70902","volume":"4","author":"Lobo V.","year":"2010","journal-title":"Pharmacogn. Rev."},{"issue":"2","key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/mgme.1999.2857","volume":"67","author":"Amores-S\u00e1nchez M. I.","year":"1999","journal-title":"Mol. Genet. Metab."},{"issue":"11","key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1002\/jcb.24233","volume":"113","author":"Chen G.","year":"2012","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1423-0127-17-S1-S4","volume":"17","author":"Chesney R. W.","year":"2010","journal-title":"J. Biomed. Sci."},{"issue":"3","key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1167\/iovs.02-0409","volume":"44","author":"Gukasyan H. J.","year":"2003","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"7","key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nrneph.2010.69","volume":"6","author":"Chillaron J.","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"ref48\/cit48","first-page":"148","volume":"11","author":"Wu H.","year":"2003","journal-title":"J. Food Drug Anal."},{"issue":"1","key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0304-4165(01)00198-2","volume":"1568","author":"Kang J. H.","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"ref50\/cit50","first-page":"91","volume":"102","author":"Shi X.","year":"1994","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2265.2008.03455.x","volume":"71","author":"Yi S.","year":"2009","journal-title":"Clin. Endocrinol."},{"issue":"1","key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-2458-8-72","volume":"8","author":"Menke A.","year":"2008","journal-title":"BMC Public Health"},{"issue":"3","key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1158\/1055-9965.EPI-04-0619","volume":"14","author":"Nagata C.","year":"2005","journal-title":"Cancer Epidemiol., Biomarkers Prev."},{"issue":"5","key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/153537020422900506","volume":"229","author":"Henson M. C.","year":"2004","journal-title":"Exp. Biol. Med."},{"issue":"10","key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1136\/oem.57.10.668","volume":"57","author":"J\u00e4rup L.","year":"2000","journal-title":"Occup. Environ. Med."},{"issue":"12","key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1021\/es0700303","volume":"41","author":"Bundy J. G.","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1741-7007-6-25","volume":"6","author":"Bundy J. G.","year":"2008","journal-title":"BMC Biol."},{"issue":"2","key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00125-011-2339-6","volume":"55","author":"Ng D.","year":"2012","journal-title":"Diabetologia"}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/es500750w","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T21:57:24Z","timestamp":1682200644000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/es500750w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,16]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,6,3]]}},"alternative-id":["10.1021\/es500750w"],"URL":"https:\/\/doi.org\/10.1021\/es500750w","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,16]]}}}