{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:14:07Z","timestamp":1788383647385,"version":"build-2803163510"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T00:00:00Z","timestamp":1422489600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The reactions of potassium salts of the dithiocarbamates L {where L = pyrazolyldithiocarbamate (L1), 3,5-dimethylpyrazolyldithiocarbamate (L2), or indazolyldithiocarbamate (L3)} with the gold precursors [AuCl(PPh3)], [Au2Cl2(dppe)], [Au2Cl2(dppp)], or [Au2Cl2(dpph)] lead to the new gold(I) complexes [AuL(PPh3)] (1\u20133), [Au2L2(dppe)] (4\u20136), [(Au2L2)(dppp)] (7\u20139), and [Au2(L)2(dpph)] (10\u201312) {where dppe = 1,2-bis(diphenylphosphino)ethane, dppp = 1,3-bis(diphenylphosphino)propane, and dpph = 1,6-bis(diphenylphosphino)hexane}. These gold compounds were characterized by a combination of NMR and infrared spectroscopy, microanalysis, and mass spectrometry; and in selected cases by single-crystal X-ray crystallography. Compounds 4\u20136, which have dppe ligands, are unstable in solution for prolonged periods, with 4 readily transforming to the Au18 cluster [Au18S8(dppe)6]Cl2 (4a) in dichloromethane. Compounds 1\u20133 and 7\u201312 are all active against human cervical epithelioid carcinoma (HeLa) cells, but the most active compounds are 10 and 11, with IC50 values of 0.51 \u03bcM and 0.14 \u03bcM, respectively. Compounds 10 and 11 are more selective toward HeLa cells than they are toward normal cells, with selectivities of 25.0 and 70.5, respectively. Further tests, utilizing the 60-cell-line Developmental Therapeutics Program at the National Cancer Institute (U.S.A.), showed 10 and 11 to be active against nine other types of cancers.<\/jats:p>","DOI":"10.1021\/ic4025926","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T14:57:33Z","timestamp":1391007453000},"page":"2058-2067","source":"Crossref","is-referenced-by-count":85,"title":["Phosphinogold(I)\nDithiocarbamate Complexes: Effect\nof the Nature of Phosphine Ligand on Anticancer Properties"],"prefix":"10.1021","volume":"53","author":[{"given":"Frankline K.","family":"Keter","sequence":"first","affiliation":[{"name":"University of Johannesburg , , P.O. Box 524 , ,","place":["Auckland Park, South Africa, 2006"]},{"name":"Mintek , , Private Bag X3015 , ,","place":["Randburg, South Africa, 2125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilia A.","family":"Guzei","sequence":"additional","affiliation":[{"name":"University of Johannesburg , , P.O. Box 524 , ,","place":["Auckland Park, South Africa, 2006"]},{"name":"University of Wisconsin-Madison , , 1101 University Avenue , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margo","family":"Nell","sequence":"additional","affiliation":[{"name":"University of Pretoria , , ,","place":["Pretoria, South Africa, 0002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner E. van","family":"Zyl","sequence":"additional","affiliation":[{"name":"University of Johannesburg , , P.O. Box 524 , ,","place":["Auckland Park, South Africa, 2006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Darkwa","sequence":"additional","affiliation":[{"name":"University of Johannesburg , , P.O. Box 524 , ,","place":["Auckland Park, South Africa, 2006"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"2026090216122039500_cit1","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.ccr.2009.02.026","volume":"253","author":"Bindoli","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"2026090216122039500_cit2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1040-8428(01)00216-5","volume":"42","author":"Tiekink","year":"2002","journal-title":"Crit. 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