{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:23:29Z","timestamp":1792034609488,"version":"4.4.0"},"reference-count":21,"publisher":"American Chemical Society (ACS)","issue":"52","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2003,12,1]]},"DOI":"10.1021\/ja038923s","type":"journal-article","created":{"date-parts":[[2003,12,23]],"date-time":"2003-12-23T06:07:03Z","timestamp":1072159623000},"page":"16208-16209","source":"Crossref","is-referenced-by-count":73,"title":["Kinetic Isotope Effects on the Rate-Limiting Step of Heme Oxygenase Catalysis Indicate Concerted Proton Transfer\/Heme Hydroxylation"],"prefix":"10.1021","volume":"125","author":[{"given":"Roman","family":"Davydov","sequence":"first","affiliation":[{"name":"Department of Chemistry, Northwestern University, Evanston, Illinois 60208, Institute for Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980-8577, Japan, Institute for Molecular Science and Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki 444-8585, Japan, and Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Northwestern University, Evanston, Illinois 60208, Institute for Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980-8577, Japan, Institute for Molecular Science and Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki 444-8585, Japan, and Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Northwestern University, Evanston, Illinois 60208, Institute for Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980-8577, Japan, Institute for Molecular Science and Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki 444-8585, Japan, and Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ikeda-Saito","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Northwestern University, Evanston, Illinois 60208, Institute for Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980-8577, Japan, Institute for Molecular Science and Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki 444-8585, Japan, and Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Northwestern University, Evanston, Illinois 60208, Institute for Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980-8577, Japan, Institute for Molecular Science and Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki 444-8585, Japan, and Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2003,12,6]]},"reference":[{"key":"ja038923sb00001\/ja038923sb00001_1","first-page":"407","volume":"51","author":"Ortiz de Montellano P. R.","year":"2001","journal-title":"Adv. Inorg. Chem."},{"key":"ja038923sb00002\/ja038923sb00002_1","first-page":"10657","volume":"121","author":"Davydov R. M.","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"ja038923sb00003\/ja038923sb00003_1","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1021\/ja0122391","volume":"124","author":"Davydov R.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ja038923sb00004\/ja038923sb00004_1","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1021\/ja010490a","volume":"123","author":"Fujii H.","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"ja038923sb00005\/ja038923sb00005_1","first-page":"538","volume":"330","author":"Lad L.","year":"2003","journal-title":"J. Mol. Biol."},{"key":"ja038923sb00006\/ja038923sb00006_1","first-page":"34659","volume":"278","author":"Friedman J.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ja038923sb00007\/ja038923sb00007_1","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1021\/ja003583l","volume":"123","author":"Davydov R.","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"ja038923sb00008\/ja038923sb00008_1","doi-asserted-by":"crossref","first-page":"10381","DOI":"10.1021\/bi0260637","volume":"41","author":"Davydov R.","year":"2002","journal-title":"Biochemistry"},{"key":"ja038923sb00009\/ja038923sb00009_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1021\/ar0202565","volume":"36","author":"Hoffman B. M.","year":"2003","journal-title":"Acc. Chem. Res."},{"key":"ja038923sb00010\/ja038923sb00010_1","volume":"125","author":"Davydov R.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ja038923sb00012\/ja038923sb00012_1","doi-asserted-by":"crossref","first-page":"9219","DOI":"10.1021\/bi980189f","volume":"37","author":"Vidakovic M.","year":"1998","journal-title":"Biochemistry"},{"key":"ja038923sb00013\/ja038923sb00013_1","first-page":"1306","volume":"1303","author":"Kenner G. W.","year":"1973","journal-title":"J. Tetrahedron Lett."},{"key":"ja038923sb00016\/ja038923sb00016_1","first-page":"121","volume-title":"Isotope Effects on Enzyme-Catalyzed Reactions","author":"Kirsch J.","year":"1977"},{"key":"ja038923sb00017\/ja038923sb00017_1","volume-title":"Physical Organic Chemistry","author":"Isaacs N. S.","year":"1995","edition":"2"},{"key":"ja038923sb00018\/ja038923sb00018_1","volume-title":"the aim being to slow the reaction, yet not to shut it off","author":"Optimization"},{"key":"ja038923sb00019\/ja038923sb00019_1","first-page":"284","volume-title":"Transition States of Biochemical Processes","author":"Schowen K. B.","year":"1978"},{"key":"ja038923sb00020\/ja038923sb00020_1","first-page":"99","volume-title":"Isotope Effects on Enzyme-Catalyzed Reactions","author":"Schowen R.","year":"1977"},{"key":"ja038923sb00022\/ja038923sb00022_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0162-0134(02)00477-4","volume":"91","author":"Harris D. L.","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"ja038923sb00023\/ja038923sb00023_1","first-page":"8948","volume":"120","author":"Harris D. L.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ja038923sb00024\/ja038923sb00024_1","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1021\/ja0171963","volume":"124","author":"Ogliaro F.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ja038923sb00025\/ja038923sb00025_1","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.1073\/pnas.0732000100","volume":"100","author":"Guallar V.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja038923s","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T16:54:27Z","timestamp":1632329667000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja038923s"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,1]]},"references-count":21,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2003,12,1]]}},"alternative-id":["10.1021\/ja038923s"],"URL":"https:\/\/doi.org\/10.1021\/ja038923s","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,1]]}}}