{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:11:19Z","timestamp":1778901079160,"version":"3.51.4"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2005,5,1]]},"DOI":"10.1021\/ja042641q","type":"journal-article","created":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T04:52:07Z","timestamp":1115182327000},"page":"6836-6849","source":"Crossref","is-referenced-by-count":44,"title":["Electrostatic Recognition and Induced Fit in the \u03ba-PVIIA Toxin Binding to <i>Shaker<\/i> Potassium Channel"],"prefix":"10.1021","volume":"127","author":[{"given":"Xiaoqin","family":"Huang","sequence":"first","affiliation":[{"name":"Contribution from the Institute of Molecular Biophysics and School of Computational Science, Department of Physics, Florida State University, Tallahassee, FL32306, and Department of Physics, Drexel University, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Dong","sequence":"additional","affiliation":[{"name":"Contribution from the Institute of Molecular Biophysics and School of Computational Science, Department of Physics, Florida State University, Tallahassee, FL32306, and Department of Physics, Drexel University, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan-Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Contribution from the Institute of Molecular Biophysics and School of Computational Science, Department of Physics, Florida State University, Tallahassee, FL32306, and Department of Physics, Drexel University, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2005,4,16]]},"reference":[{"key":"ja042641qb00001\/ja042641qb00001_1","first-page":"433","volume":"59","author":"Zhou H.-X.","year":"1993","journal-title":"Biophys. J."},{"key":"ja042641qb00002\/ja042641qb00002_1","first-page":"13070","volume":"118","author":"Zhou H.-X.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ja042641qb00003\/ja042641qb00003_1","doi-asserted-by":"crossref","first-page":"23277","DOI":"10.1074\/jbc.272.37.23265","volume":"272","author":"Radic Z.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ja042641qb00004\/ja042641qb00004_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/jmbi.1999.2919","volume":"291","author":"Elcock A. H.","year":"1999","journal-title":"J. Mol. Biol."},{"key":"ja042641qb00005\/ja042641qb00005_1","first-page":"486","volume":"248","author":"Schreiber G.","year":"1995","journal-title":"J. Mol. Biol."},{"key":"ja042641qb00006\/ja042641qb00006_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nsb0596-427","volume":"3","author":"Schreiber G.","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"ja042641qb00007\/ja042641qb00007_1","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1006\/jmbi.1998.1747","volume":"278","author":"Vijayakumar M.","year":"1998","journal-title":"J. Mol. Biol."},{"key":"ja042641qb00008\/ja042641qb00008_1","first-page":"433","volume":"59","author":"Zhou H.-X.","year":"2001","journal-title":"Biopolymers"},{"key":"ja042641qb00009\/ja042641qb00009_1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1006\/jmbi.2000.4404","volume":"306","author":"Gabdoulline R. F.","year":"2001","journal-title":"J. Mol. Biol."},{"key":"ja042641qb00010\/ja042641qb00010_1","first-page":"2397","volume":"106","author":"Zhou H.-X.","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ja042641qb00011\/ja042641qb00011_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0006-3495(03)74453-1","volume":"85","author":"Dong F.","year":"2003","journal-title":"Biophys. J."},{"key":"ja042641qb00012\/ja042641qb00012_1","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1074\/jbc.275.8.5478","volume":"275","author":"Osaka H.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ja042641qb00013\/ja042641qb00013_1","first-page":"23598","volume":"276","author":"Papineni R. V. L.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ja042641qb00014\/ja042641qb00014_1","first-page":"1597","volume":"5","author":"Scanlon M. J.","year":"1997","journal-title":"J. Structure"},{"key":"ja042641qb00015\/ja042641qb00015_1","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1021\/bi9730341","volume":"37","author":"Savarin P.","year":"1998","journal-title":"Biochemistry"},{"key":"ja042641qb00016\/ja042641qb00016_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1085\/jgp.114.1.141","volume":"114","author":"Garcia E.","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"ja042641qb00017\/ja042641qb00017_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1085\/jgp.114.1.125","volume":"114","author":"Terlau H.","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"ja042641qb00018\/ja042641qb00018_1","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1016\/S0006-3495(02)75641-5","volume":"82","author":"Naranjo D.","year":"2002","journal-title":"Biophys. J."},{"key":"ja042641qb00019\/ja042641qb00019_1","first-page":"209","volume":"86","author":"Koch E. D.","year":"2004","journal-title":"Biophys. J."},{"key":"ja042641qb00020\/ja042641qb00020_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0896-6273(00)80057-4","volume":"16","author":"Gross A.","year":"1996","journal-title":"Neuron"},{"key":"ja042641qb00021\/ja042641qb00021_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0896-6273(00)80030-6","volume":"16","author":"Ranganathan R.","year":"1996","journal-title":"Neuron"},{"key":"ja042641qb00022\/ja042641qb00022_1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/31978","volume":"392","author":"Kreusch A.","year":"1998","journal-title":"Nature"},{"key":"ja042641qb00023\/ja042641qb00023_1","doi-asserted-by":"crossref","first-page":"24644","DOI":"10.1074\/jbc.C900990199","volume":"275","author":"Jacobsen R. B.","year":"2000","journal-title":"J. Biol Chem."},{"key":"ja042641qb00024\/ja042641qb00024_1","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1016\/S0006-3495(03)70020-4","volume":"84","author":"Shealy R. T.","year":"2003","journal-title":"Biophys. J."},{"key":"ja042641qb00025\/ja042641qb00025_1","doi-asserted-by":"crossref","first-page":"12612","DOI":"10.1073\/pnas.2235650100","volume":"100","author":"Sokolova O.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ja042641qb00026\/ja042641qb00026_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0014-5793(04)00254-6","volume":"564","author":"Sokolova O.","year":"2004","journal-title":"FEBS Lett."},{"key":"ja042641qb00027\/ja042641qb00027_1","first-page":"38","volume":"273","author":"Shon K.-J.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ja042641qb00028\/ja042641qb00028_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s002490100134","volume":"30","author":"Ranatunga K. M.","year":"2001","journal-title":"Eur. Biophys. J."},{"key":"ja042641qb00029\/ja042641qb00029_1","first-page":"2609","volume":"83","author":"Eriksson M. A. L.","year":"2002","journal-title":"Biophys. J."},{"key":"ja042641qb00030\/ja042641qb00030_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1126\/science.7694359","volume":"262","author":"MacKinnon R.","year":"1993","journal-title":"Science"},{"key":"ja042641qb00031\/ja042641qb00031_1","doi-asserted-by":"crossref","first-page":"77615","DOI":"10.1073\/pnas.1332409100","volume":"100","author":"Sigg D.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ja042641qb00032\/ja042641qb00032_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.280.5360.69","volume":"280","author":"Doyle D. A.","year":"1998","journal-title":"Science"},{"key":"ja042641qb00033\/ja042641qb00033_1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/35079500","volume":"411","author":"Zhou M.","year":"2001","journal-title":"Nature"},{"key":"ja042641qb00034\/ja042641qb00034_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/35102009","volume":"414","author":"Zhou Y.","year":"2001","journal-title":"Nature"},{"key":"ja042641qb00035\/ja042641qb00035_1","first-page":"41","volume":"423","author":"Jiang Y.","year":"2003","journal-title":"Nature"},{"key":"ja042641qb00036\/ja042641qb00036_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1126\/science.280.5360.106","volume":"280","author":"MacKinnon R.","year":"1998","journal-title":"Science"},{"key":"ja042641qb00037\/ja042641qb00037_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.285.5424.73","volume":"285","author":"Perozo E.","year":"1999","journal-title":"Science"},{"key":"ja042641qb00038\/ja042641qb00038_1","first-page":"813","volume":"413","author":"Lu Z.","year":"2001","journal-title":"Nature"},{"key":"ja042641qb00039\/ja042641qb00039_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0014-5793(03)01104-9","volume":"555","author":"MacKinnon R.","year":"2003","journal-title":"FEBS Lett."},{"key":"ja042641qb00040\/ja042641qb00040_1","first-page":"522","volume":"417","author":"Jiang Y.","year":"2002","journal-title":"Nature"},{"key":"ja042641qb00041\/ja042641qb00041_1","first-page":"526","volume":"417","author":"Jiang Y.","year":"2002","journal-title":"Nature"},{"key":"ja042641qb00042\/ja042641qb00042_1","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1126\/science.1084993","volume":"300","author":"Kuo A.","year":"2003","journal-title":"Science"},{"key":"ja042641qb00043\/ja042641qb00043_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0165-6147(03)00080-4","volume":"24","author":"Rodriguez de la Vega R. C.","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"ja042641qb00044\/ja042641qb00044_1","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1093\/nar\/22.22.4673","volume":"22","author":"Thompson J. D.","year":"1994","journal-title":"J. Nucleic Acids Res."},{"key":"ja042641qb00045\/ja042641qb00045_1","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1073\/pnas.89.22.10915","volume":"89","author":"Henikoff S.","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ja042641qb00046\/ja042641qb00046_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jcc.540040211","volume":"4","author":"Brooks B. R.","year":"1983","journal-title":"J. Comput. Chem."},{"key":"ja042641qb00047\/ja042641qb00047_1","volume-title":"TN","author":"Northrup S. H.","year":"1999"},{"key":"ja042641qb00048\/ja042641qb00048_1","first-page":"428","volume":"318","author":"Cui M.","year":"2002","journal-title":"J. Mol. Biol."},{"key":"ja042641qb00049\/ja042641qb00049_1","first-page":"2385","volume":"83","author":"Fu W.","year":"2002","journal-title":"Biophys. J."},{"key":"ja042641qb00050\/ja042641qb00050_1","first-page":"1379","volume":"83","author":"Lin J. H.","year":"2002","journal-title":"Biophys. J."},{"key":"ja042641qb00051\/ja042641qb00051_1","volume-title":"CA","author":"Case D. A.","year":"2002"},{"key":"ja042641qb00052\/ja042641qb00052_1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1063\/1.445869","volume":"79","author":"Jorgensen W. L.","year":"1983","journal-title":"J. Chem. Phys."},{"key":"ja042641qb00053\/ja042641qb00053_1","first-page":"1921","volume":"105","author":"Neria E.","year":"1996","journal-title":"J. Chem. Phys."},{"key":"ja042641qb00054\/ja042641qb00054_1","doi-asserted-by":"crossref","first-page":"10092","DOI":"10.1063\/1.464397","volume":"98","author":"Darden T.","year":"1993","journal-title":"J. Chem. Phys."},{"key":"ja042641qb00055\/ja042641qb00055_1","first-page":"8593","volume":"103","author":"Essmann U.","year":"1995","journal-title":"J. Chem. Phys."},{"key":"ja042641qb00056\/ja042641qb00056_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.biophys.28.1.155","volume":"28","author":"Sagui C.","year":"1999","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"ja042641qb00057\/ja042641qb00057_1","doi-asserted-by":"crossref","first-page":"10927","DOI":"10.1063\/1.1324708","volume":"113","author":"Toukmaji A.","year":"2000","journal-title":"J. Chem. Phys."},{"key":"ja042641qb00058\/ja042641qb00058_1","first-page":"341","volume":"23","author":"Ryckaert J. P.","year":"1997","journal-title":"J. Comput. Phys."},{"key":"ja042641qb00059\/ja042641qb00059_1","first-page":"3690","volume":"81","author":"Berendsen H. J. C.","year":"1984","journal-title":"J. Chem. Phys."},{"key":"ja042641qb00060\/ja042641qb00060_1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1063\/1.1287333","volume":"113","author":"Morishita T.","year":"2000","journal-title":"J. Chem. Phys."},{"key":"ja042641qb00061\/ja042641qb00061_1","doi-asserted-by":"crossref","first-page":"7340","DOI":"10.1021\/jp011214l","volume":"105","author":"Vijayakumar M.","year":"2001","journal-title":"J. Phys. Chem. B"},{"key":"ja042641qb00062\/ja042641qb00062_1","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0006-3495(02)73904-0","volume":"83","author":"Dong F.","year":"2002","journal-title":"Biophys. J."},{"key":"ja042641qb00063\/ja042641qb00063_1","first-page":"2222","volume":"84","author":"Zhou H.-X.","year":"2003","journal-title":"Biophys. J."},{"key":"ja042641qb00064\/ja042641qb00064_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0010-4655(95)00043-F","volume":"91","author":"Madura J. D.","year":"1995","journal-title":"Comput. Phys. Commun."},{"key":"ja042641qb00065\/ja042641qb00065_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/35102067","volume":"414","author":"Berneche S.","year":"2001","journal-title":"Nature"},{"key":"ja042641qb00066\/ja042641qb00066_1","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1016\/S0006-3495(03)74702-X","volume":"85","author":"Domene C.","year":"2003","journal-title":"Biophys. J."},{"key":"ja042641qb00067\/ja042641qb00067_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1006\/jmbi.1994.1334","volume":"238","author":"McDonald I. K.","year":"1994","journal-title":"J. Mol. Biol."},{"key":"ja042641qb00069\/ja042641qb00069_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/prot.10115","volume":"47","author":"Halperin I.","year":"2002","journal-title":"Proteins"},{"key":"ja042641qb00070\/ja042641qb00070_1","first-page":"67","volume":"52","author":"Mendez R.","year":"2003","journal-title":"J. Proteins"},{"key":"ja042641qb00071\/ja042641qb00071_1","first-page":"91","volume":"52","author":"Chen R.","year":"2003","journal-title":"Proteins"},{"key":"ja042641qb00072\/ja042641qb00072_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s00249-001-0189-8","volume":"30","author":"Moran O.","year":"2001","journal-title":"Eur. Biophys. J."},{"key":"ja042641qb00073\/ja042641qb00073_1","first-page":"7205","volume":"126","author":"Bui J. M.","year":"2004","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja042641q","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T05:48:56Z","timestamp":1633326536000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja042641q"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,16]]},"references-count":72,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2005,5,1]]}},"alternative-id":["10.1021\/ja042641q"],"URL":"https:\/\/doi.org\/10.1021\/ja042641q","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,16]]}}}