{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:47:42Z","timestamp":1793195262046,"version":"4.5.0"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2006,3,1]]},"DOI":"10.1021\/ja056806m","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T05:41:04Z","timestamp":1141191664000},"page":"2970-2976","source":"Crossref","is-referenced-by-count":83,"title":["The Deacylation Mechanism of AmpC \u03b2-Lactamase at Ultrahigh Resolution"],"prefix":"10.1021","volume":"128","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Contribution from the Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Building Room 508D, 1700 4th Street, San Francisco, California 94143-2550, Department of Molecular Pharmacology & Biological Chemistry, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611-3008, and Dipartimento di Chimica, Universit\u00e1 degli studi di Modena e Reggio Emilia, via Campi 183, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Minasov","sequence":"additional","affiliation":[{"name":"Contribution from the Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Building Room 508D, 1700 4th Street, San Francisco, California 94143-2550, Department of Molecular Pharmacology & Biological Chemistry, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611-3008, and Dipartimento di Chimica, Universit\u00e1 degli studi di Modena e Reggio Emilia, via Campi 183, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer A.","family":"Roth","sequence":"additional","affiliation":[{"name":"Contribution from the Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Building Room 508D, 1700 4th Street, San Francisco, California 94143-2550, Department of Molecular Pharmacology & Biological Chemistry, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611-3008, and Dipartimento di Chimica, Universit\u00e1 degli studi di Modena e Reggio Emilia, via Campi 183, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Prati","sequence":"additional","affiliation":[{"name":"Contribution from the Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Building Room 508D, 1700 4th Street, San Francisco, California 94143-2550, Department of Molecular Pharmacology & Biological Chemistry, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611-3008, and Dipartimento di Chimica, Universit\u00e1 degli studi di Modena e Reggio Emilia, via Campi 183, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Shoichet","sequence":"additional","affiliation":[{"name":"Contribution from the Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Building Room 508D, 1700 4th Street, San Francisco, California 94143-2550, Department of Molecular Pharmacology & Biological Chemistry, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611-3008, and Dipartimento di Chimica, Universit\u00e1 degli studi di Modena e Reggio Emilia, via Campi 183, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2006,2,9]]},"reference":[{"key":"ja056806mb00001\/ja056806mb00001_1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1021\/cr030102i","volume":"105","author":"Fisher J. F.","year":"2005","journal-title":"Chem. Rev."},{"key":"ja056806mb00002\/ja056806mb00002_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1126\/science.8153624","volume":"264","author":"Davies J.","year":"1994","journal-title":"Science"},{"key":"ja056806mb00003\/ja056806mb00003_1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1128\/AAC.39.6.1211","volume":"39","author":"Bush K.","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"ja056806mb00004\/ja056806mb00004_1","doi-asserted-by":"crossref","first-page":"11261","DOI":"10.1073\/pnas.90.23.11257","volume":"90","author":"Lobkovsky E.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ja056806mb00005\/ja056806mb00005_1","first-page":"1970","volume":"46","author":"Vakulenko S. B.","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"ja056806mb00006\/ja056806mb00006_1","doi-asserted-by":"crossref","first-page":"10261","DOI":"10.1021\/bi9908787","volume":"38","author":"Crichlow G. V.","year":"1999","journal-title":"Biochemistry"},{"key":"ja056806mb00007\/ja056806mb00007_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/343284a0","volume":"343","author":"Oefner C.","year":"1990","journal-title":"Nature"},{"key":"ja056806mb00008\/ja056806mb00008_1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/0006-2952(94)00502-D","volume":"49","author":"Galleni M.","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ja056806mb00009\/ja056806mb00009_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2174\/0929867305666220319110127","volume":"5","author":"Maiti S. N.","year":"1998","journal-title":"Curr. Med. Chem."},{"key":"ja056806mb00010\/ja056806mb00010_1","first-page":"424","volume":"10","author":"Beadle B. M.","year":"2002","journal-title":"Structure"},{"key":"ja056806mb00011\/ja056806mb00011_1","first-page":"1538","volume":"119","author":"Curley K.","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"ja056806mb00012\/ja056806mb00012_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1432-1033.1990.tb15365.x","volume":"188","author":"Tsukamoto K.","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"ja056806mb00013\/ja056806mb00013_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1042\/bj3020001","volume":"302","author":"Monnaie D.","year":"1994","journal-title":"Biochem. J."},{"key":"ja056806mb00014\/ja056806mb00014_1","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1021\/bi00183a024","volume":"33","author":"Monnaie D.","year":"1994","journal-title":"Biochemistry"},{"key":"ja056806mb00015\/ja056806mb00015_1","doi-asserted-by":"crossref","first-page":"8586","DOI":"10.1021\/bi00194a024","volume":"33","author":"Dubus A.","year":"1994","journal-title":"Biochemistry"},{"key":"ja056806mb00016\/ja056806mb00016_1","doi-asserted-by":"crossref","first-page":"7764","DOI":"10.1021\/bi00023a023","volume":"34","author":"Dubus A.","year":"1995","journal-title":"Biochemistry"},{"key":"ja056806mb00017\/ja056806mb00017_1","first-page":"485","volume":"25","author":"Dubus A.","year":"1996","journal-title":"Proteins"},{"key":"ja056806mb00018\/ja056806mb00018_1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1042\/bj2560669","volume":"256","author":"Murphy B. P.","year":"1988","journal-title":"Biochem. J."},{"key":"ja056806mb00019\/ja056806mb00019_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0022-2836(02)00599-5","volume":"321","author":"Beadle B. M.","year":"2002","journal-title":"J. Mol. Biol."},{"key":"ja056806mb00020\/ja056806mb00020_1","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1021\/bi00188a004","volume":"33","author":"Lobkovsky E.","year":"1994","journal-title":"Biochemistry"},{"key":"ja056806mb00021\/ja056806mb00021_1","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.1021\/ja001676x","volume":"122","author":"Patera A.","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ja056806mb00022\/ja056806mb00022_1","first-page":"178","volume":"234","author":"Chen C. C.","year":"1993","journal-title":"J. Mol. Biol."},{"key":"ja056806mb00023\/ja056806mb00023_1","doi-asserted-by":"crossref","first-page":"13159","DOI":"10.1021\/bi034986b","volume":"42","author":"Nukaga M.","year":"2003","journal-title":"Biochemistry"},{"key":"ja056806mb00024\/ja056806mb00024_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/(SICI)1097-0134(20000701)40:1<23::AID-PROT40>3.0.CO;2-7","volume":"40","author":"Lamotte-Brasseur J.","year":"2000","journal-title":"Proteins"},{"key":"ja056806mb00025\/ja056806mb00025_1","first-page":"7664","volume":"126","author":"Gherman B. F.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ja056806mb00026\/ja056806mb00026_1","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.1021\/ja963708f","volume":"119","author":"Bulychev A.","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"ja056806mb00027\/ja056806mb00027_1","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0960-894X(01)00168-8","volume":"11","author":"Kato-Toma Y.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ja056806mb00028\/ja056806mb00028_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1042\/bj20021447","volume":"371","author":"Kato-Toma Y.","year":"2003","journal-title":"Biochem. J."},{"key":"ja056806mb00029\/ja056806mb00029_1","doi-asserted-by":"crossref","first-page":"9214","DOI":"10.1021\/bi0109358","volume":"40","author":"Powers R. A.","year":"2001","journal-title":"Biochemistry"},{"key":"ja056806mb00030\/ja056806mb00030_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1128\/AAC.43.3.543","volume":"43","author":"Trepanier S.","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"ja056806mb00031\/ja056806mb00031_1","first-page":"14491","volume":"42","author":"Roth T. A.","year":"2003","journal-title":"Biochemistry"},{"key":"ja056806mb00032\/ja056806mb00032_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0076-6879(97)76067-1","volume":"276","author":"Otwinowski Z.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ja056806mb00033\/ja056806mb00033_1","first-page":"343","volume":"277","author":"Sheldrick G. M.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ja056806mb00034\/ja056806mb00034_1","doi-asserted-by":"crossref","unstructured":"Merritt, E. A.Acta Crystallogr. Sect. D:\u2009 Biol. Crystallogr.1999,55, 1109\u22121117.","DOI":"10.1107\/S0907444999003789"},{"key":"ja056806mb00035\/ja056806mb00035_1","doi-asserted-by":"crossref","first-page":"5340","DOI":"10.1021\/ja0259640","volume":"124","author":"Minasov G.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ja056806mb00036\/ja056806mb00036_1","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1021\/jm020002p","volume":"45","author":"Powers R. A.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ja056806mb00037\/ja056806mb00037_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski R. A.","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"ja056806mb00038\/ja056806mb00038_1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1042\/bj2780801","volume":"278","author":"Varetto L.","year":"1991","journal-title":"Biochem. J."},{"key":"ja056806mb00039\/ja056806mb00039_1","first-page":"1192","volume":"1185","author":"Proctor P.","year":"1982","journal-title":"J. Chem. Soc., Perkin Trans. 2"},{"key":"ja056806mb00040\/ja056806mb00040_1","first-page":"3603","volume":"35","author":"Xu Y.","year":"1996","journal-title":"Biochemistry"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja056806m","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T01:03:52Z","timestamp":1678323832000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja056806m"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,9]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,3,1]]}},"alternative-id":["10.1021\/ja056806m"],"URL":"https:\/\/doi.org\/10.1021\/ja056806m","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,9]]}}}