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Soc."],"published-print":{"date-parts":[[2006,12,1]]},"DOI":"10.1021\/ja066472g","type":"journal-article","created":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T12:00:38Z","timestamp":1163160038000},"page":"15372-15373","source":"Crossref","is-referenced-by-count":76,"title":["FEP-Guided Selection of Bicyclic Heterocycles in Lead Optimization for Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase"],"prefix":"10.1021","volume":"128","author":[{"given":"Joseph T.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Domoal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2006,11,10]]},"reference":[{"key":"ja066472gb00001\/ja066472gb00001_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.bmcl.2005.10.038","volume":"16","author":"Jorgensen W. 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