{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:30:29Z","timestamp":1791405029152,"version":"4.3.3"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2008,5,1]]},"DOI":"10.1021\/ja078176p","type":"journal-article","created":{"date-parts":[[2008,4,12]],"date-time":"2008-04-12T01:00:45Z","timestamp":1207962045000},"page":"5908-5915","source":"Crossref","is-referenced-by-count":521,"title":["Gadolinium Chelate Coated Gold Nanoparticles As Contrast Agents for Both X-ray Computed Tomography and Magnetic Resonance Imaging"],"prefix":"10.1021","volume":"130","author":[{"given":"Christophe","family":"Alric","sequence":"first","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Taleb","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Le Duc","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Mandon","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Billotey","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Le Meur-Herland","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Brochard","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Vocanson","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Janier","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Perriat","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Roux","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Tillement","sequence":"additional","affiliation":[{"name":"Laboratoire de Physico-Chimie des Mat\u00e9riaux Luminescents, UMR 5620 CNRS - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, Laboratoire CREATIS \u2212 Animage, UMR 5515 CNRS - U630 INSERM - INSA de Lyon - Universit\u00e9 Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France, European Synchrotron Radiation Facility, ID 17 biomedical Beamline, Polygone Scientifique Louis N\u00e9el, 6 rue Jules Horowitz, 38000 Grenoble, France, Laboratoire Hubert Curien, UMR 5516 CNRS - Universit\u00e9 Jean Monnet, 42000..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,4,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc1566","volume":"5","author":"Ferrari M.","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0169-409X(02)00044-3","volume":"54","author":"Brigger I.","year":"2002","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/ddr.20069","volume":"67","author":"Sunderland C. J.","year":"2006","journal-title":"Drug Dev. Res."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1470-2045(06)70793-8","volume":"7","author":"Yezhelyev M. V.","year":"2006","journal-title":"Lancet Oncol."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/nbt994","volume":"22","author":"Gao X.","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/74464","volume":"18","author":"Lewin M.","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.addr.2006.09.009","volume":"58","author":"Torchilin V. P.","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1021\/ja068356j","volume":"129","author":"Bridot J.-L.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/nl051935m","volume":"6","author":"Mulder W. J. M.","year":"2006","journal-title":"Nano Lett."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1021\/bc0600463","volume":"17","author":"van Tilborg G. A. F.","year":"2006","journal-title":"Bioconjugate Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1002\/ijc.21672","volume":"118","author":"Medarova Z.","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1021\/nl0502569","volume":"5","author":"Veiseh O.","year":"2005","journal-title":"Nano Lett."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1021\/la052710u","volume":"22","author":"Bertorelle F.","year":"2006","journal-title":"Langmuir"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nmat1390","volume":"4","author":"Medintz I. L.","year":"2005","journal-title":"Nat. Mater."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1021\/cr980441p","volume":"99","author":"Yu S.-B.","year":"1999","journal-title":"Chem. Rev."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/3-540-46009-8_5","volume":"222","author":"Id\u00e9e J.-M.","year":"2002","journal-title":"Top. Curr. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/3-540-46009-8_4","volume":"222","author":"Krause W.","year":"2002","journal-title":"Top. Curr. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"S46\u2013S50","DOI":"10.1097\/00004424-199405001-00008","volume":"29","author":"McClennan B. L.","year":"1994","journal-title":"Invest. Radiol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1259\/bjr\/13169882","volume":"79","author":"Hainfeld J. F.","year":"2006","journal-title":"Brit. J. Radiol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1021\/ja071471p","volume":"129","author":"Kim D.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/smll.200600427","volume":"3","author":"Kattumuri V.","year":"2007","journal-title":"Small"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1021\/ja0464140","volume":"127","author":"Santra S.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nmat1571","volume":"5","author":"Rabin O.","year":"2006","journal-title":"Nat. Mater."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1021\/cr030698+","volume":"104","author":"Daniel M.-C.","year":"2004","journal-title":"Chem. Rev."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/smll.200700595","volume":"4","author":"Lewinski N.","year":"2008","journal-title":"Small"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1002\/adfm.200600242","volume":"16","author":"Deboutti\u00e8re P.-J.","year":"2006","journal-title":"Adv. Funct. Mater."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1039\/c39950001655","author":"Brust M.","year":"1995","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/sj.jcbfm.9600017","volume":"25","author":"Adam J.-F.","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0168-9002(99)00167-9","volume":"428","author":"Elleaume H., et al.","year":"1999","journal-title":"Nucl. Inst. Meth. Phys. Res. A"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1039\/B411231H","author":"Garcia B.","year":"2005","journal-title":"Chem. Commun."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1021\/la048082i","volume":"21","author":"Roux S.","year":"2005","journal-title":"Langmuir"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/nar\/30.7.1558","volume":"30","author":"Li Z.","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jconrel.2005.12.019","volume":"111","author":"Kobayashi H.","year":"2006","journal-title":"J. Controlled Release"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"N309\u2013N315","DOI":"10.1088\/0031-9155\/49\/18\/N03","volume":"49","author":"Hainfeld J. F.","year":"2004","journal-title":"Phys. Med. Biol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1021\/jm060515m","volume":"49","author":"Montet X.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1021\/nl050127s","volume":"5","author":"Loo C.","year":"2005","journal-title":"Nano Lett."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1021\/ja057254a","volume":"128","author":"Huang X.","year":"2006","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja078176p","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T19:42:44Z","timestamp":1633722164000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja078176p"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,12]]},"references-count":37,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2008,5,1]]}},"alternative-id":["10.1021\/ja078176p"],"URL":"https:\/\/doi.org\/10.1021\/ja078176p","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,12]]}}}