{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:27:03Z","timestamp":1791210423178,"version":"4.1.0"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2011,3,2]]},"DOI":"10.1021\/ja108846h","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T16:22:27Z","timestamp":1296836547000},"page":"2583-2591","source":"Crossref","is-referenced-by-count":267,"title":["Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates"],"prefix":"10.1021","volume":"133","author":[{"given":"Yu","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Chemistry, \u2021Departments of Biomedical Engineering and Radiology, NFCR Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Meyers","sequence":"additional","affiliation":[{"name":"Department of Chemistry, \u2021Departments of Biomedical Engineering and Radiology, NFCR Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Marie","family":"Broome","sequence":"additional","affiliation":[{"name":"Department of Chemistry, \u2021Departments of Biomedical Engineering and Radiology, NFCR Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm E.","family":"Kenney","sequence":"additional","affiliation":[{"name":"Department of Chemistry, \u2021Departments of Biomedical Engineering and Radiology, NFCR Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Basilion","sequence":"additional","affiliation":[{"name":"Department of Chemistry, \u2021Departments of Biomedical Engineering and Radiology, NFCR Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Burda","sequence":"additional","affiliation":[{"name":"Department of Chemistry, \u2021Departments of Biomedical Engineering and Radiology, NFCR Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,2,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrc1456","volume":"4","author":"Heldin C. H.","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ccr.2009.10.013","volume":"16","author":"Sugahara K. N.","year":"2009","journal-title":"Cancer Cell"},{"key":"ref3\/cit3","first-page":"5","volume":"392","author":"Langer R.","year":"1998","journal-title":"Nature"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.addr.2006.09.009","volume":"58","author":"Torchilin V. P.","year":"2006","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nnano.2007.387","volume":"2","author":"Peer D.","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1158\/1078-0432.CCR-07-1441","volume":"14","author":"Cho K. J.","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0065-2571(00)00013-3","volume":"41","author":"Maeda H.","year":"2001","journal-title":"Adv. Enzyme Regul."},{"key":"ref8\/cit8","first-page":"6387","volume":"46","author":"Matsumura Y.","year":"1986","journal-title":"Cancer Res."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0169-409X(98)00003-9","volume":"34","author":"Baban D. F.","year":"1998","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.drudis.2006.07.005","volume":"11","author":"Iyer A. K.","year":"2006","journal-title":"Drug Discov. Today"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1126\/science.1095833","volume":"303","author":"Allen T. M.","year":"2004","journal-title":"Science"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"10643","DOI":"10.1021\/ja801631c","volume":"130","author":"Cheng Y.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1021\/nl9003865","volume":"9","author":"Elbakry A.","year":"2009","journal-title":"Nano Lett."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1021\/ar7002804","volume":"41","author":"Jain P. K.","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1021\/ar9000026","volume":"42","author":"Gao J.","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.addr.2008.03.016","volume":"60","author":"Ghosh P.","year":"2008","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.addr.2008.08.003","volume":"60","author":"Chatterjee D. K.","year":"2008","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/10717540490433895","volume":"11","author":"Paciotti G. F.","year":"2004","journal-title":"Drug Deliv."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ddr.20066","volume":"67","author":"Paciotti G. F.","year":"2006","journal-title":"Drug Dev. Res."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1039\/b806051g","volume":"38","author":"Boisselier E.","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1021\/la0256230","volume":"18","author":"Hone D. C.","year":"2002","journal-title":"Langmuir"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1021\/ja808137c","volume":"131","author":"Kim C. K.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1021\/ja056726i","volume":"128","author":"Hong R.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"11653","DOI":"10.1021\/ja075181k","volume":"129","author":"Gibson J. D.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1021\/ja804947u","volume":"131","author":"Hwu J. R.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1021\/ja900591t","volume":"131","author":"Agasti S. S.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/jnci\/55.1.115","volume":"55","author":"Dougherty T. J.","year":"1975","journal-title":"J. Natl. Cancer Inst."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1040-8428(84)80016-5","volume":"2","author":"Dougherty T. J.","year":"1984","journal-title":"Crit. Rev. Oncol. Hemat."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jnci\/90.12.889","volume":"90","author":"Dougherty T. J.","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrc1894","volume":"6","author":"Castano A. P.","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref31\/cit31","first-page":"380","volume":"3","author":"Dolmans D. E. J. G. J.","year":"2003","journal-title":"Nature Rev."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1039\/b108586g","volume":"1","author":"Oleinick N. L.","year":"2002","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1011-1344(01)00207-X","volume":"63","author":"Girotti A. W.","year":"2001","journal-title":"J. Photochem. Photobiol. B: Biol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"10510","DOI":"10.1021\/ja053493m","volume":"127","author":"Hong I. S.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1011-1344(01)00267-6","volume":"66","author":"Konan Y. N.","year":"2002","journal-title":"J. Photochem. Photobiol. B:Biol."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.addr.2003.10.003","volume":"56","author":"van Nostrum C. F.","year":"2004","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.addr.2003.10.002","volume":"56","author":"Kessel D.","year":"2004","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/ja0343095","volume":"125","author":"Roy I.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0927-7765(99)00156-3","volume":"18","author":"Gref R.","year":"2000","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jconrel.2006.06.017","volume":"114","author":"Niidome T.","year":"2006","journal-title":"J. Controlled Release"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1021\/nl900031y","volume":"9","author":"Perrault S. D.","year":"2009","journal-title":"Nano Lett."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1021\/la902390d","volume":"26","author":"Cheng Y.","year":"2010","journal-title":"Langmuir"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1751-1097.1993.tb02282.x","volume":"57","author":"Oleinick N. L.","year":"1993","journal-title":"Photochem. Photobiol."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.taap.2007.01.025","volume":"224","author":"Miller J. D.","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1751-1097.2009.00542.x","volume":"85","author":"Bai L.","year":"2009","journal-title":"Photochem. Photobiol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1751-1097.1999.tb03280.x","volume":"69","author":"Colussi V. C.","year":"1999","journal-title":"Photochem. Photobiol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/nbt1340","volume":"25","author":"Choi H. S.","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1021\/ja067727t","volume":"129","author":"Duan H.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1039\/C39940000801","volume":"7","author":"Brust M.","year":"1994","journal-title":"J. Chem. Soc., Chem. Comm."},{"key":"ref50\/cit50","first-page":"5194","volume":"63","author":"Morris R. L.","year":"2003","journal-title":"Cancer Res."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/bjc.1989.38","volume":"59","author":"Kongshaug M.","year":"1989","journal-title":"Br. J. Cancer"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/1011-1344(91)80111-T","volume":"8","author":"Maziere J. C.","year":"1991","journal-title":"J. Photochem. Photobiol. B: Biol."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1011-1344(02)00241-5","volume":"66","author":"Haylett A. K.","year":"2002","journal-title":"J. Photochem. Photobiol. B: Biol."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S1357-2725(01)00092-9","volume":"34","author":"Polo L.","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0168-3659(01)00299-1","volume":"73","author":"Torchilin V. P.","year":"2001","journal-title":"J. Controlled Release"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1021\/nn800275r","volume":"2","author":"Zhang L.","year":"2008","journal-title":"ACS Nano"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.colsurfb.2008.07.004","volume":"66","author":"Sonavane G.","year":"2008","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1743-8977-4-10","volume":"4","author":"Sadauskas E.","year":"2007","journal-title":"Particle Fibre Toxicol."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"6574","DOI":"10.1016\/j.biomaterials.2010.05.009","volume":"31","author":"Lipka J.","year":"2010","journal-title":"Biomaterials"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1002\/smll.200800922","volume":"4","author":"Semmler-Behnke M.","year":"2008","journal-title":"Small"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0031-6997(24)01494-7","volume":"53","author":"Moghimi S. M.","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nnano.2006.170","volume":"2","author":"Liu Z.","year":"2006","journal-title":"Nat. Nanotechnol."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1021\/nl900872r","volume":"9","author":"Choi H. S.","year":"2009","journal-title":"Nano Lett."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja108846h","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T11:07:09Z","timestamp":1740913629000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja108846h"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,4]]},"references-count":63,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,3,2]]}},"alternative-id":["10.1021\/ja108846h"],"URL":"https:\/\/doi.org\/10.1021\/ja108846h","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,4]]}}}