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R.","year":"2001","journal-title":"Nature"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0092-8674(04)00131-X","volume":"116","author":"Liu L.","year":"2004","journal-title":"Cell"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1073\/pnas.0901043106","volume":"106","author":"Lima B.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"24354","DOI":"10.1074\/jbc.M109.019919","volume":"284","author":"Sanghani P. C.","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1126\/science.1281928","volume":"258","author":"Stamler J. S.","year":"1992","journal-title":"Science"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1172\/JCI24650","volume":"115","author":"Huang Z.","year":"2005","journal-title":"J. Clin. Invest."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"46349","DOI":"10.1074\/jbc.M307572200","volume":"278","author":"Nagababu E.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0891-5849(03)00406-4","volume":"35","author":"Kleinbongard P.","year":"2003","journal-title":"Free Radical Biol. Med."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.freeradbiomed.2006.12.029","volume":"42","author":"Nagababu E.","year":"2007","journal-title":"Free Radical Biol. Med."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0005-2728(99)00018-3","volume":"1411","author":"Zweier J. L.","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-5793(98)00430-X","volume":"427","author":"Millar T. M.","year":"1998","journal-title":"FEBS Lett."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(99)00788-7","volume":"454","author":"Kozlov A. V.","year":"1999","journal-title":"FEBS Lett."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cmet.2006.02.011","volume":"3","author":"Castello P. R.","year":"2006","journal-title":"Cell Metab."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/01.ATV.0000161048.72004.c2","volume":"25","author":"Lundberg J. O.","year":"2005","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm954","volume":"9","author":"Cosby K.","year":"2003","journal-title":"Nat. Med."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"H2026","DOI":"10.1152\/ajpheart.00407.2006","volume":"291","author":"Gladwin M. 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