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W.","year":"1988","journal-title":"Biochemistry"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3233(08)60241-7","volume":"24","author":"Tanford C.","year":"1970","journal-title":"Adv. Protein Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1021\/bi00761a029","volume":"11","author":"Tanford C.","year":"1972","journal-title":"Biochemistry"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1006\/jmbi.1993.1294","volume":"231","author":"Yang A. S.","year":"1993","journal-title":"J. Mol. Biol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1006\/jmbi.1994.1301","volume":"238","author":"Antosiewicz J.","year":"1994","journal-title":"J. Mol. Biol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1021\/bi002740q","volume":"40","author":"Onufriev A.","year":"2001","journal-title":"Biochemistry"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1006\/jmbi.2001.4726","volume":"309","author":"Whitten S. T.","year":"2001","journal-title":"J. Mol. Biol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1021\/bi060706r","volume":"45","author":"Khandogin J.","year":"2006","journal-title":"Biochemistry"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1016\/S0006-3495(02)75670-1","volume":"82","author":"Fitch C. A.","year":"2002","journal-title":"Biophys. J."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/prot.20128","volume":"56","author":"Lee M. S.","year":"2004","journal-title":"Proteins: Struct., Funct., Bioinf."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"L47","DOI":"10.1016\/j.bpj.2011.03.051","volume":"100","author":"Piana S.","year":"2011","journal-title":"Biophys. J."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"13403","DOI":"10.1073\/pnas.0802113105","volume":"105","author":"O\u2019Brien E. P.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1073\/pnas.97.6.2544","volume":"97","author":"Klimov D. K.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"15065","DOI":"10.1073\/pnas.0507053102","volume":"102","author":"Auton M.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. 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E.","year":"1993","journal-title":"Biochemistry"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1021\/bi9630927","volume":"36","author":"Khare D.","year":"1997","journal-title":"Biochemistry"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1529\/biophysj.106.088682","volume":"92","author":"Lindman S.","year":"2007","journal-title":"Biophys. J."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1529\/biophysj.104.042754","volume":"87","author":"Chyan C. L.","year":"2004","journal-title":"Biophys. J."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/jcc.540130812","volume":"13","author":"Kumar S.","year":"1992","journal-title":"J. Comput. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1006\/jmbi.1995.0670","volume":"254","author":"Tan Y. J.","year":"1995","journal-title":"J. Mol. Biol."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.bb.12.060183.001151","volume":"12","author":"Go N.","year":"1983","journal-title":"Annu. Rev. Biophys. Bioeng."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/(SICI)1097-0134(19990101)34:1<49::AID-PROT5>3.0.CO;2-L","volume":"34","author":"Miyazawa S.","year":"1999","journal-title":"Proteins: Struct., Funct., Genet."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","volume":"23","author":"Ryckaert J. P.","year":"1977","journal-title":"J. Comput. Phys."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1021\/bi00375a036","volume":"26","author":"McPhalen C. A.","year":"1987","journal-title":"Biochemistry"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1126\/science.1871600","volume":"253","author":"Gronenborn A. M.","year":"1991","journal-title":"Science"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1063\/1.1308516","volume":"113","author":"Sugita Y.","year":"2000","journal-title":"J. Chem. Phys."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"045103","DOI":"10.1063\/1.2822272","volume":"128","author":"Kouza M.","year":"2008","journal-title":"J. Chem. Phys."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1359-0278(97)00002-3","volume":"2","author":"Veitshans T.","year":"1997","journal-title":"Folding Des."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"Brooks B. R.","year":"1983","journal-title":"J. Comput. Chem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"6648","DOI":"10.1021\/jp0101561","volume":"105","author":"Klimov D. K.","year":"2001","journal-title":"J. Phys. Chem. B"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1021\/bi00839a052","volume":"8","author":"Aune K. C.","year":"1969","journal-title":"Biochemistry"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"9556","DOI":"10.1021\/j100176a093","volume":"95","author":"Bashford D.","year":"1991","journal-title":"J. Phys. Chem."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1073\/pnas.96.11.6166","volume":"96","author":"Klimov D. K.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"7254","DOI":"10.1073\/pnas.97.13.7254","volume":"97","author":"Klimov D. K.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1073\/pnas.0909854107","volume":"107","author":"Gebhardt J. C. M.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. 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J."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jmb.2005.09.070","volume":"354","author":"Schlierf M.","year":"2005","journal-title":"J. Mol. Biol."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"138102","DOI":"10.1103\/PhysRevLett.106.138102","volume":"106","author":"Morrison G.","year":"2011","journal-title":"Phys. Rev. Lett."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1006\/jmbi.1999.3305","volume":"294","author":"Elcock A. H.","year":"1999","journal-title":"J. Mol. Biol."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"124903","DOI":"10.1063\/1.3082151","volume":"130","author":"O\u2019Brien E. P.","year":"2009","journal-title":"J. Chem. 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