{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:17:46Z","timestamp":1791325066901,"version":"4.3.1"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2012,1,25]]},"DOI":"10.1021\/ja210335f","type":"journal-article","created":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T10:45:28Z","timestamp":1324464328000},"page":"1847-1852","source":"Crossref","is-referenced-by-count":154,"title":["Polymeric Dibromomaleimides As Extremely Efficient Disulfide Bridging Bioconjugation and Pegylation Agents"],"prefix":"10.1021","volume":"134","author":[{"given":"Mathew W.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Strickland","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix F.","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University College London, London WC1H 0AJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Caddick","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University College London, London WC1H 0AJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James. R.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University College London, London WC1H 0AJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew I.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Haddleton","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2012,1,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1126\/science.1145951","volume":"317","author":"Kiick K. L.","year":"2007","journal-title":"Science"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/ma801782q","volume":"42","author":"Liu S.","year":"2009","journal-title":"Macromolecules"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0045-2068(91)90029-O","volume":"19","author":"Wirth P.","year":"1991","journal-title":"Bioorg. Chem."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1023\/A:1016042220817","volume":"13","author":"Kinstler O. B.","year":"1996","journal-title":"Pharm. Res."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0169-409X(03)00108-X","volume":"55","author":"Caliceti P.","year":"2003","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1517\/17425247.5.4.371","volume":"5","author":"Ryan S. M.","year":"2008","journal-title":"Expert Opin. Drug Del."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1039\/c1py00034a","volume":"2","author":"Alconcel S. N. S.","year":"2011","journal-title":"Polym. Chem"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1039\/c1py00039j","volume":"2","author":"Bulmus V.","year":"2011","journal-title":"Polym. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1039\/b9py00363k","volume":"1","author":"Le Droumaguet B.","year":"2010","journal-title":"Polym. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1039\/b9py00362b","volume":"1","author":"Velonia K.","year":"2010","journal-title":"Polym. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1039\/C0PY00210K","volume":"2","author":"Magnusson J. P.","year":"2011","journal-title":"Polym. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1039\/c1py00038a","volume":"2","author":"Smith D.","year":"2011","journal-title":"Polym. Chem"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.progpolymsci.2007.07.005","volume":"33","author":"Lutz J.-F.","year":"2008","journal-title":"Prog. Polym. Sci."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/bip.21333","volume":"94","author":"Krishna O. D.","year":"2010","journal-title":"Pept. Sci."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.addr.2010.05.002","volume":"62","author":"Top A.","year":"2010","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1039\/B807871H","volume":"39","author":"Canalle L. A.","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1002\/anie.200902672","volume":"49","author":"Knop K.","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1039\/b920570p","volume":"46","author":"Joralemon M. J.","year":"2010","journal-title":"Chem. Commun."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/marc.200700112","volume":"28","author":"Nicolas J.","year":"2007","journal-title":"Macromol. Rapid Commun."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1039\/B407712A","author":"Lecolley F.","year":"2004","journal-title":"Chem. Commun."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1021\/bm8006715","volume":"9","author":"Samanta D.","year":"2008","journal-title":"Biomacromolecules"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1021\/bm1005036","volume":"11","author":"Zarafshani Z.","year":"2010","journal-title":"Biomacromolecules"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1021\/ja0430999","volume":"127","author":"Mantovani G.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"15156","DOI":"10.1021\/ja072999x","volume":"129","author":"Geng J.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1021\/bc900397s","volume":"21","author":"Da Pieve C.","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1039\/b9py00369j","volume":"1","author":"Heredia K. L.","year":"2010","journal-title":"Polym. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1039\/c0py00025f","volume":"1","author":"Li M.","year":"2010","journal-title":"Polym. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"15372","DOI":"10.1021\/ja045063m","volume":"126","author":"Bontempo D.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1039\/b804812f","author":"Heredia K. L.","year":"2008","journal-title":"Chem. Commun."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1002\/anie.200604922","volume":"46","author":"Liu J.","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1039\/b906865a","author":"Jones M. W.","year":"2009","journal-title":"Chem. Commun."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1039\/C0PY00329H","volume":"2","author":"Jones M. W.","year":"2011","journal-title":"Polym. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2165\/00063030-200822050-00005","volume":"22","author":"Bourne T.","year":"2008","journal-title":"BioDrugs"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1002\/jps.21170","volume":"97","author":"Lu Y.","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nchembio786","volume":"2","author":"Shaunak S.","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1021\/bc0601471","volume":"18","author":"Balan S.","year":"2006","journal-title":"Bioconjugate Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1021\/bc0601471","volume":"18","author":"Balan S.","year":"2007","journal-title":"Bioconjugate Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"6583","DOI":"10.1039\/b915136b","author":"Tedaldi L. M.","year":"2009","journal-title":"Chem. Commun."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1021\/ja908610s","volume":"132","author":"Smith M. E. B.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1021\/bc1004685","volume":"22","author":"Schumacher F. F.","year":"2011","journal-title":"Bioconjugate Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1021\/ma00109a056","volume":"28","author":"Kato M.","year":"1995","journal-title":"Macromolecules"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.1021\/ja00125a035","volume":"117","author":"Wang J. S.","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1021\/ma9804951","volume":"31","author":"Chiefari J.","year":"1998","journal-title":"Macromolecules"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1021\/cr990119u","volume":"101","author":"Hawker C. J.","year":"2001","journal-title":"Chem. Rev."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1517\/14712598.2010.526104","volume":"10","author":"Henriksen K.","year":"2010","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1021\/jo00121a070","volume":"60","author":"Walker M. A.","year":"1995","journal-title":"J. Org. Chem."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1021\/ma034542n","volume":"37","author":"Deng G. H.","year":"2004","journal-title":"Macromolecules"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/marc.201000664","volume":"32","author":"Lutz J.-F.","year":"2011","journal-title":"Macromol. Rapid Commun."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1021\/ma702161q","volume":"41","author":"Tolstyka Z. P.","year":"2008","journal-title":"Macromolecules"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/anie.200801951","volume":"48","author":"Gauthier M. A.","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1039\/B500558B","author":"Mantovani G.","year":"2005","journal-title":"Chem. Commun."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1021\/ma0517042","volume":"39","author":"Lutz J.-F.","year":"2006","journal-title":"Macromolecules"},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"13046","DOI":"10.1021\/ja065324n","volume":"128","author":"Lutz J.-F.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1039\/C0PY00229A","volume":"2","author":"Lavigueur C.","year":"2011","journal-title":"Polym. Chem"},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1021\/ma1005759","volume":"43","author":"Roth P. J.","year":"2010","journal-title":"Macromolecules"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1039\/C1CC11114K","volume":"47","author":"Ryan C. P.","year":"2011","journal-title":"Chem. Commun."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja210335f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T18:26:57Z","timestamp":1680546417000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja210335f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,13]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,1,25]]}},"alternative-id":["10.1021\/ja210335f"],"URL":"https:\/\/doi.org\/10.1021\/ja210335f","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,13]]}}}