{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:43:03Z","timestamp":1790394183029,"version":"4.1.0"},"reference-count":75,"publisher":"American Chemical Society (ACS)","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2012,11,7]]},"DOI":"10.1021\/ja304460j","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T12:07:57Z","timestamp":1349266077000},"page":"18275-18285","source":"Crossref","is-referenced-by-count":93,"title":["The Basis for Carbapenem Hydrolysis by Class A \u03b2-Lactamases: A Combined Investigation using Crystallography and Simulations"],"prefix":"10.1021","volume":"134","author":[{"given":"F\u00e1tima","family":"Fonseca","sequence":"first","affiliation":[{"name":"School of Cellular and Molecular\rMedicine, University of Bristol Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom"},{"name":"CESAM & Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa I.","family":"Chudyk","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc W.","family":"van der Kamp","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Correia","sequence":"additional","affiliation":[{"name":"CESAM & Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J.","family":"Mulholland","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Spencer","sequence":"additional","affiliation":[{"name":"School of Cellular and Molecular\rMedicine, University of Bristol Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1517\/14656566.9.1.23","volume":"9","author":"Nicolau D. P.","year":"2008","journal-title":"Expert Opinion on Pharmacotherapy"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1128\/AAC.00296-11","volume":"55","author":"Papp-Wallace K. M.","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ijantimicag.2008.07.023","volume":"33","author":"Masterton R. G.","year":"2009","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1021\/cr030102i","volume":"105","author":"Fisher J. F.","year":"2005","journal-title":"Chem. Rev."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijmm.2010.04.005","volume":"300","author":"Pfeifer Y.","year":"2010","journal-title":"Int. J. Med. Microbiol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0924-8579(10)70004-2","volume":"36","author":"Walsh T. R.","year":"2010","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1098\/rstb.1980.0049","volume":"289","author":"Ambler R. P.","year":"1980","journal-title":"Philos. Trans. R. Soc. London, Ser. B: Biol. Sci."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1586\/eri.11.28","volume":"9","author":"Patel G.","year":"2011","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1128\/AAC.40.9.2080","volume":"40","author":"Rasmussen B. A.","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1073\/pnas.91.16.7693","volume":"91","author":"Naas T.","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref11\/cit11","first-page":"29","volume":"143","author":"Mariotte-Boyer S.","year":"1996","journal-title":"FEMS Microbiol. Lett."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1128\/AAC.38.6.1262","volume":"38","author":"Naas T.","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1128\/AAC.45.4.1151-1161.2001","volume":"45","author":"Yigit H.","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1128\/AAC.48.6.2321-2324.2004","volume":"48","author":"Henriques I.","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.diagmicrobio.2007.02.013","volume":"58","author":"Bae I. K.","year":"2007","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1128\/AAC.00773-10","volume":"55","author":"Bonnin R. A.","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1128\/AAC.00771-10","volume":"54","author":"Kotsakis S. D.","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1128\/AAC.45.9.2598-2603.2001","volume":"45","author":"Poirel L.","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref19\/cit19","first-page":"209","volume":"234","author":"Vourli S.","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1128\/AAC.48.8.2905-2910.2004","volume":"48","author":"Wachino J.","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1473-3099(09)70054-4","volume":"9","author":"Nordmann P.","year":"2009","journal-title":"Lancet Infect. Dis."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.coph.2007.08.003","volume":"7","author":"Perez F.","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1128\/AAC.00320-06","volume":"50","author":"Wang F.","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"12656","DOI":"10.1021\/ja7111146","volume":"130","author":"Nukaga M.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"9748","DOI":"10.1021\/ja9818001","volume":"120","author":"Maveyraud L.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1021\/ja00030a070","volume":"114","author":"Zafaralla G.","year":"1992","journal-title":"J. Am. Chem. Soc."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1128\/AAC.00089-11","volume":"55","author":"Bethel C. R.","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"11830","DOI":"10.1021\/bi800833u","volume":"47","author":"Kalp M.","year":"2008","journal-title":"Biochemistry"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"26714","DOI":"10.1074\/jbc.273.41.26714","volume":"273","author":"Swaren P.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"5732","DOI":"10.1021\/bi700300u","volume":"46","author":"Ke W.","year":"2007","journal-title":"Biochemistry"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1107\/S0907444901019606","volume":"58","author":"Sougakoff W.","year":"2002","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1128\/AAC.00163-08","volume":"52","author":"Petrella S.","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"29509","DOI":"10.1074\/jbc.M109.011262","volume":"284","author":"Frase H.","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1128\/AAC.47.3.1062-1067.2003","volume":"47","author":"Majiduddin F. K.","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1128\/AAC.49.8.3421-3427.2005","volume":"49","author":"Majiduddin F. K.","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1128\/AAC.00197-10","volume":"54","author":"Papp-Wallace K. M.","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/pro.454","volume":"19","author":"Papp-Wallace K. M.","year":"2010","journal-title":"Protein Sci."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF01967080","volume":"11","author":"Pfyffer G. E.","year":"1992","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1128\/AAC.00491-07","volume":"51","author":"Fonseca F.","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1128\/AAC.47.7.2330-2333.2003","volume":"47","author":"Saavedra M. J.","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1128\/AAC.00429-11","volume":"55","author":"Fonseca F.","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jmb.2011.06.043","volume":"411","author":"Fonseca F.","year":"2011","journal-title":"J. Mol. Biol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1128\/AAC.00693-09","volume":"54","author":"Papp-Wallace K. M.","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1128\/AAC.47.12.3881-3889.2003","volume":"47","author":"Yigit H.","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/359700a0","volume":"359","author":"Strynadka N. C.","year":"1992","journal-title":"Nature"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1016\/S0021-9258(18)49972-3","volume":"266","author":"Adachi H.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1039\/B512969A","volume":"4","author":"Hermann J. C.","year":"2006","journal-title":"Org. Biomol. Chem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski Z.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ref49\/cit49","first-page":"27","volume":"26","author":"Leslie A. G. W.","year":"1992","journal-title":"Joint CCP4 + ESF-EAMCB Newsletter on Protein Crystallography"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1107\/S0907444905036693","volume":"62","author":"Evans P. R.","year":"2005","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"McCoy A. J.","year":"2007","journal-title":"J. Appl. Crystallogr."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","volume":"66","author":"Emsley P.","year":"2010","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","volume":"53","author":"Murshudov G. N.","year":"1997","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","volume":"64","author":"Sheldrick G. M.","year":"2008","journal-title":"Acta Crystallogr., Sect. A"},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","volume":"66","author":"Chen V. B.","year":"2010","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski R. A.","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"ref57\/cit57","volume-title":"AMBER 11","author":"Case D. A.","year":"2010"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/prot.21123","volume":"65","author":"Hornak V.","year":"2006","journal-title":"Proteins"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","volume":"25","author":"Wang J.","year":"2004","journal-title":"J. Comput. Chem."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"5660","DOI":"10.1128\/AAC.00245-11","volume":"55","author":"Leyssene D.","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0969-2126(02)00725-6","volume":"10","author":"Beadle B. M.","year":"2002","journal-title":"Structure"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"46601","DOI":"10.1074\/jbc.M207884200","volume":"277","author":"Shimamura T.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"9685","DOI":"10.1021\/bi1015088","volume":"49","author":"Tremblay L. W.","year":"2010","journal-title":"Biochemistry"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1021\/ja044210d","volume":"127","author":"Hermann J. C.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"9590","DOI":"10.1021\/ja034434g","volume":"125","author":"Hermann J. C.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/prot.10058","volume":"47","author":"Wang X.","year":"2002","journal-title":"Proteins"},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1126\/science.1167498","volume":"323","author":"Hugonnet J. E.","year":"2009","journal-title":"Science"},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1021\/bi100232q","volume":"49","author":"Tremblay L. W.","year":"2010","journal-title":"Biochemistry"},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1107\/S0907444904026460","volume":"60","author":"Krissinel E.","year":"2004","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gkl282","volume":"34","author":"Dundas J.","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1107\/S0907444905014356","volume":"61","author":"Stec B.","year":"2005","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0022-2836(03)00210-9","volume":"328","author":"Nukaga M.","year":"2003","journal-title":"J. Mol. Biol."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.1021\/ja0712064","volume":"129","author":"Chen Y.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1021\/bi015789k","volume":"41","author":"Fonze E.","year":"2002","journal-title":"Biochemistry"},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.1021\/ja9817996","volume":"120","author":"Mourey L.","year":"1998","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja304460j","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T06:28:43Z","timestamp":1680503323000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja304460j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,29]]},"references-count":75,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2012,11,7]]}},"alternative-id":["10.1021\/ja304460j"],"URL":"https:\/\/doi.org\/10.1021\/ja304460j","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,29]]}}}