{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:38:11Z","timestamp":1790404691955,"version":"4.1.0"},"reference-count":66,"publisher":"American Chemical Society (ACS)","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2013,7,3]]},"DOI":"10.1021\/ja4041412","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T13:50:25Z","timestamp":1370958625000},"page":"9885-9897","source":"Crossref","is-referenced-by-count":70,"title":["Drug-Induced Conformational and Dynamical Changes of the S31N Mutant of the Influenza M2 Proton Channel Investigated by Solid-State NMR"],"prefix":"10.1021","volume":"135","author":[{"given":"Jonathan K.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States"},{"name":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco,\rCalifornia 94158-9001, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tietze","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States"},{"name":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco,\rCalifornia 94158-9001, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States"},{"name":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco,\rCalifornia 94158-9001, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States"},{"name":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco,\rCalifornia 94158-9001, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"DeGrado","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States"},{"name":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco,\rCalifornia 94158-9001, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States"},{"name":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco,\rCalifornia 94158-9001, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"ref1\/cit1","unstructured":"Lamb, R. A.; Holsinger, K. J.; Pinto, L. H.InCellular Receptors of Animal Viruses;Wemmer, E., Ed.Cold Spring Harbor Lab Press:Plainview, NY, 1994; pp303\u2013321."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"8997","DOI":"10.1074\/jbc.R500020200","volume":"281","author":"Pinto L. H.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1002\/j.1460-2075.1990.tb07555.x","volume":"9","author":"Sugrue R. J.","year":"1990","journal-title":"EMBO J."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0006-3495(95)80003-2","volume":"69","author":"Wang C.","year":"1995","journal-title":"Biophys. J."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/pro.2158","volume":"21","author":"Hong M.","year":"2012","journal-title":"Protein Sci."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1126\/science.1191714","volume":"330","author":"Hu F.","year":"2010","journal-title":"Science"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1021\/ja307453v","volume":"134","author":"Hong M.","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1021\/ja2081185","volume":"134","author":"Hu F.","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1128\/JVI.75.8.3647-3656.2001","volume":"75","author":"Lin T. I.","year":"2001","journal-title":"J. Virol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"6865","DOI":"10.1073\/pnas.0601944103","volume":"103","author":"Hu J.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"15075","DOI":"10.1073\/pnas.1007071107","volume":"107","author":"Acharya A.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"39880","DOI":"10.1074\/jbc.M206582200","volume":"277","author":"Tang Y.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.1021\/bi0028441","volume":"40","author":"Okada A.","year":"2001","journal-title":"Biochemistry"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.1191750","volume":"330","author":"Sharma M.","year":"2010","journal-title":"Science"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.bpj.2013.02.054","volume":"104","author":"Williams J. K.","year":"2013","journal-title":"Biophys. J."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1002\/j.1460-2075.1985.tb04038.x","volume":"4","author":"Hay A. J.","year":"1985","journal-title":"EMBO J."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature06528","volume":"451","author":"Stouffer A. L.","year":"2008","journal-title":"Nature"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nature08722","volume":"463","author":"Cady S. D.","year":"2010","journal-title":"Nature"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1021\/ja102581n","volume":"133","author":"Cady S. D.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1021\/ja9096219","volume":"132","author":"Luo W.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1529\/biophysj.106.102103","volume":"93","author":"Hu J.","year":"2007","journal-title":"Biophys. J."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1001\/jama.295.8.joc60020","volume":"295","author":"Bright R. A.","year":"2006","journal-title":"JAMA"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.antiviral.2006.10.004","volume":"73","author":"Hurt A. C.","year":"2007","journal-title":"Antiviral Res."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3851\/IMP1538","volume":"15","author":"Zaraket H.","year":"2010","journal-title":"Antiviral Ther."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/molbev\/msm103","volume":"24","author":"Simonsen L.","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"7379","DOI":"10.1073\/pnas.0902548106","volume":"106","author":"Pielak R. M.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"7215","DOI":"10.1021\/ja3003606","volume":"134","author":"Andreas L. B.","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1021\/bi901799k","volume":"49","author":"Balannik V.","year":"2010","journal-title":"Biochemistry"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1073\/pnas.1216526110","volume":"110","author":"Wang J.","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1128\/jvi.67.9.5585-5594.1993","volume":"67","author":"Wang C.","year":"1993","journal-title":"J. Virol."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1063\/1.475661","volume":"108","author":"Hohwy M.","year":"1998","journal-title":"J. Chem. Phys."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1021\/ja980775w","volume":"120","author":"Hong M.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0009-2614(88)85051-6","volume":"146","author":"Raleigh D. P.","year":"1988","journal-title":"Chem. Phys. Lett."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1021\/bi900080d","volume":"48","author":"Su Y.","year":"2009","journal-title":"Biochemistry"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"36305","DOI":"10.1074\/jbc.M112.406371","volume":"287","author":"Chung K. Y.","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1021\/ja003266e","volume":"123","author":"Jaroniec C. P.","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00197809","volume":"6","author":"Delaglio F.","year":"1995","journal-title":"J. Biomol. NMR"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1023\/A:1008290631575","volume":"12","author":"Foster M. P.","year":"1998","journal-title":"J. Biomol. NMR"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.jmb.2008.11.022","volume":"385","author":"Cady S. D.","year":"2009","journal-title":"J. Mol. Biol."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbamem.2011.07.040","volume":"1818","author":"Gustavsson M.","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1021\/ja909752r","volume":"132","author":"Shenkarev Z. O.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1021\/ja00369a007","volume":"104","author":"Munowitz M.","year":"1982","journal-title":"J. Am. Chem. Soc."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1021\/ja108943n","volume":"133","author":"Li S.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1021\/ja011638t","volume":"124","author":"Henry B.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.1002\/mrc.951","volume":"39","author":"Bachovchin W. W.","year":"2001","journal-title":"Magn. Reson. Chem."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.1073\/pnas.1102373108","volume":"108","author":"Vila J. A.","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bbamem.2010.09.014","volume":"1808","author":"Hu F.","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1529\/biophysj.106.090183","volume":"92","author":"Hu J.","year":"2007","journal-title":"Biophys. J."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.tibs.2010.07.005","volume":"36","author":"Cross T. A.","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1016\/j.bbamem.2007.08.025","volume":"1768","author":"Li C.","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"052319","DOI":"10.1063\/1.2829984","volume":"128","author":"Bodner M. L.","year":"2008","journal-title":"J. Chem. Phys."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jmb.2012.11.027","volume":"425","author":"Yao H.","year":"2013","journal-title":"J. Mol. Biol."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jmb.2012.02.010","volume":"418","author":"Lai A. L.","year":"2012","journal-title":"J. Mol. Biol."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jmb.2008.06.007","volume":"381","author":"Su Y.","year":"2008","journal-title":"J. Mol. Biol."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/ja806306e","volume":"131","author":"Ader C.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"15179","DOI":"10.1074\/jbc.M608264200","volume":"282","author":"Takeuchi K.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jmb.2010.06.031","volume":"401","author":"Bhate M. P.","year":"2010","journal-title":"J. Mol. Biol."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"9618","DOI":"10.1073\/pnas.0402324101","volume":"101","author":"Hwang P. M.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1073\/pnas.0711500105","volume":"105","author":"Cady S. D.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.str.2008.04.011","author":"Stouffer A. L.","year":"2008","journal-title":"Structure"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.cell.2010.08.029","volume":"142","author":"Rossman J. S.","year":"2010","journal-title":"Cell"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.virol.2010.12.003","volume":"411","author":"Rossman J. S.","year":"2011","journal-title":"Virology"},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1002\/mrc.957","volume":"39","author":"Song X. J.","year":"2001","journal-title":"Magn. Reson. Chem."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2725(00)76003-X","volume":"76","author":"Elguero J.","year":"2000","journal-title":"Adv. Heterocycl. Chem."},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0065-2725(00)76005-3","volume":"76","author":"Minkin V. I.","year":"2000","journal-title":"Adv. Heterocycl. Chem."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"11572","DOI":"10.1021\/ja202051n","volume":"133","author":"Cady S. D.","year":"2011","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja4041412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T05:40:58Z","timestamp":1680759658000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja4041412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,21]]},"references-count":66,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2013,7,3]]}},"alternative-id":["10.1021\/ja4041412"],"URL":"https:\/\/doi.org\/10.1021\/ja4041412","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,21]]}}}