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Biol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1074\/jbc.C111.328575","volume":"287","author":"Zheng X.","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1021\/bi201520b","volume":"51","author":"Gessel M. M.","year":"2012","journal-title":"Biochemistry"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1073\/pnas.0511256103","volume":"103","author":"Bodner R. A.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"16958","DOI":"10.1021\/ja206279b","volume":"133","author":"Sinha S.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"24228","DOI":"10.1074\/jbc.M110.133108","volume":"285","author":"Ladiwala A. R.","year":"2010","journal-title":"J. Biol. 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Res."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"7951","DOI":"10.1073\/pnas.90.17.7951","volume":"90","author":"Loo D. T.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1046\/j.1471-4159.1995.64010253.x","volume":"64","author":"Pike C. J.","year":"1995","journal-title":"Journal of Neurochemistrv"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11064-008-9776-8","volume":"34","author":"Frozza R. L.","year":"2009","journal-title":"Neurochem. Res."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"11532","DOI":"10.1021\/bi060601o","volume":"45","author":"Zameer A.","year":"2006","journal-title":"Biochemistry"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1039\/c000755m","volume":"12","author":"Wei G.","year":"2010","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1529\/biophysj.105.079186","volume":"91","author":"Wei G.","year":"2006","journal-title":"Biophys. J."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"15288","DOI":"10.1021\/jp1065264","volume":"114","author":"Kittner M.","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.bpj.2012.06.027","volume":"103","author":"Larini L.","year":"2012","journal-title":"Biophys. J."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1460-9568.2005.04532.x","volume":"23","author":"Bastianetto S.","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijms.2006.07.021","volume":"261","author":"Pringle S. D.","year":"2007","journal-title":"Int. J. 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