{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:35:25Z","timestamp":1791491725021,"version":"4.3.4"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"45","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2013,11,13]]},"DOI":"10.1021\/ja406995j","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T08:39:48Z","timestamp":1381739988000},"page":"16968-16976","source":"Crossref","is-referenced-by-count":92,"title":["Protein Dielectric Constants Determined from NMR Chemical Shift Perturbations"],"prefix":"10.1021","volume":"135","author":[{"given":"Predrag","family":"Kukic","sequence":"first","affiliation":[{"name":"School\rof Biomolecular and Biomedical Science, Centre for Synthesis and Chemical\rBiology, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Farrell","sequence":"additional","affiliation":[{"name":"School\rof Biomolecular and Biomedical Science, Centre for Synthesis and Chemical\rBiology, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence P.","family":"McIntosh","sequence":"additional","affiliation":[{"name":"Department\rof Biochemistry and Molecular Biology, Department\rof Chemistry, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Garc\u00eda-Moreno E.","sequence":"additional","affiliation":[{"name":"Department\rof Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine Steen","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department\rof Biology, University of Copenhagen, Ole Maal\u00f8es Vej 5, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zigmantas","family":"Toleikis","sequence":"additional","affiliation":[{"name":"Department\rof Biology, University of Copenhagen, Ole Maal\u00f8es Vej 5, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaare","family":"Teilum","sequence":"additional","affiliation":[{"name":"Department\rof Biology, University of Copenhagen, Ole Maal\u00f8es Vej 5, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Erik","family":"Nielsen","sequence":"additional","affiliation":[{"name":"School\rof Biomolecular and Biomedical Science, Centre for Synthesis and Chemical\rBiology, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1073\/pnas.95.11.5950","volume":"95","author":"Warshel A.","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.2563171","volume":"243","author":"Varadarajan R.","year":"1989","journal-title":"Science"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1126\/science.280.5371.1934","volume":"280","author":"Luecke H.","year":"1998","journal-title":"Science"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.280.5360.69","volume":"280","author":"Doyle D.","year":"1998","journal-title":"Science"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/protein\/12.8.657","volume":"12","author":"Nielsen J. E.","year":"1999","journal-title":"Protein Eng."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1110\/ps.0229903","volume":"12","author":"Nielsen J. E.","year":"2003","journal-title":"Protein Sci."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1002\/prot.23091","volume":"79","author":"Carstensen T.","year":"2011","journal-title":"Proteins"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0033583500005333","volume":"17","author":"Warshel A.","year":"1984","journal-title":"Q. Rev. Biophys."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"16096","DOI":"10.1073\/pnas.1004213107","volume":"107","author":"Isom D.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1110\/ps.062538707","volume":"16","author":"Tynan-Connolly B. M.","year":"2007","journal-title":"Protein Sci."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1021\/bi900526z","volume":"48","author":"Hernandez G.","year":"2009","journal-title":"Biochemistry"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1021\/bi00355a035","volume":"25","author":"Churg A.","year":"1986","journal-title":"Biochemistry"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/prot.1106","volume":"44","author":"Schutz C. N.","year":"2001","journal-title":"Proteins"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1063\/1.1744199","volume":"28","author":"Schneider W.","year":"1958","journal-title":"J. Chem. Phys."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1139\/v60-040","volume":"38","author":"Buckingham A. D.","year":"1960","journal-title":"Can. J. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.jinorgbio.2006.03.014","volume":"100","author":"LeMaster D. M.","year":"2006","journal-title":"J. Inorg. Biochem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"9556","DOI":"10.1021\/ja034855y","volume":"125","author":"Boyd J.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/prot.22621","volume":"78","author":"Kukic P.","year":"2010","journal-title":"Proteins"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/prot.21929","volume":"72","author":"Hass M. A.","year":"2008","journal-title":"Proteins"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1021\/bi701708u","volume":"47","author":"Webb L. J.","year":"2008","journal-title":"Biochemistry"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.1127159","volume":"313","author":"Suydam I. T.","year":"2006","journal-title":"Science"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"6851","DOI":"10.1021\/ja00068a049","volume":"115","author":"Pearson J.","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/bj1650223","volume":"165","author":"Perkins S. J.","year":"1977","journal-title":"Biochem. J."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/jmrb.1993.1008","volume":"101","author":"Williamson M. P.","year":"1993","journal-title":"J. Magn. Reson., Ser. B"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"7784","DOI":"10.1021\/ja00096a039","volume":"116","author":"de Dios A.","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bpc.2009.01.005","volume":"141","author":"Anderson J. S.","year":"2009","journal-title":"Biophys. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0022-2836(02)00159-6","volume":"318","author":"Thomsen J.","year":"2002","journal-title":"J. Mol. Biol."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1021\/ja1096539","volume":"133","author":"Jensen K.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1021\/ja020066p","volume":"124","author":"Tollinger M.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref30\/cit30","first-page":"342","volume":"100","author":"Augspurger J.","year":"1992","journal-title":"J. Magn. Reson."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1021\/ja00845a022","volume":"97","author":"Batchelor J.","year":"1975","journal-title":"J. Am. Chem. Soc."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1147\/rd.453.0427","volume":"45","author":"Baker N. A.","year":"2001","journal-title":"IBM J. Res. Dev."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/prot.21123","volume":"65","author":"Hornak V.","year":"2006","journal-title":"Proteins"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"8910","DOI":"10.1063\/1.481505","volume":"112","author":"Mahoney M.","year":"2000","journal-title":"J. Chem. Phys."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","volume":"81","author":"Berendsen H.","year":"1984","journal-title":"J. Chem. Phys."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"15346","DOI":"10.1073\/pnas.0702112104","volume":"104","author":"Sakurai K.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1002\/prot.22825","volume":"78","author":"Tomlinson J. H.","year":"2010","journal-title":"Proteins"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"10444","DOI":"10.1021\/ja0112700","volume":"123","author":"Crowley P. B.","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"12672","DOI":"10.1002\/chem.200901410","volume":"15","author":"Crowley P.","year":"2009","journal-title":"Chem.\u2014Eur. J."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"6583","DOI":"10.1021\/bi800125h","volume":"47","author":"Crowley P.","year":"2008","journal-title":"Biochemistry"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10858-011-9537-x","volume":"51","author":"McIntosh L. P.","year":"2011","journal-title":"J. Biomol. NMR"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"7383","DOI":"10.1021\/bi700249m","volume":"46","author":"Schubert M.","year":"2007","journal-title":"Biochemistry"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/prot.22470","volume":"77","author":"Casta\u00f1eda C.","year":"2009","journal-title":"Proteins"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nsb0296-149","volume":"3","author":"White A.","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/prot.22611","volume":"78","author":"Farrell D.","year":"2010","journal-title":"Proteins"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/prot.22886","volume":"79","author":"Webb H.","year":"2011","journal-title":"Proteins"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/S0006-3495(94)80900-2","volume":"66","author":"Bartik K.","year":"1994","journal-title":"Biophys. J."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1006\/jmbi.1994.1301","volume":"238","author":"Antosiewicz J.","year":"1994","journal-title":"J. Mol. Biol."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"10901","DOI":"10.1073\/pnas.0511156103","volume":"103","author":"Best R.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0022-2836(85)90096-8","volume":"181","author":"Bone S.","year":"1985","journal-title":"J. Mol. Biol."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/prot.1053","volume":"43","author":"Nielsen J. E.","year":"2001","journal-title":"Proteins"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"17373","DOI":"10.1021\/jp960111d","volume":"100","author":"Demchuk E.","year":"1996","journal-title":"J. Phys. Chem."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/protein\/8.3.243","volume":"8","author":"Karshikoff A.","year":"1995","journal-title":"Protein Eng."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/prot.340150304","volume":"15","author":"Yang A. S.","year":"1993","journal-title":"Proteins"},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/S0006-3495(97)78851-9","volume":"72","author":"Alexov E. G.","year":"1997","journal-title":"Biophys. J."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"10219","DOI":"10.1021\/bi00496a010","volume":"29","author":"Bashford D.","year":"1990","journal-title":"Biochemistry"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"W368","DOI":"10.1093\/nar\/gki464","volume":"33","author":"Gordon J. C.","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1110\/ps.8.2.418","volume":"8","author":"Warwicker J.","year":"1999","journal-title":"Protein Sci."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.bbapap.2006.08.007","volume":"1764","author":"Warshel A.","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"9436","DOI":"10.1021\/ja00025a002","volume":"113","author":"Osapay K.","year":"1991","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja406995j","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T08:31:45Z","timestamp":1681461105000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja406995j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,31]]},"references-count":60,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2013,11,13]]}},"alternative-id":["10.1021\/ja406995j"],"URL":"https:\/\/doi.org\/10.1021\/ja406995j","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718144398.793485550","asserted-by":"object"}]},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,31]]}}}