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The reactions are catalyzed by chiral squaramides and afford adducts in high yields (90\u201399%) and with excellent enantioselectivities (85\u201398%). The addition products are unmasked to produce dicyanohydrins that, upon treatment with a variety of nucleophiles, provide \u03b3-keto acids, esters, and amides. The use of this umpolung synthon has enabled, in enantiomerically enriched form, the first total synthesis of the prenylated phenol (+)-fornicin C.<\/jats:p>","DOI":"10.1021\/ja409012q","type":"journal-article","created":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T20:36:15Z","timestamp":1380832575000},"page":"16050-16053","source":"Crossref","is-referenced-by-count":144,"title":["Squaramide-Catalyzed\nEnantioselective Michael Addition\nof Masked Acyl Cyanides to Substituted Enones"],"prefix":"10.1021","volume":"135","author":[{"given":"Kin S.","family":"Yang","sequence":"first","affiliation":[{"name":"The University of Chicago , , , ,","place":["Chicago, Illinois, United States, 60637"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette E.","family":"Nibbs","sequence":"additional","affiliation":[{"name":"The University of Chicago , , , ,","place":["Chicago, Illinois, United States, 60637"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunus E.","family":"Tu\u0308rkmen","sequence":"additional","affiliation":[{"name":"The University of Chicago , , , ,","place":["Chicago, Illinois, United States, 60637"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viresh H.","family":"Rawal","sequence":"additional","affiliation":[{"name":"The University of Chicago , , , ,","place":["Chicago, Illinois, United States, 60637"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,10,3]]},"reference":[{"key":"2026090217121465700_cit1a","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/cber.19510840713","author":"Wittig","year":"1951","journal-title":"Chem. 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