{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:47:45Z","timestamp":1789886865909,"version":"4.0.1"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":366,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Construction of self-illuminating semiconducting nanocrystals, also called quantum dots (QDs), has attracted much attention recently due to their potential as highly sensitive optical probes for biological imaging applications. Here we prepared a self-illuminating QD system by doping positron-emitting radionuclide 64Cu into CdSe\/ZnS core\/shell QDs via a cation-exchange reaction. The 64Cu-doped CdSe\/ZnS QDs exhibit efficient Cerenkov resonance energy transfer (CRET). The signal of 64Cu can accurately reflect the biodistribution of the QDs during circulation with no dissociation of 64Cu from the nanoparticles. We also explored this system for in vivo tumor imaging. This nanoprobe showed high tumor-targeting ability in a U87MG glioblastoma xenograft model (12.7% ID\/g at 17 h time point) and feasibility for in vivo luminescence imaging of tumor in the absence of excitation light. The availability of these self-illuminating integrated QDs provides an accurate and convenient tool for in vivo tumor imaging and detection.<\/jats:p>","DOI":"10.1021\/ja410438n","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T18:47:03Z","timestamp":1389206823000},"page":"1706-1709","source":"Crossref","is-referenced-by-count":164,"title":["Self-Illuminating 64Cu-Doped CdSe\/ZnS Nanocrystals for in Vivo Tumor Imaging"],"prefix":"10.1021","volume":"136","author":[{"given":"Xiaolian","family":"Sun","sequence":"first","affiliation":[{"name":"National Institute of Biomedical Imaging and Bioengineering , , , , ,","place":["Bethesda, Maryland, United States, 20892"]},{"name":"National Institutes of Health , , , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglu","family":"Huang","sequence":"additional","affiliation":[{"name":"National Institute of Biomedical Imaging and Bioengineering , , , , ,","place":["Bethesda, Maryland, United States, 20892"]},{"name":"National Institutes of Health , , , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxia","family":"Guo","sequence":"additional","affiliation":[{"name":"National Institute of Biomedical Imaging and Bioengineering , , , , ,","place":["Bethesda, Maryland, United States, 20892"]},{"name":"National Institutes of Health , , , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Brown University , , , ,","place":["Providence, Rhode Island, United States, 02912"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Ding","sequence":"additional","affiliation":[{"name":"Georgia Institute of Technology , , , ,","place":["Atlanta, Georgia, United States, 30332"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Niu","sequence":"additional","affiliation":[{"name":"National Institute of Biomedical Imaging and Bioengineering , , , , ,","place":["Bethesda, Maryland, United States, 20892"]},{"name":"National Institutes of Health , , , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wang","sequence":"additional","affiliation":[{"name":"Ocean NanoTech LLC , , ,","place":["Springdale, Arkansas, United States, 72764"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale O.","family":"Kiesewetter","sequence":"additional","affiliation":[{"name":"National Institute of Biomedical Imaging and Bioengineering , , , , ,","place":["Bethesda, Maryland, United States, 20892"]},{"name":"National Institutes of Health , , , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Georgia Institute of Technology , , , ,","place":["Atlanta, Georgia, United States, 30332"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Brown University , , , ,","place":["Providence, Rhode Island, United States, 02912"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"National Institute of Biomedical Imaging and Bioengineering , , , , ,","place":["Bethesda, Maryland, United States, 20892"]},{"name":"National Institutes of Health , , , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,1,8]]},"reference":[{"key":"2026090108014772700_cit1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nbt1074","volume":"23","author":"Ntziachristos","year":"2005","journal-title":"Nat. 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