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We found that Fer-1 inhibited cell death in cellular models of Huntington\u2019s disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.<\/jats:p>","DOI":"10.1021\/ja411006a","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T20:10:07Z","timestamp":1393963807000},"page":"4551-4556","source":"Crossref","is-referenced-by-count":1088,"title":["Ferrostatins\nInhibit Oxidative Lipid Damage and Cell\nDeath in Diverse Disease Models"],"prefix":"10.1021","volume":"136","author":[{"given":"Rachid","family":"Skouta","sequence":"first","affiliation":[{"name":"Columbia University , , 550 West 120th Street Northwest Corner Building, MC 4846 , ,","place":["New York, New York, United States, 10027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Columbia University , , 550 West 120th Street Northwest Corner Building, MC 4846 , ,","place":["New York, New York, United States, 10027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital and Harvard Medical School , , , ,","place":["Boston, Massachusetts, United States, 02115"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise E.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Duke University Medical Center , , , ,","place":["Durham, North Carolina, United States, 27704"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Orman","sequence":"additional","affiliation":[{"name":"Columbia University , , 550 West 120th Street Northwest Corner Building, MC 4846 , ,","place":["New York, New York, United States, 10027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Shimada","sequence":"additional","affiliation":[{"name":"Columbia University , , 550 West 120th Street Northwest Corner Building, MC 4846 , ,","place":["New York, New York, United States, 10027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital and Harvard Medical School , , , ,","place":["Boston, Massachusetts, United States, 02115"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Lo","sequence":"additional","affiliation":[{"name":"Duke University Medical Center , , , ,","place":["Durham, North Carolina, United States, 27704"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Weinberg","sequence":"additional","affiliation":[{"name":"University of Michigan , , , ,","place":["Ann Arbor, Michigan, United States, 48109"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Linkermann","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University , , ,","place":["Kiel, Germany, 24105"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent R.","family":"Stockwell","sequence":"additional","affiliation":[{"name":"Columbia University , , 550 West 120th Street Northwest Corner Building, MC 4846 , ,","place":["New York, New York, United States, 10027"]},{"name":"Columbia University , , , ,","place":["New York, New York, United States, 10027"]},{"name":"Columbia University , , , ,","place":["New York, New York, United States, 10027"]},{"name":"Columbia University , , , ,","place":["New York, New York, United States, 10027"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,3,4]]},"reference":[{"key":"2026090304380043700_cit1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","volume":"48","author":"Sena","year":"2012","journal-title":"Mol. 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