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Previously, we were inspired by host-defense peptides to develop nylon-3 polymers (poly-\u03b2-peptides) that are toxic toward the fungal pathogen Candida albicans but exert little effect on mammalian cells. Based on subsequent analysis of structure\u2013activity relationships among antifungal nylon-3 polymers, we have now identified readily prepared cationic homopolymers active against strains of C. albicans that are resistant to the antifungal drugs fluconazole and amphotericin B. These nylon-3 polymers are nonhemolytic. In addition, we have identified cationic\u2013hydrophobic copolymers that are highly active against a second fungal pathogen, Cryptococcus neoformans, and moderately active against a third pathogen, Aspergillus fumigatus.<\/jats:p>","DOI":"10.1021\/ja500036r","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T16:14:57Z","timestamp":1394208897000},"page":"4333-4342","source":"Crossref","is-referenced-by-count":125,"title":["Structure\u2013Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active against Drug-Resistant Strains of\n                    <i>Candida albicans<\/i>"],"prefix":"10.1021","volume":"136","author":[{"given":"Runhui","family":"Liu","sequence":"first","affiliation":[{"name":"University of Wisconsin , , , , ,","place":["Madison, Wisconsin, United States, 53706"]},{"name":"University of Wisconsin , , , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Wisconsin , , , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun P.","family":"Falk","sequence":"additional","affiliation":[{"name":"University of Wisconsin , , , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan P.","family":"Mowery","sequence":"additional","affiliation":[{"name":"University of Wisconsin , , , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy J.","family":"Karlsson","sequence":"additional","affiliation":[{"name":"University of Wisconsin , , , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Weisblum","sequence":"additional","affiliation":[{"name":"University of Wisconsin , , , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Palecek","sequence":"additional","affiliation":[{"name":"University of Wisconsin , , , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristyn S.","family":"Masters","sequence":"additional","affiliation":[{"name":"University of Wisconsin , , , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel H.","family":"Gellman","sequence":"additional","affiliation":[{"name":"University of Wisconsin , , , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,3,7]]},"reference":[{"key":"2026090123065295800_cit1","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. 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