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The new copper-based probe, CuDHX1, contains a dihydroxanthene (DHX) fluorophore and a cyclam derivative as a Cu(II) binding site. Upon reaction with HNO, CuDHX1 displays a five-fold fluorescence turn-on in cuvettes and is selective for HNO over thiols and reactive nitrogen and oxygen species. CuDHX1 can detect exogenously applied HNO in live mammalian cells and in conjunction with the zinc-specific, green-fluorescent sensor ZP1 can perform multicolor\/multianalyte microscopic imaging. These studies reveal that HNO treatment elicits an increase in the concentration of intracellular mobile zinc.<\/jats:p>","DOI":"10.1021\/ja500315x","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T13:48:58Z","timestamp":1393249738000},"page":"4697-4705","source":"Crossref","is-referenced-by-count":210,"title":["A Fast\nand Selective Near-Infrared Fluorescent Sensor\nfor Multicolor Imaging of Biological Nitroxyl (HNO)"],"prefix":"10.1021","volume":"136","author":[{"given":"Alexandra T.","family":"Wrobel","sequence":"first","affiliation":[{"name":"Massachusetts Institute of Technology , , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Deliz Liang","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Lippard","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Rivera-Fuentes","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"2026090118180952100_cit1","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/clinchem\/44.8.1809","volume":"44","author":"Cannon","year":"1998","journal-title":"Clin. 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