{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:33:14Z","timestamp":1785501194038,"version":"3.56.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2014,4,2]]},"DOI":"10.1021\/ja5013307","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T21:16:40Z","timestamp":1394227000000},"page":"5171-5176","source":"Crossref","is-referenced-by-count":57,"title":["Total Synthesis of Halichondrin A, the Missing Member in the Halichondrin Class of Natural Products"],"prefix":"10.1021","volume":"136","author":[{"given":"Atsushi","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Chemistry and\rChemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Chemistry and\rChemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Chemistry and\rChemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Kishi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and\rChemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,3,19]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1021\/ja00302a042","volume":"107","author":"Uemura D.","year":"1985","journal-title":"J. Am. Chem. Soc."},{"key":"ref1\/cit1b","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1351\/pac198658050701","volume":"58","author":"Hirata Y.","year":"1986","journal-title":"Pure Appl. Chem."},{"key":"ref2\/cit2a","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1021\/jm00115a027","volume":"34","author":"Pettit G. R.","year":"1991","journal-title":"J. Med. Chem."},{"key":"ref2\/cit2b","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1021\/jo00061a030","volume":"58","author":"Pettit G. R.","year":"1993","journal-title":"J. Org. Chem."},{"key":"ref2\/cit2c","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1016\/S0040-4039(00)78563-7","volume":"35","author":"Litaudon M.","year":"1994","journal-title":"Tetrahedron Lett."},{"key":"ref2\/cit2d","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1021\/jo962231n","volume":"62","author":"Litaudon M.","year":"1997","journal-title":"J. Org. Chem."},{"key":"ref2\/cit2e","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.bmc.2008.10.093","volume":"17","author":"Hickford S. J. H.","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref4\/cit4a","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1021\/ja00034a086","volume":"114","author":"Aicher T. D.","year":"1992","journal-title":"J. Am. Chem. Soc."},{"key":"ref4\/cit4b","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1021\/ja2108307","volume":"134","author":"Yamamoto A.","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref5\/cit5a","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1021\/ol702559e","volume":"9","author":"Henderson J. A.","year":"2007","journal-title":"Org. Lett."},{"key":"ref5\/cit5b","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1002\/anie.200806111","volume":"48","author":"Jackson K. L.","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref5\/cit5c","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1016\/0040-4039(91)80600-B","volume":"32","author":"Burke S. D.","year":"1991","journal-title":"Tetrahedron Lett."},{"key":"ref5\/cit5d","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.1021\/jo051479m","volume":"70","author":"Lambert W. T.","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref5\/cit5e","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1016\/S0040-4039(01)93872-9","volume":"30","author":"Kim S.","year":"1989","journal-title":"Tetrahedron Lett."},{"key":"ref5\/cit5f","doi-asserted-by":"crossref","first-page":"8193","DOI":"10.1016\/S0040-4039(00)61388-6","volume":"34","author":"Cooper A. J.","year":"1993","journal-title":"Tetrahedron Lett."},{"key":"ref5\/cit5g","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1055\/s-1994-22730","author":"Horita K.","year":"1994","journal-title":"Synlett"},{"key":"ref5\/cit5h","first-page":"386","author":"Horita K.","year":"2000","journal-title":"Phytochem. Phytopharm."},{"key":"ref5\/cit5i","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1016\/j.tetlet.2012.02.090","volume":"53","author":"Yadav J. S.","year":"2012","journal-title":"Tetrahedron Lett."},{"key":"ref6\/cit6a","unstructured":"aSaccomano, N. A.inComprehensive Organic Synthesis;Trost, B. M.; Fleming, I., Eds.Pergamon:Oxford, 1991; Vol.1, p173."},{"key":"ref6\/cit6b","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1021\/cr9703360","volume":"99","author":"F\u00fcrstner A.","year":"1999","journal-title":"Chem. Rev."},{"key":"ref6\/cit6c","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-1999-3672","author":"Wessjohann L. A.","year":"1999","journal-title":"Synthesis"},{"key":"ref6\/cit6d","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2183\/pjab.76.123","volume":"76","author":"Takai K.","year":"2000","journal-title":"Proc. Jpn. Acad., Ser. B"},{"key":"ref6\/cit6e","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/adsc.200700324","volume":"349","author":"Hargaden G. C.","year":"2007","journal-title":"Adv. Synth. Catal."},{"key":"ref7\/cit7a","doi-asserted-by":"crossref","first-page":"15387","DOI":"10.1021\/ja905843e","volume":"131","author":"Guo H.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref7\/cit7b","doi-asserted-by":"crossref","first-page":"15636","DOI":"10.1021\/ja9058475","volume":"131","author":"Kim D.-S.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref7\/cit7c","doi-asserted-by":"crossref","first-page":"15642","DOI":"10.1021\/ja9058487","volume":"131","author":"Dong C.-G.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref7\/cit7d","doi-asserted-by":"crossref","first-page":"16678","DOI":"10.1021\/ja9079308","volume":"131","author":"Liu X.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0040-4039(00)91672-1","volume":"33","author":"Buszek K. R.","year":"1992","journal-title":"Tetrahedron Lett."},{"key":"ref11\/cit11a","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1016\/S0040-4039(00)96327-5","volume":"28","author":"Aicher T. D.","year":"1987","journal-title":"Tetrahedron Lett."},{"key":"ref11\/cit11b","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1021\/ja1102822","volume":"133","author":"Usanov D. L.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref12\/cit12a","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1021\/ja00116a032","volume":"117","author":"Mahadevan A.","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"ref12\/cit12b","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0040-4039(00)91850-1","volume":"33","author":"Knapp S.","year":"1992","journal-title":"Tetrahedron Lett."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1021\/ja00483a042","volume":"100","author":"Reich H. J.","year":"1978","journal-title":"J. Am. Chem. Soc."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1021\/ol802711s","volume":"11","author":"Kang B.","year":"2009","journal-title":"Org. Lett."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"7535","DOI":"10.1016\/S0040-4039(02)01819-1","volume":"43","author":"Shiina I.","year":"2002","journal-title":"Tetrahedron Lett."},{"key":"ref19\/cit19a","unstructured":"aref20."},{"key":"ref19\/cit19b","doi-asserted-by":"crossref","first-page":"7770","DOI":"10.1021\/ja047826b","volume":"126","author":"Namba K.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1021\/jo951877x","volume":"61","author":"Hart J. B.","year":"1996","journal-title":"J. Org. Chem."},{"key":"ref22\/cit22a","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1021\/ja0705487","volume":"129","author":"Phillips S. T.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref22\/cit22b","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1021\/ja906996c","volume":"132","author":"Fortner K. C.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref22\/cit22c","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1021\/ol1019663","volume":"12","author":"Ravindar K.","year":"2010","journal-title":"Org. Lett."},{"key":"ref22\/cit22d","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1021\/ol102201z","volume":"12","author":"Tlais S. F.","year":"2010","journal-title":"Org. Lett."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0040-4039(00)91673-3","volume":"33","author":"Fang F. G.","year":"1992","journal-title":"Tetrahedron Lett."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja5013307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T22:15:29Z","timestamp":1681596929000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja5013307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,19]]},"references-count":43,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2014,4,2]]}},"alternative-id":["10.1021\/ja5013307"],"URL":"https:\/\/doi.org\/10.1021\/ja5013307","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,19]]}}}