{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:14:42Z","timestamp":1788340482765,"version":"build-2803163510"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T00:00:00Z","timestamp":1433548800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DBI-0619576"],"award-info":[{"award-number":["DBI-0619576"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1GM087581"],"award-info":[{"award-number":["RO1GM087581"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000879","name":"Alfred P. Sloan Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100000879","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In hydroformylation, phosphorus-based directing groups have been consistently successful at placing the aldehyde on the carbon proximal to the directing group. The design and synthesis of a novel catalytic directing group are reported that promotes aldehyde formation on the carbon distal relative to the directing functionality. This scaffolding ligand, which operates through a reversible covalent bond to the substrate, has been applied to the diastereoselective hydroformylation of homoallylic alcohols to afford \u03b4-lactones selectively. Altering the distance between the alcohol and the olefin revealed that homoallylic alcohols gives the distal lactone with the highest levels of regioselectivity.<\/jats:p>","DOI":"10.1021\/ja504247g","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T08:14:35Z","timestamp":1402042475000},"page":"8556-8559","source":"Crossref","is-referenced-by-count":36,"title":["Distal-Selective\nHydroformylation using Scaffolding\nCatalysis"],"prefix":"10.1021","volume":"136","author":[{"given":"Candice L.","family":"Joe","sequence":"first","affiliation":[{"name":"Boston College , , , ,","place":["Chestnut Hill, Massachusetts, United States, 02467"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Blaisdell","sequence":"additional","affiliation":[{"name":"Boston College , , , ,","place":["Chestnut Hill, Massachusetts, United States, 02467"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison F.","family":"Geoghan","sequence":"additional","affiliation":[{"name":"Boston College , , , ,","place":["Chestnut Hill, Massachusetts, United States, 02467"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian L.","family":"Tan","sequence":"additional","affiliation":[{"name":"Boston College , , , ,","place":["Chestnut Hill, Massachusetts, United States, 02467"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"2026090204223138500_cit1","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1021\/cr3001803","volume":"112","author":"Franke","year":"2012","journal-title":"Chem. Rev."},{"key":"2026090204223138500_cit2a","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1021\/ar7001039","volume":"40","author":"Klosin","year":"2007","journal-title":"Acc. Chem. Res."},{"key":"2026090204223138500_cit2b","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.tetasy.2010.05.037","volume":"21","author":"Gual","year":"2010","journal-title":"Tetrahedron: Asymmetry"},{"key":"2026090204223138500_cit2c","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.tetasy.2004.04.039","volume":"15","author":"Die\u0301guez","year":"2004","journal-title":"Tetrahedron: Asymmetry"},{"key":"2026090204223138500_cit2d","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1021\/cr00039a008","volume":"95","author":"Agbossou","year":"1995","journal-title":"Chem. Rev."},{"key":"2026090204223138500_cit2e","first-page":"35","volume":"18","author":"Claver","year":"2006","journal-title":"Top. Organomet. Chem."},{"key":"2026090204223138500_cit2f","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1002\/anie.201311291","volume":"53","author":"Jouffroy","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026090204223138500_cit3","doi-asserted-by":"crossref","first-page":"14027","DOI":"10.1021\/ja106674n","volume":"132","author":"McDonald","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"2026090204223138500_cit4","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1002\/anie.201000955","volume":"49","author":"Zhang","year":"2010","journal-title":"Angew. Chem., Int.\nEd."},{"key":"2026090204223138500_cit5","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1002\/anie.201108203","volume":"51","author":"Noonan","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026090204223138500_cit6a","doi-asserted-by":"crossref","first-page":"11344","DOI":"10.1021\/ja063294i","volume":"128","author":"Kuil","year":"2006","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026090204223138500_cit6b","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1021\/ja211455j","volume":"134","author":"Gadzikwa","year":"2012","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026090204223138500_cit6c","first-page":"7091","volume":"18","author":"Bellini","year":"2012","journal-title":"Chem.\u2500Eur. J."},{"key":"2026090204223138500_cit7a","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1039\/c39870000724","volume":"21","author":"Jackson","year":"1987","journal-title":"J. Chem. Soc. Chem. Commun."},{"key":"2026090204223138500_cit7b","doi-asserted-by":"crossref","first-page":"11514","DOI":"10.1021\/ja016978t","volume":"123","author":"Krauss","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"2026090204223138500_cit8","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1002\/ejoc.200700120","volume":"15","author":"Breit","year":"2007","journal-title":"Eur. J. Org. Chem."},{"key":"2026090204223138500_cit9a","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1039\/b311378g","volume":"24","author":"Breit","year":"2004","journal-title":"Chem. Commun."},{"key":"2026090204223138500_cit9b","doi-asserted-by":"crossref","first-page":"7346","DOI":"10.1002\/anie.200802296","volume":"47","author":"Gru\u0308nanger","year":"2008","journal-title":"Angew.\nChem., Int. Ed."},{"key":"2026090204223138500_cit9c","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1021\/ol1028546","volume":"13","author":"Usui","year":"2011","journal-title":"Org. Lett."},{"key":"2026090204223138500_cit9d","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/anie.200905949","volume":"49","author":"Gru\u0308nanger","year":"2010","journal-title":"Angew.\nChem., Int. Ed."},{"key":"2026090204223138500_cit9e","first-page":"8555","volume":"17","author":"Ueki","year":"2011","journal-title":"Chem.\u2500Eur.\nJ."},{"key":"2026090204223138500_cit10a","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.1021\/ja803011d","volume":"130","author":"Lightburn","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"2026090204223138500_cit10b","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1021\/ol900921e","volume":"11","author":"Worthy","year":"2009","journal-title":"Org. Lett."},{"key":"2026090204223138500_cit10c","doi-asserted-by":"crossref","first-page":"11841","DOI":"10.1021\/ja1036226","volume":"132","author":"Sun","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"2026090204223138500_cit10d","doi-asserted-by":"crossref","first-page":"14757","DOI":"10.1021\/ja107433h","volume":"132","author":"Worthy","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"2026090204223138500_cit10e","doi-asserted-by":"crossref","first-page":"7590","DOI":"10.1021\/jo201328d","volume":"76","author":"Joe","year":"2011","journal-title":"J. Org. Chem."},{"key":"2026090204223138500_cit10f","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1021\/ol200782d","volume":"13","author":"Lightburn","year":"2011","journal-title":"Org. Lett."},{"key":"2026090204223138500_cit11a","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1021\/ic00219a050","volume":"24","author":"Lewis","year":"1985","journal-title":"Inorg. Chem."},{"key":"2026090204223138500_cit11b","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1021\/ja00270a036","volume":"108","author":"Lewis","year":"1986","journal-title":"J. Am. Chem. Soc."},{"key":"2026090204223138500_cit11c","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1039\/c39860000977","author":"Preston","year":"1986","journal-title":"J. Chem. Soc.,\nChem. Commun."},{"key":"2026090204223138500_cit11d","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1021\/ar700133y","volume":"41","author":"Park","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"2026090204223138500_cit11e","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/anie.200390037","volume":"42","author":"Bedford","year":"2003","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026090204223138500_cit11f","doi-asserted-by":"crossref","first-page":"8669","DOI":"10.1021\/jo030157k","volume":"68","author":"Bedford","year":"2003","journal-title":"J. Org. Chem."},{"key":"2026090204223138500_cit11g","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1016\/j.tetlet.2003.09.151","volume":"44","author":"Oi","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"2026090204223138500_cit11h","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1039\/B610038D","author":"Carrio\u0301n","year":"2006","journal-title":"Chem. Commun."},{"key":"2026090204223138500_cit11i","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.1021\/om050700i","volume":"24","author":"Lewis","year":"2005","journal-title":"Organometallics"},{"key":"2026090204223138500_cit12","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1016\/S0040-4039(00)94241-2","volume":"27","author":"Burke","year":"1986","journal-title":"Tetrahedron Lett."},{"key":"2026090204223138500_cit13a","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/anie.200703192","volume":"47","author":"S\u030cmejkal","year":"2008","journal-title":"Angew.\nChem., Int. Ed."},{"key":"2026090204223138500_cit13b","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1002\/anie.201209582","volume":"52","author":"Dydio","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026090204223138500_cit13c","first-page":"2470","volume":"16","author":"S\u030cmejkal","year":"2010","journal-title":"Chem.\u2500Eur.\nJ."},{"key":"2026090204223138500_cit13d","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/anie.201005173","volume":"50","author":"Dydio","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026090204223138500_cit14a","doi-asserted-by":"crossref","first-page":"8167","DOI":"10.1002\/anie.201103470","volume":"50","author":"Sun","year":"2011","journal-title":"Angew. Chem.,\nInt. Ed."},{"key":"2026090204223138500_cit14b","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1021\/ja3027086","volume":"134","author":"Worthy","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"2026090204223138500_cit14c","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1039\/C2CC33633B","volume":"49","author":"Giustra","year":"2013","journal-title":"Chem. Commun."},{"key":"2026090204223138500_cit14d","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nchem.1726","volume":"5","author":"Sun","year":"2013","journal-title":"Nat. Chem."},{"key":"2026090204223138500_cit14e","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1021\/ol402023c","volume":"15","author":"Blaisdell","year":"2013","journal-title":"Org. Lett."},{"key":"2026090204223138500_cit19a","doi-asserted-by":"crossref","first-page":"14352","DOI":"10.1021\/ja909619a","volume":"132","author":"Watkins","year":"2010","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja504247g","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/136\/24\/8556\/8037553\/ja504247g.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/136\/24\/8556\/8037553\/ja504247g.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:22:44Z","timestamp":1788337364000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/136\/24\/8556\/783625\/Distal-Selective-Hydroformylation-using"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,6]]},"references-count":47,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2014,6,6]]},"published-print":{"date-parts":[[2014,6,18]]}},"URL":"https:\/\/doi.org\/10.1021\/ja504247g","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,6]]}}}