{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:08:21Z","timestamp":1790402901049,"version":"4.1.0"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"46","license":[{"start":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T00:00:00Z","timestamp":1446854400000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM-59426"],"award-info":[{"award-number":["GM-59426"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A convergent diastereo- and enantioselective total synthesis of anticancer and antifungal macrocyclic natural product disorazole C1 is reported. The central feature of the successful route is the application of catalytic Z-selective cross-metathesis (CM). Specifically, we illustrate that catalyst-controlled stereoselective CM can be performed to afford structurally complex Z-alkenyl\u2013B(pin) as well as Z-alkenyl iodide compounds reliably, efficiently, and with high selectivity (pin = pinacolato). The resulting intermediates are then joined in a single-step operation through catalytic inter- and intramolecular cross-coupling to furnish the desired 30-membered ring macrocycle containing the critical (Z,Z,E)-triene moieties.<\/jats:p>","DOI":"10.1021\/ja509973r","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T14:20:37Z","timestamp":1415370037000},"page":"16136-16139","source":"Crossref","is-referenced-by-count":74,"title":["Catalytic\n                    <i>Z<\/i>\n                    -Selective Cross-Metathesis\nin Complex Molecule Synthesis: A Convergent Stereoselective Route\nto Disorazole C1"],"prefix":"10.1021","volume":"136","author":[{"given":"Alexander W. 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