{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:09:44Z","timestamp":1791400184101,"version":"4.3.3"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"46","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccbyncnd_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM069990"],"award-info":[{"award-number":["R01GM069990"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A general, asymmetric synthesis of amino acid derivatives is reported. Masked acyl cyanide (MAC) reagents are shown to be effective umpolung synthons for enantioselective additions to N-Boc-aldimines. The reactions are catalyzed by a modified cinchona alkaloid, which can function as a bifunctional, hydrogen bonding catalyst, and afford adducts in excellent yields (90\u201398%) and high enantioselectivities (up to 97.5:2.5 er). Unmasking the addition products gives acyl cyanide intermediates that are intercepted by a variety of nucleophiles to afford \u03b1-amino acid derivatives. Notably, the methodology provides an alternative method for peptide bond formation.<\/jats:p>","DOI":"10.1021\/ja510135t","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T06:37:35Z","timestamp":1415083055000},"page":"16148-16151","source":"Crossref","is-referenced-by-count":55,"title":["Synthesis of \u03b1-Amino Acid Derivatives and Peptides via Enantioselective Addition of Masked Acyl Cyanides to Imines"],"prefix":"10.1021","volume":"136","author":[{"given":"Kin S.","family":"Yang","sequence":"first","affiliation":[{"name":"The University of Chicago , , , ,","place":["Chicago, Illinois, United States, 60637"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viresh H.","family":"Rawal","sequence":"additional","affiliation":[{"name":"The University of Chicago , , , ,","place":["Chicago, Illinois, United States, 60637"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,11,4]]},"reference":[{"key":"2026090204550141000_cit1a","volume-title":"Asymmetric\nSynthesis and Application of \u03b1-Amino Acids","author":"Soloshonok","year":"2009"},{"key":"2026090204550141000_cit1b","volume-title":"Handbook\non Syntheses of Amino Acids: General Routes for the Syntheses of Amino\nAcids","author":"Blaskovich","year":"2010"},{"key":"2026090204550141000_cit2a","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1021\/cr00013a009","volume":"92","author":"Blaser","year":"1992","journal-title":"Chem. 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