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Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1021\/bi002690p","volume":"40","author":"Weber-Ban E.","year":"2001","journal-title":"Biochemistry"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"9459","DOI":"10.1021\/bi00029a022","volume":"34","author":"Peracchi A.","year":"1995","journal-title":"Biochemistry"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"9466","DOI":"10.1021\/bi00029a023","volume":"34","author":"Woehl E.","year":"1995","journal-title":"Biochemistry"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1021\/bi982919p","volume":"38","author":"Woehl E.","year":"1999","journal-title":"Biochemistry"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"16486","DOI":"10.1016\/S0021-9258(17)34032-2","volume":"269","author":"Ahmed S. A.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"29100","DOI":"10.1074\/jbc.271.46.29100","volume":"271","author":"Ahmed S. A.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.1021\/bi050056b","volume":"44","author":"Phillips R. S.","year":"2005","journal-title":"Biochemistry"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.abb.2007.11.003","volume":"470","author":"Phillips R. S.","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"ref22\/cit22","unstructured":"This strain is available from the ATCC as 87788."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1006\/prep.1996.0082","volume":"8","author":"Yang L.-H.","year":"1996","journal-title":"Protein Express. Purif."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/BF00652574","volume":"16","author":"Kitamura Y.","year":"1987","journal-title":"J. Sol. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1529\/biophysj.107.123893","volume":"94","author":"Torrent J.","year":"2008","journal-title":"Biophys. J."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.bbapap.2006.01.002","volume":"1764","author":"Torrent J.","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.biophys.36.040306.132608","volume":"36","author":"Munoz V.","year":"2007","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"15486","DOI":"10.1073\/pnas.2136623100","volume":"100","author":"Zhu Y.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. 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