{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:31:04Z","timestamp":1791412264252,"version":"4.3.3"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"46","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2009,11,25]]},"DOI":"10.1021\/ja903478s","type":"journal-article","created":{"date-parts":[[2009,10,29]],"date-time":"2009-10-29T18:01:45Z","timestamp":1256839305000},"page":"16689-16696","source":"Crossref","is-referenced-by-count":77,"title":["Preferential Interactions of Guanidinum Ions with Aromatic Groups over Aliphatic Groups"],"prefix":"10.1021","volume":"131","author":[{"given":"Philip E.","family":"Mason","sequence":"first","affiliation":[{"name":"Department of Food Science, Cornell University, Ithaca, New York 14853, Department of Biochemistry, Bristol University, Bristol BS8 1TD, United Kingdom, H. H. Wills Physics Laboratory, Bristol University, Bristol BS8 1TL, United Kingdom, and Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Dempsey","sequence":"additional","affiliation":[{"name":"Department of Food Science, Cornell University, Ithaca, New York 14853, Department of Biochemistry, Bristol University, Bristol BS8 1TD, United Kingdom, H. H. Wills Physics Laboratory, Bristol University, Bristol BS8 1TL, United Kingdom, and Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Neilson","sequence":"additional","affiliation":[{"name":"Department of Food Science, Cornell University, Ithaca, New York 14853, Department of Biochemistry, Bristol University, Bristol BS8 1TD, United Kingdom, H. H. Wills Physics Laboratory, Bristol University, Bristol BS8 1TL, United Kingdom, and Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve R.","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Food Science, Cornell University, Ithaca, New York 14853, Department of Biochemistry, Bristol University, Bristol BS8 1TD, United Kingdom, H. H. Wills Physics Laboratory, Bristol University, Bristol BS8 1TL, United Kingdom, and Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Brady","sequence":"additional","affiliation":[{"name":"Department of Food Science, Cornell University, Ithaca, New York 14853, Department of Biochemistry, Bristol University, Bristol BS8 1TD, United Kingdom, H. H. Wills Physics Laboratory, Bristol University, Bristol BS8 1TL, United Kingdom, and Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2009,10,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0065-3233(08)60401-5","volume":"23","author":"Tanford C.","year":"1968","journal-title":"Adv. Protein Chem."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0076-6879(86)31045-0","volume":"131","author":"Pace C. N.","year":"1986","journal-title":"Methods Enzymol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0022-2836(92)90963-K","volume":"226","author":"Makhatadze G. I.","year":"1992","journal-title":"J. Mol. Biol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1002\/pro.5560041020","volume":"4","author":"Myers J. K.","year":"1995","journal-title":"J. Protein Sci."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF01918191","volume":"24","author":"Hofmeister F.","year":"1888","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1021\/bi00320a004","volume":"23","author":"Arakawa T.","year":"1984","journal-title":"Biochemistry"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1021\/bi00699a005","volume":"13","author":"Lee J. C.","year":"1974","journal-title":"Biochemistry"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1021\/bi00320a005","volume":"23","author":"Arakawa T.","year":"1984","journal-title":"Biochemistry"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1017\/S0033583500005369","volume":"18","author":"Collins K. D.","year":"1985","journal-title":"Q. Rev. Biophys."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1110\/ps.ps.20801","volume":"10","author":"Courtenay E. S.","year":"2001","journal-title":"Protein Sci."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"13997","DOI":"10.1073\/pnas.0606236103","volume":"103","author":"Street T. O.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.1073\/pnas.92.12.5553","volume":"92","author":"Collins K. D.","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1073\/pnas.0735920100","volume":"100","author":"Mason P. E.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"12302","DOI":"10.1021\/ja026014h","volume":"124","author":"Hribar B.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"16825","DOI":"10.1073\/pnas.0809224105","volume":"105","author":"Rossky P. J.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"16928","DOI":"10.1073\/pnas.0808427105","volume":"105","author":"Hua L.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3233(08)60608-7","volume":"14","author":"Kauzmann W.","year":"1959","journal-title":"Adv. Protein Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"7133","DOI":"10.1021\/bi00483a001","volume":"29","author":"Dill K. A.","year":"1990","journal-title":"Biochemistry"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1016\/S0021-9258(18)51830-5","volume":"238","author":"Nozaki Y.","year":"1963","journal-title":"J. Biol. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/S0021-9258(19)77141-5","volume":"245","author":"Nozaki Y.","year":"1970","journal-title":"J. Biol. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1063\/1.1334678","volume":"114","author":"Sharp K. A.","year":"2001","journal-title":"J. Chem. Phys."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1021\/ja039335h","volume":"126","author":"Batchelor J. D.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"18417","DOI":"10.1073\/pnas.0606538103","volume":"103","author":"Rezus Y. L. A.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0301-4622(03)00095-4","volume":"105","author":"Soper A. K.","year":"2003","journal-title":"Biophys. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.1021\/ja00332a006","volume":"106","author":"Kuharski R. A.","year":"1984","journal-title":"J. Am. Chem. Soc."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1021\/j100372a093","volume":"94","author":"Muller N.","year":"1990","journal-title":"J. Phys. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"15065","DOI":"10.1073\/pnas.0507053102","volume":"102","author":"Auton M.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1073\/pnas.0812588106","volume":"106","author":"Lim W. K.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"15317","DOI":"10.1073\/pnas.0706251104","volume":"104","author":"Auton M.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1523410","volume":"257","author":"Neri D.","year":"1992","journal-title":"Science"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1126\/science.1060438","volume":"293","author":"Shortle D.","year":"2001","journal-title":"Science"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"11819","DOI":"10.1021\/bi701280p","volume":"46","author":"Chugh J.","year":"2007","journal-title":"Biochemistry"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1073\/pnas.92.1.185","volume":"92","author":"Scholtz J. M.","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/bi048389g","volume":"44","author":"Dempsey C. E.","year":"2005","journal-title":"Biochemistry"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jmb.2004.10.036","volume":"345","author":"Moglich A.","year":"2005","journal-title":"J. Mol. Biol."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"L04","DOI":"10.1529\/biophysj.107.108290","volume":"93","author":"Mason P. E.","year":"2007","journal-title":"Biophys. J."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1006\/jmbi.1994.1022","volume":"235","author":"Flocco M. M.","year":"1994","journal-title":"J. Mol. Biol."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1107\/S0021889806035059","volume":"39","author":"Kline S. R.","year":"2006","journal-title":"J. Appl. Crystallogr."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1021\/jp973084f","volume":"102","author":"MacKerell A. D.","year":"1998","journal-title":"J. Phys. Chem. B"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"24185","DOI":"10.1021\/jp052799c","volume":"109","author":"Mason P. E.","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"Jorgensen W. L.","year":"1983","journal-title":"J. Chem. Phys."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"Brooks B. R.","year":"1983","journal-title":"J. Comput. Chem."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/jcc.21287","volume":"30","author":"Brooks B. R.","year":"2009","journal-title":"J. Comput. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1080\/00268977700102571","volume":"34","author":"van Gunsteren W. F.","year":"1977","journal-title":"Mol. Phys."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","volume":"98","author":"Darden T.","year":"1993","journal-title":"J. Chem. Phys."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1039\/FT9908601503","volume":"86","author":"D\u2019Arrigo G.","year":"1990","journal-title":"J. Chem. Soc. Faraday Trans."},{"key":"ref47\/cit47","first-page":"61","volume":"113","author":"Alm\u00e1sy L.","year":"2004","journal-title":"J. Mol. Biol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cplett.2004.03.040","volume":"388","author":"Bako I.","year":"2004","journal-title":"Chem. Phys. Lett."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"11462","DOI":"10.1021\/ja040034x","volume":"126","author":"Mason P. E.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1021\/jp068581n","volume":"111","author":"Mason P. E.","year":"2007","journal-title":"J. Phys. Chem. B"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1021\/ja0564012","volume":"128","author":"Dempsey C. E.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"15895","DOI":"10.1021\/ja074719j","volume":"129","author":"Dempsey C. E.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature04162","volume":"437","author":"Chandler D.","year":"2005","journal-title":"Nature"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ja903478s","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T20:25:43Z","timestamp":1678220743000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ja903478s"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,29]]},"references-count":53,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2009,11,25]]}},"alternative-id":["10.1021\/ja903478s"],"URL":"https:\/\/doi.org\/10.1021\/ja903478s","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,29]]}}}