{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:20:55Z","timestamp":1788326455167,"version":"build-2803163510"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1R01GM121612"],"award-info":[{"award-number":["1R01GM121612"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000078","name":"Division of Materials Research","doi-asserted-by":"publisher","award":["2004947"],"award-info":[{"award-number":["2004947"]}],"id":[{"id":"10.13039\/100000078","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2021,1,27]]},"DOI":"10.1021\/jacs.0c12044","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T02:06:24Z","timestamp":1610676384000},"page":"1296-1300","source":"Crossref","is-referenced-by-count":52,"title":["Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation"],"prefix":"10.1021","volume":"143","author":[{"given":"Yang","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueguang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiru","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Union","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyu","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"},{"name":"Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8142-6702","authenticated-orcid":true,"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00321.x"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071144"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5054-y"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00109-3"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12089"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.12.032"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.5.8612494"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-328"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08248.x"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00144.x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08236.x"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2013.10.006"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10062440"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/nano7090241"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.263"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.01.006"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2014.04.008"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.11.032"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.09.060"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118425109"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.06.146"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b00795"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b07554"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/ja110833r"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0707463"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031477"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.334730"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05787"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201900531"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305804110"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12565"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12285717"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1064"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00675.x"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.0c12044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T05:35:07Z","timestamp":1682660107000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c12044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,12]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,1,27]]}},"alternative-id":["10.1021\/jacs.0c12044"],"URL":"https:\/\/doi.org\/10.1021\/jacs.0c12044","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,12]]}}}