{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:58:40Z","timestamp":1793354320912,"version":"4.5.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA249180"],"award-info":[{"award-number":["R01 CA249180"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R35 NS116846"],"award-info":[{"award-number":["R35 NS116846"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003975","name":"Myotonic Dystrophy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002243","name":"National Ataxia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2021,8,25]]},"DOI":"10.1021\/jacs.1c02248","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T11:45:50Z","timestamp":1628855150000},"page":"13044-13055","source":"Crossref","is-referenced-by-count":117,"title":["Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment"],"prefix":"10.1021","volume":"143","author":[{"given":"Peiyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Abegg","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuquan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael I.","family":"Benhamou","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4661-7252","authenticated-orcid":true,"given":"Jared","family":"Baisden","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gogce","family":"Crynen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab K.","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"California Institute for Biomedical Research (CALIBR), Scripps Research, La Jolla, California 92037, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6453-0244","authenticated-orcid":true,"given":"Alexander","family":"Adibekian","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Childs-Disney","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8486-1796","authenticated-orcid":true,"given":"Matthew D.","family":"Disney","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.168"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810137115"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2577-1"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-016-0960-6"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2119"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.05.015"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.7b00009"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1452"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.438"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00556.x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1840"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103735108"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nature09284"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75852"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800260115"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.09.010"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jm800790t"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.04.001"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3913"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b01233"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141230798"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914286117"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.09.004"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01471-07"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2003.08.002"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.019"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.04.008"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-008-3_17"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022296"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.23.2981"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2010.0120"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-015-0228-7"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2016.25"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.09.004"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2016.08.001"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/ar2002123"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv185"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.01.023"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00180"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b00610"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-8-r77"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.1c02248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T11:51:11Z","timestamp":1682423471000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.1c02248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":43,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2021,8,25]]}},"alternative-id":["10.1021\/jacs.1c02248"],"URL":"https:\/\/doi.org\/10.1021\/jacs.1c02248","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740642671.793588225","asserted-by":"object"}]},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]}}}