{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:43:22Z","timestamp":1793072602654,"version":"4.5.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA68682"],"award-info":[{"award-number":["CA68682"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["F-0018"],"award-info":[{"award-number":["F-0018"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A2B6002275"],"award-info":[{"award-number":["2018R1A2B6002275"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A3B1052702"],"award-info":[{"award-number":["2018R1A3B1052702"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019H1A2A1074096"],"award-info":[{"award-number":["2019H1A2A1074096"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002498","name":"Hyupsung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002498","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2021,9,8]]},"DOI":"10.1021\/jacs.1c03875","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T11:34:40Z","timestamp":1628595280000},"page":"14115-14124","source":"Crossref","is-referenced-by-count":95,"title":["A Small Molecule Strategy for Targeting Cancer Stem Cells in Hypoxic Microenvironments and Preventing Tumorigenesis"],"prefix":"10.1021","volume":"143","author":[{"given":"Ji Hyeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Chemistry, Korea University, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-2050","authenticated-orcid":true,"given":"Peter","family":"Verwilst","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Korea University, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1656-6362","authenticated-orcid":true,"given":"Miae","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Korea University, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Hyupsung University, Hwasung-si 18330, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-1325","authenticated-orcid":true,"given":"Jonathan L.","family":"Sessler","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyou","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Hyupsung University, Hwasung-si 18330, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3477-1172","authenticated-orcid":true,"given":"Jong Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Korea University, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1177\/2211068212454739"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/35102167"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/82_2010_75","volume-title":"Diverse Effects of Hypoxia on Tumor Progression","volume":"345","author":"Li Z.","year":"2010"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-4614-5915-6_2","volume-title":"Tumor Microenvironment and Cellular Stress","volume":"772","author":"Yun Z.","year":"2014"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1159\/000431060"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00379D"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0110-5"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201712920"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b06068"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07490"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.01.048"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00856"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201510443"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-00793-0"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2147\/HP.S93413"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1089-9"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R700043200"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7512632"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2809"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0251-y"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00557A"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00304A"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.034"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.11.093"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0429"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909690"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.550"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4261"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-015-0885-x"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-017-0011-9"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.01.012"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmx011"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/srep20051"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00975"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0336-y"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-9886-x"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160527113501"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2018.04.007"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2017.2258"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.85"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10903"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b00722"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.07.010"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54824-5"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2224"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13625"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207417"},{"key":"ref49\/cit49","first-page":"936","volume":"10","author":"Jian J.","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/bit.26845"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-6-31"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.21037\/sci.2018.02.02"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-017-0166-1"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201303411"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0656-7"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1186\/scrt506"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01104"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b00140"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.03.041"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2020.03.004"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9091"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2896"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.006"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2037"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.1c03875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T22:07:11Z","timestamp":1682633231000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.1c03875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,10]]},"references-count":64,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2021,9,8]]}},"alternative-id":["10.1021\/jacs.1c03875"],"URL":"https:\/\/doi.org\/10.1021\/jacs.1c03875","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,10]]}}}