{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:29:56Z","timestamp":1793334596703,"version":"4.5.0"},"reference-count":79,"publisher":"American Chemical Society (ACS)","issue":"43","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG058504"],"award-info":[{"award-number":["RF1AG058504"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P41GM132079"],"award-info":[{"award-number":["P41GM132079"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM118695"],"award-info":[{"award-number":["R01GM118695"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2021,11,3]]},"DOI":"10.1021\/jacs.1c06402","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T17:21:07Z","timestamp":1635268867000},"page":"18073-18090","source":"Crossref","is-referenced-by-count":18,"title":["Molecular Basis of Ca(II)-Induced Tetramerization and Transition-Metal Sequestration in Human Calprotectin"],"prefix":"10.1021","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0197-3878","authenticated-orcid":true,"given":"Robert","family":"Silvers","sequence":"first","affiliation":[{"name":"Department of Chemistry & Biochemistry, Florida State University, Tallahassee, Florida 32306, United States"},{"name":"Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules R.","family":"Stephan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-832X","authenticated-orcid":true,"given":"Robert G.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States"},{"name":"Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6153-8803","authenticated-orcid":true,"given":"Elizabeth M.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)93237-J"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.50.3.113"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-062917-012312"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03240130021018"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2836"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11950"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.20.12427"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.04.065"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220341110"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/ja407147d"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ja512204s"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1891"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b01212"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b06845"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/cb500792b"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152449"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00250"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-0305(99)00085-9"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/ja307974e"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/ja3096416"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC03287C"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1980.tb02754.x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7500-8_4"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.2210\/pdb5W1F\/pdb"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.8b00415"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1038"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.2210\/pdb1XK4\/pdb"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.2210\/pdb4GGF\/pdb"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.2210\/pdb4XJK\/pdb"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.2210\/pdb6DS2\/pdb"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444900002833"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1186\/s12900-016-0058-4"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.2210\/pdb1MR8\/pdb"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.2210\/pdb5HLV\/pdb"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.2210\/pdb5HLO\/pdb"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.5340"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2016.08.008"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.2210\/pdb5I8N\/pdb"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.2210\/pdb1IRJ\/pdb"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070255"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1139\/o98-062"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.07.004"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnmrs.2013.02.001"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-013-9741-y"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2239-0_2"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/bi00185a040"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006819"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/BF00211164"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1023\/B:JNMR.0000032523.00554.38"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/cr030413t"},{"key":"ref54\/cit54","unstructured":"Cavanagh, J. F. W. J.; Palmer, A. G., 3rd; Rance, M.; Skelton, N. J. Protein NMR Spectroscopy: Principles and Practice, 2nd ed. Academic Press: Amsterdam, 2007; p xxv, 885 pp."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-1-4419-7273-6_10","volume-title":"Folding of Disulfide Proteins","author":"Silvers R.","year":"2011"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175254"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1998.1483"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008268930690"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/ja982649y"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1998.1626"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008398227519"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1080\/00268979809483245"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13585"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008358030477"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011265430149"},{"key":"ref66\/cit66","unstructured":"Goddard, T. D.; Kneller, D. G. SPARKY, version 3.115; University of California, San Francisco, 2008."},{"key":"ref67\/cit67","unstructured":"The PyMOL Molecular Graphics System, version 1.8; Schrodinger, LLC, 2015."},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b06354"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2020.107689"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.2210\/pdb6ZDY\/pdb"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620665114"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904492106"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/nature11271"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b04380"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1021\/ar100110d"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(00)00093-9"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(03)00126-6"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-012-9661-2"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.2210\/pdb1NSH\/pdb"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.2210\/pdb2LUC\/pdb"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.2210\/pdb1QLS\/pdb"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.1c06402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T01:16:35Z","timestamp":1682558195000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.1c06402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,26]]},"references-count":79,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2021,11,3]]}},"alternative-id":["10.1021\/jacs.1c06402"],"URL":"https:\/\/doi.org\/10.1021\/jacs.1c06402","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,26]]}}}