{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:30:30Z","timestamp":1791894630883,"version":"4.3.4"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"16","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100018594","name":"Central University Basic Research Fund of China","doi-asserted-by":"publisher","award":["JKD01211520"],"award-info":[{"award-number":["JKD01211520"]}],"id":[{"id":"10.13039\/501100018594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011513","name":"State Key Laboratory of Bioreactor Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51621002"],"award-info":[{"award-number":["51621002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic\/Technology Research Leader","doi-asserted-by":"crossref","award":["20XD1421400"],"award-info":[{"award-number":["20XD1421400"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2022,4,27]]},"DOI":"10.1021\/jacs.2c00452","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T15:14:06Z","timestamp":1649949246000},"page":"7283-7294","source":"Crossref","is-referenced-by-count":73,"title":["Heterochiral \u03b2-Peptide Polymers Combating Multidrug-Resistant Cancers Effectively without Inducing Drug Resistance"],"prefix":"10.1021","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0573-3636","authenticated-orcid":true,"given":"Ning","family":"Shao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yuan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-5844","authenticated-orcid":true,"given":"Pengcheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0444-0324","authenticated-orcid":true,"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3462-7373","authenticated-orcid":true,"given":"Zihao","family":"Cong","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7668-7409","authenticated-orcid":true,"given":"Yueming","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-086X","authenticated-orcid":true,"given":"Runhui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China"},{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1529"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-018-9903-0"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2012.03.002"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22679"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12581"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093233"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3599"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.04.011"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1730-1"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1267"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3591"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00043"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau5480"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0058-8"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105276"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1039\/c8cc01926f"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02866"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2020.1740683"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2011.09.004"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/bi300836r"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00294"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/ja210569f"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.05.002"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2604-z"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1039\/d0bm01537g"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/nn400683s"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-4560-2"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36608-5"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090397"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.mct-10-0811"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.09.040"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202001108"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b01143"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/ja077288d"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/ja8069192"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/ja500036r"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/c9bm00248k"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00410"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01321"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20858-x"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00925-06"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200801523"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01320"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.381"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b11468"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2017.041"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2019.10"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1039\/c6cs00458j"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11082-3"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/nature17038"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201905091"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2018.1450910"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0130-9"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax9250"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1907"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00795"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c00452","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c00452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T04:08:43Z","timestamp":1682568523000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c00452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,14]]},"references-count":59,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,4,27]]}},"alternative-id":["10.1021\/jacs.2c00452"],"URL":"https:\/\/doi.org\/10.1021\/jacs.2c00452","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,14]]}}}