{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:22:06Z","timestamp":1792790526416,"version":"4.5.0"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21725204"],"award-info":[{"award-number":["21725204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22122104"],"award-info":[{"award-number":["22122104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Frontiers Science Center for New Organic Matter at Nankai University","award":["63181206"],"award-info":[{"award-number":["63181206"]}],"id":[{"id":"https:\/\/ror.org\/01y1kjr75","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2022,6,8]]},"DOI":"10.1021\/jacs.2c04620","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T11:36:17Z","timestamp":1653996977000},"page":"10080-10090","source":"Crossref","is-referenced-by-count":48,"title":["Construction of Complex Macromulticyclic Peptides via Stitching with Formaldehyde and Guanidine"],"prefix":"10.1021","volume":"144","author":[{"given":"Bo","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Wan","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanliang","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaokun","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Wen","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chu","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-3418","authenticated-orcid":true,"given":"Gang","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-5427","authenticated-orcid":true,"given":"Dong-Sheng","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-8702","authenticated-orcid":true,"given":"Xiao-Song","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"},{"name":"Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5067-9889","authenticated-orcid":true,"given":"Gong","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"},{"name":"Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"ref1\/cit1","volume-title":"Peptide Applications in Biomedicine, Biotechnology and Bioengineering","author":"Koutsopoulos S.","year":"2018","edition":"1"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-62703-544-6","volume-title":"Peptide Synthesis and Application","author":"Jensen K. J.","year":"2013","edition":"2"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12055"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00318"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00135-8"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5740"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2393"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00536"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-020-0420-9"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2013.864"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/pep2.24145"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nature19791"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/ja809005k"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/ja400119t"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1062"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1039\/c4cs00246f"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.2174\/0929866525666181120090650"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00744"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13178"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.8.3803"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099191"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311706110"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b02001"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b01624"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/c6sc05454d"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00269"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201911900"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax7344"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b03623"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201906514"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.184"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201502607"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/ja405106u"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813827"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201804506"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1487"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c06044"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201610942"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b00378"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/d1sc01174j"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170316120304"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202016267"},{"key":"ref43\/cit43","unstructured":"Reuss, G.; Disteldorf, W.; Gamer, A. O.; Hilt, A.\n                      Ullmann\u2019s Encyclopedia of Industrial Chemistry\n                      , 7th ed. Wiley: Weinheim, 2012; Vol. 15, pp 735\u2013768."},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elu037"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.r115.651679"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b01304"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/ja01188a018"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m310752200"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/bc050340f"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-019-0224-2"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16935-w"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20754-4"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.19.6470"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/ja0439017"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200702989"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/ja303436y"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12874"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(18)94475-3"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/ml5003508"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-017-0088"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201916380"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00605"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2004.04.137"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c04620","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c04620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T20:16:22Z","timestamp":1682453782000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c04620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,31]]},"references-count":63,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2022,6,8]]}},"alternative-id":["10.1021\/jacs.2c04620"],"URL":"https:\/\/doi.org\/10.1021\/jacs.2c04620","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,31]]}}}