{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:07:40Z","timestamp":1792534060173,"version":"4.5.0"},"reference-count":75,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000165","name":"Division of Chemistry","doi-asserted-by":"publisher","award":["1847932"],"award-info":[{"award-number":["1847932"]}],"id":[{"id":"10.13039\/100000165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM129496"],"award-info":[{"award-number":["GM129496"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2022,10,5]]},"DOI":"10.1021\/jacs.2c06497","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T06:50:21Z","timestamp":1663743021000},"page":"17876-17888","source":"Crossref","is-referenced-by-count":80,"title":["Bioinformatic Atlas of Radical SAM Enzyme-Modified RiPP Natural Products Reveals an Isoleucine\u2013Tryptophan Crosslink"],"prefix":"10.1021","volume":"144","author":[{"given":"Kenzie A.","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-4854","authenticated-orcid":true,"given":"Mohammad R.","family":"Seyedsayamdost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2005.1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1039\/np9880500129"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201807844"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200390202"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-015-1723-5"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-013-1389-9"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomedchemau.2c00004"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-019-0107-1"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1039\/C2NP20085F"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1039\/D0NP00027B"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1039\/b714132g"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.10.027"},{"key":"ref14\/cit14","first-page":"1","volume-title":"Advances in Protein Chemistry","volume":"58","author":"Frey P. A.","year":"2001"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060713-035504"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/cr4004709"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.623793"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.04.001"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nature24624"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b10266"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b05151"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b11060"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b09210"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c05546"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c01507"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2237"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02560-21"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01090-8"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","DOI":"10.26434\/chemrxiv-2021-jnv18","volume-title":"Biosynthesis-Guided Discovery of Enteropeptins, Unusual Sactipeptides Containing an N-Methylornithine","author":"Clark K. A.","year":"2021"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-21"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00040-11"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b00735"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00614"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomedchemau.1c00048"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101881"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c00521"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fny112"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.tb02295.x"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2015.25"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2008.11.012"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091352"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.581249"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b01519"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz192"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49764-z"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901493116"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/ar700066p"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01174"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1238-8"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/nature06244"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.110434"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2017.05.009"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap9437"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6232"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00008-07"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110591"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00623"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00267-20"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd5680"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00771-0"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1722324115"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09898"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1039\/D0NP00097C"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b02277"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC01456K"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b03896"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00677"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b00124"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703663114"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.798"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b01147"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2101571118"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/cr0503097"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00892-6"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c06497","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c06497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T15:16:39Z","timestamp":1682608599000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c06497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,21]]},"references-count":75,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2022,10,5]]}},"alternative-id":["10.1021\/jacs.2c06497"],"URL":"https:\/\/doi.org\/10.1021\/jacs.2c06497","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,21]]}}}