{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:30:32Z","timestamp":1791361832299,"version":"4.3.1"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2020YFA0908100"],"award-info":[{"award-number":["2020YFA0908100"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020TQ0005"],"award-info":[{"award-number":["2020TQ0005"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018594","name":"Central University Basic Research Fund of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21904007"],"award-info":[{"award-number":["21904007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21925102"],"award-info":[{"award-number":["21925102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21991132"],"award-info":[{"award-number":["21991132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92056118"],"award-info":[{"award-number":["92056118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Center for Protein Sciences, Peking University"},{"DOI":"10.13039\/501100021187","name":"Beijing National Laboratory for Molecular Sciences","doi-asserted-by":"crossref","award":["BNLMS-CXXM-202006"],"award-info":[{"award-number":["BNLMS-CXXM-202006"]}],"id":[{"id":"10.13039\/501100021187","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011129","name":"State Key Laboratory of Biochemical Engineering","doi-asserted-by":"crossref","award":["2018KF-01"],"award-info":[{"award-number":["2018KF-01"]}],"id":[{"id":"10.13039\/501100011129","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2022,10,12]]},"DOI":"10.1021\/jacs.2c06532","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T08:57:04Z","timestamp":1664528224000},"page":"18387-18396","source":"Crossref","is-referenced-by-count":26,"title":["Mechano-bioconjugation Strategy Empowering Fusion Protein Therapeutics with Aggregation Resistance, Prolonged Circulation, and Enhanced Antitumor Efficacy"],"prefix":"10.1021","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-0640","authenticated-orcid":true,"given":"Yajie","family":"Liu","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Bai","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengliang","family":"Lyu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-3187","authenticated-orcid":true,"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-0792","authenticated-orcid":true,"given":"Wen-Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2399"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4305"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2017.11.007"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.961420"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2011.06.012"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.02.016"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.08.005"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.10.005"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-022-1243-5"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-015-0133-6"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2016.1165661"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB00808A"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/ja504390x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201600374"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202003708"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.04.023"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3109\/07388551.2013.834293"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201503440"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200900218"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2014.03.010"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.8b00548"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.9b00236"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1039\/C8PY01399C"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2013.04.017"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2020.123062"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2005.10.007"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161025831"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00248"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00797-8"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016863108"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.01.002"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b13017"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b06013"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.07.026"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00144"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.040"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","DOI":"10.1002\/9781119044123","volume-title":"The nature of the mechanical bond: From molecules to machines","author":"Bruns C. J.","year":"2016"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00146"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b07851"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1712788115"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.02.078"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5487.2129"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00156"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615862114"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzr024"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201511640"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.7b00104"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201705194"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201904943"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202005490"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c06169"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.giant.2022.100092"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006727"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b09454"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-021-00770-7"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2020.10.012"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.07.015"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/nri3845"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199019050-00003"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.110973"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1364"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzq058"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzv040"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.03.004"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.07.046"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1762"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120073"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4450"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC05171C"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119523"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.11.188"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00560"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.giant.2020.100040"},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41374-021-00714-2","volume":"102","author":"Morrison L. E.","year":"2022","journal-title":"Lab. Invest."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c06532","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c06532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T15:52:49Z","timestamp":1682437969000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c06532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":74,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2022,10,12]]}},"alternative-id":["10.1021\/jacs.2c06532"],"URL":"https:\/\/doi.org\/10.1021\/jacs.2c06532","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742344893.793595748","asserted-by":"object"}]},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]}}}