{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:40:15Z","timestamp":1792410015668,"version":"4.4.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"48","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R35 NS116846"],"award-info":[{"award-number":["R35 NS116846"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-19-1-0718"],"award-info":[{"award-number":["W81XWH-19-1-0718"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35 GM140890"],"award-info":[{"award-number":["R35 GM140890"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2022,12,7]]},"DOI":"10.1021\/jacs.2c08883","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T14:08:20Z","timestamp":1668780500000},"page":"21972-21979","source":"Crossref","is-referenced-by-count":37,"title":["Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion"],"prefix":"10.1021","volume":"144","author":[{"given":"Quentin M. R.","family":"Gibaut","sequence":"first","affiliation":[{"name":"Department of Chemistry, UF Scripps Biomedical Research and The Scripps Research Institute, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Akahori","sequence":"additional","affiliation":[{"name":"Department of Chemistry, UF Scripps Biomedical Research and The Scripps Research Institute, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Chemistry, UF Scripps Biomedical Research and The Scripps Research Institute, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Taghavi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, UF Scripps Biomedical Research and The Scripps Research Institute, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Chemistry, UF Scripps Biomedical Research and The Scripps Research Institute, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-900X","authenticated-orcid":true,"given":"Haruo","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, UF Scripps Biomedical Research and The Scripps Research Institute, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas S.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, UF Scripps Biomedical Research and The Scripps Research Institute, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-6693","authenticated-orcid":true,"given":"Brian M.","family":"Paegel","sequence":"additional","affiliation":[{"name":"Department of Chemistry, UF Scripps Biomedical Research and The Scripps Research Institute, Jupiter, Florida 33458, United States"},{"name":"Department of Chemistry and Pharmaceutical Sciences, University of California, Irvine, California 92617, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8486-1796","authenticated-orcid":true,"given":"Matthew D.","family":"Disney","sequence":"additional","affiliation":[{"name":"Department of Chemistry, UF Scripps Biomedical Research and The Scripps Research Institute, Jupiter, Florida 33458, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14263"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200300680"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1245831"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01891"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00855"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB00581A"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc15634a"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15076f"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.5b00106"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.211"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2022.116688"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24102026"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1177\/2472555220922802"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2021.06.001"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2114971119"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12674"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70204-1"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217317"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410781200"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw915"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.14.7388"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.14.7394"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.6.995"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm601"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh327"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00001"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1802.03426"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15351-4"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.5b00198"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC01474E"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-011-5604-0"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202116999"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.6b00192"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.7b00061"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1647164"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1101\/gr.8.3.186"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/D0MD00167H"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku275"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201301639"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/ja507448y"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/ja0471525"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.027367"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048825"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00827"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901484116"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2251"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24156-x"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100466200"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901893116"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv163"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/ng1610"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202200260"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800260115"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c01929"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c08883","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c08883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T08:03:36Z","timestamp":1682409816000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c08883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,18]]},"references-count":55,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2022,12,7]]}},"alternative-id":["10.1021\/jacs.2c08883"],"URL":"https:\/\/doi.org\/10.1021\/jacs.2c08883","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742415968.793597932","asserted-by":"object"}]},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,18]]}}}