{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:57:24Z","timestamp":1793062644065,"version":"4.5.0"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2019YFA09005000"],"award-info":[{"award-number":["2019YFA09005000"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021YFA0911400"],"award-info":[{"award-number":["2021YFA0911400"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M671027"],"award-info":[{"award-number":["2020M671027"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21878085"],"award-info":[{"award-number":["21878085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22008068"],"award-info":[{"award-number":["22008068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2023,2,22]]},"DOI":"10.1021\/jacs.2c11354","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T14:51:04Z","timestamp":1674226264000},"page":"4015-4025","source":"Crossref","is-referenced-by-count":84,"title":["Discovery of an Imine Reductase for Reductive Amination of Carbonyl Compounds with Sterically Challenging Amines"],"prefix":"10.1021","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-2054","authenticated-orcid":true,"given":"Fei-Fei","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Feng","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Xin","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yuan","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0140-3808","authenticated-orcid":true,"given":"Jian-He","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8708-0781","authenticated-orcid":true,"given":"Nicholas J.","family":"Turner","sequence":"additional","affiliation":[{"name":"School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-6047","authenticated-orcid":true,"given":"Gao-Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0021-z"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00383"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/9783527629541.ch7","volume-title":"Chiral Amine Synthesis: Methods, Developments and Applications","author":"Nugent T. C.","year":"2010"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s11244-013-0184-1"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2578"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2014.02.021"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201500213"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/0167-7799(89)90106-6"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-019-0249-z"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b04135"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201500785"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac9283"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107813"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2004.06.030"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2019.01.006"},{"key":"ref16\/cit16","unstructured":"Chen, H.; Collier, S. J.; Nazor, J.; Sukumaran, J.; Smith, D.; Moore, J. C.; Hughes, G.; Janey, J.; Huisman, G.; Novick, S.; Agard, N.; Alvizo, O.; Cope, G.; Yeo, W. L.; Ng, S. Engineered Imine Reductases and Methods for the Reductive Amination of Ketone and Amine Compounds. U.S. Patent 0,302,859 A1, 2013."},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201600647"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2016.11.022"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.110303"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/c0ob00353k"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-020-00606-w"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201503954"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b00782"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201500160"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201402797"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201402218"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcatb.2014.09.017"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201300539"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201500764"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2782"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay9320"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04458-x"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b03491"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1039\/c6gc03023h"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-019-0341-4"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-021-00671-5"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c03783"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001436"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.11.015"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1561506"},{"key":"ref41\/cit41","unstructured":"Thiel, O.; Bernard, C.; Larsen, R.; Martinelli, M. J.; Raza, M. T. Methods of Synthesizing Cinacalcet and Salts Thereof. WO 2009002427 A3, 2009."},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/ja5093612"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201701379"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.72"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201901491"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.057273"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14086"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1007\/s10158-012-0130-0"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m104167200"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4102-y"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707496"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081x(91)90076-w"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c11354","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c11354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T02:51:22Z","timestamp":1682563882000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c11354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,2,22]]}},"alternative-id":["10.1021\/jacs.2c11354"],"URL":"https:\/\/doi.org\/10.1021\/jacs.2c11354","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]}}}