{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:03:05Z","timestamp":1789614185490,"version":"build-2803163510"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:00:00Z","timestamp":1681603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001656","name":"Helmholtz-Gemeinschaft","doi-asserted-by":"publisher","award":["ZT-I-0003"],"award-info":[{"award-number":["ZT-I-0003"]}],"id":[{"id":"10.13039\/501100001656","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F??rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["CRSII5_193740"],"award-info":[{"award-number":["CRSII5_193740"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F??rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SNF 31003A_179275"],"award-info":[{"award-number":["SNF 31003A_179275"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["402723784"],"award-info":[{"award-number":["402723784"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["419071406"],"award-info":[{"award-number":["419071406"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2450"],"award-info":[{"award-number":["GRK2450"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2023,5,3]]},"DOI":"10.1021\/jacs.2c13653","type":"journal-article","created":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T18:48:36Z","timestamp":1681670916000},"page":"9571-9583","source":"Crossref","is-referenced-by-count":23,"title":["CAG-Repeat RNA Hairpin Folding and Recruitment to Nuclear Speckles with a Pivotal Role of ATP as a Cosolute"],"prefix":"10.1021","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-5583","authenticated-orcid":true,"given":"Alexander","family":"Hautke","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Physikalische und Theoretische Chemie, TU Braunschweig, Rebenring 56, Braunschweig 38106, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Voronin","sequence":"additional","affiliation":[{"name":"Steinbuch Centre for Computing, Karlsruher Institut f\u00fcr Technologie, Herrmann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen 76344, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fathia","family":"Idiris","sequence":"additional","affiliation":[{"name":"Steinbuch Centre for Computing, Karlsruher Institut f\u00fcr Technologie, Herrmann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen 76344, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Riel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physikalische und Theoretische Chemie, TU Braunschweig, Rebenring 56, Braunschweig 38106, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Lindner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physikalische und Theoretische Chemie, TU Braunschweig, Rebenring 56, Braunschweig 38106, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Leli\u00e8vre-B\u00fcttner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Universit\u00e4t Greifswald, Felix-Hausdorff-Stra\u00dfe 4, Greifswald 17487, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Universit\u00e4t Greifswald, Felix-Hausdorff-Stra\u00dfe 4, Greifswald 17487, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Appel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Universit\u00e4t Greifswald, Felix-Hausdorff-Stra\u00dfe 4, Greifswald 17487, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-1104","authenticated-orcid":true,"given":"Edoardo","family":"Fatti","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, ETH Z\u00fcrich, Otto-Stern-Weg 3, Z\u00fcrich 8093, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Weis","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, ETH Z\u00fcrich, Otto-Stern-Weg 3, Z\u00fcrich 8093, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Universit\u00e4t Greifswald, Felix-Hausdorff-Stra\u00dfe 4, Greifswald 17487, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0534-502X","authenticated-orcid":true,"given":"Alexander","family":"Schug","sequence":"additional","affiliation":[{"name":"J\u00fclich Supercomputing Centre, Forschungszentrum J\u00fclich, Wilhelm-Johnen-Str., J\u00fclich 52452, Germany"},{"name":"Faculty of Biology, University of Duisburg\/Essen, Essen 45141, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9309-1279","authenticated-orcid":true,"given":"Simon","family":"Ebbinghaus","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physikalische und Theoretische Chemie, TU Braunschweig, Rebenring 56, Braunschweig 38106, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,4,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.8.4.15397"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-40"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1323"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-017-0101-9"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2019.05.006"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00414"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd5991"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00097"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/bi401129r"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr299"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2514"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx759"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","unstructured":"Spector, D. L.; Lamond, A. I. Nuclear Speckles Cold Spring Harbor Perspectives in Biology; Cold Spring Harbor Lab, 2011; Vol. 3 (2), p a00646.","DOI":"10.1101\/cshperspect.a000646"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1209"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nature22386"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-00934-z"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/genes7120132"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-10-r100"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr095"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-021-04344-9"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005970"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1435"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/0471140864.ps2801s65"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201797109"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13025"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c09589"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/c6cp08167c"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b11039"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201510847"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/syst.202000052"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m109.078790"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/bi301103j"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/ja0463029"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1039\/d0cs00594k"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1063\/1.3607605"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq124"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05794.x"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijthermalsci.2005.11.009"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/ac010370l"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/ac071268c"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.860387"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2021.100343"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.790304"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/cb900263z"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00080"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1007\/bf00928361"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-032620-105429"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.18.12236"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.01.003"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1213"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709207104"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00765"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1039\/d1cc05367a"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-021-00366-3"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.05.015"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.049"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16117"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-005-0343-8"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9055"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3233\/jhd-200429"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6846"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.047"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017150108"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4382"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.038"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.028"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.7554\/elife.09347"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.07.012"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-017-9766-1"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c13653","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.2c13653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T08:13:56Z","timestamp":1683101636000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c13653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,16]]},"references-count":69,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2023,5,3]]}},"alternative-id":["10.1021\/jacs.2c13653"],"URL":"https:\/\/doi.org\/10.1021\/jacs.2c13653","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,16]]}}}