{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:18:37Z","timestamp":1790000317589,"version":"4.0.1"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100007703","name":"North Carolina State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2020-65207-30774"],"award-info":[{"award-number":["2020-65207-30774"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2023,6,7]]},"DOI":"10.1021\/jacs.3c03640","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T02:14:21Z","timestamp":1684808061000},"page":"12407-12422","source":"Crossref","is-referenced-by-count":42,"title":["Comparison of Aptamer Signaling Mechanisms Reveals Disparities in Sensor Response and Strategies to Eliminate False Signals"],"prefix":"10.1021","volume":"145","author":[{"given":"Obtin","family":"Alkhamis","sequence":"first","affiliation":[{"name":"Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Raleigh, North Carolina 27695, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Canoura","sequence":"additional","affiliation":[{"name":"Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Raleigh, North Carolina 27695, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Willis","sequence":"additional","affiliation":[{"name":"Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Raleigh, North Carolina 27695, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-3397","authenticated-orcid":true,"given":"Linlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Raleigh, North Carolina 27695, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Raleigh, North Carolina 27695, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7278-9811","authenticated-orcid":true,"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Raleigh, North Carolina 27695, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2200121"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/346818a0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-017-0076"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.199"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3141"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008663"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/cr030183i"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/ja0038171"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/ja028962o"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/ja2084256"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ja070180d"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200502589"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200500989"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b03763"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04975"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/ac100709s"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2011.07.069"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC01833E"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b03625"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gni063"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ac071059s"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ac5037236"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/ja069291n"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c01095"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201700748"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c10928"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/ja072269p"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.09.017"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/bi00002a033"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1126\/science.7510417"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa849"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09559"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC00086H"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c01773"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.2460\/javma.250.2.182"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1210"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09522"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)44753-3"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)93898-6"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)51774-9"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky305"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b00630"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200903998"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3197-2_8"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp026"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.12.035"},{"key":"ref47\/cit47","unstructured":"Bailey, T. L.; Elkan, C.In  Fitting a Mixture Model by Expectation Maximization to Discover Motifs in Biopolymers, Proceedings of the International Conference on Intelligent Systems for Molecular Biology, 1994; pp 28\u201336."},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12981"},{"key":"ref49\/cit49","first-page":"433","volume":"47","author":"Black W. D.","year":"1983","journal-title":"Can. J. Comp. Med."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1994.tb00514.x"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)33710-X"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.2754\/avb200978010155"},{"key":"ref53\/cit53","unstructured":"The European Agency for the Evaluation of Medicinal Products\nVeterinary Medicines Evaluation Unit. Chlorpromazine Summary Report, 1996. https:\/\/www.ema.europa.eu\/en\/documents\/mrl-report\/chlorpromazine-summary-report-committee-veterinary-medicinal-products_en.pdf (accessed January 02, 2023)."},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.3.854-862.2003"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.4.676"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2318(06)60006-1"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b01633"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.8b05795"},{"key":"ref59\/cit59","first-page":"53","volume":"7","author":"Kantesaria P.","year":"1975","journal-title":"Physiol. Chem. Phys."},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1981.tb08968.x"},{"key":"ref61\/cit61","first-page":"263","volume":"8","author":"Masotti L.","year":"1985","journal-title":"Microbiologica"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2016.03.009"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c03640","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c03640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T09:26:34Z","timestamp":1686129994000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.3c03640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":62,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2023,6,7]]}},"alternative-id":["10.1021\/jacs.3c03640"],"URL":"https:\/\/doi.org\/10.1021\/jacs.3c03640","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,22]]}}}